MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 16578 in total

Value Type  : Measured
Filtered  : 1

Rank	description	Network Comparison Type	Interaction Map	red	green	network_comparison
1	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Subtracted	Low confidence	40899	32028.5	8870.5
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Divided		2399.5	543.5	4.4149
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Subtracted	High confidence	41482.5	33356.5	8126
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Divided		450.5	2394.5	5.31521
2	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Subtracted	Low confidence	21185	28492	7307
	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Divided		2399.5	543.5	4.4149
	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Subtracted	High confidence	41482.5	33356.5	8126
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Divided		450.5	2394.5	5.31521
3	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]		Low confidence	2399.5	543.5	4.4149
	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Subtracted	High confidence	41482.5	33356.5	8126
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided		2597.5	698.5	3.71868
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Subtracted	Low confidence	21185	28492	7307
4	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]			36474.3	43509.4	7035.1
	cytohesin 4. [swissprot;acc:q9uia0]		High confidence	41482.5	33356.5	8126
	hbs1-like. [refseq;acc:nm_006620]	Divided		2597.5	698.5	3.71868
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]		Low confidence	2399.5	543.5	4.4149
5	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Subtracted	High confidence	41482.5	33356.5	8126
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Divided		1153.5	339.5	3.39764
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]		Low confidence	736.5	2113.5	2.86965
	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	Subtracted		36469.3	43503.3	7034
6	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Divided	High confidence	1153.5	339.5	3.39764
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Subtracted	Low confidence	36360.3	43368.8	7008.5
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Divided		736.5	2113.5	2.86965
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Subtracted	High confidence	44490.5	36927.5	7563
7	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]			21185	28492	7307
	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	Divided	Low confidence	736.5	2113.5	2.86965
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]		High confidence	1153.5	339.5	3.39764
	vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682]	Subtracted	Low confidence	36360.3	43368.8	7008.5
8	db83 protein. [swissprot;acc:p57088]	Divided	High confidence	1153.5	339.5	3.39764
	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Subtracted	Low confidence	33111.4	39358.1	6246.7
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]		High confidence	21185	28492	7307
	phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326]	Divided	Low confidence	3278	5058.5	1.54317
9	n33 protein. [swissprot;acc:q13454]
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Subtracted	High confidence	21185	28492	7307
	sperm associated antigen 7. [refseq;acc:nm_004890]		Low confidence	23318	19280.8	4037.2
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Divided	High confidence	398.5	1281.5	3.21581
10	implantation-associated protein. [refseq;acc:nm_032121]		Low confidence	3278	5058.5	1.54317
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	Subtracted	High confidence	21185	28492	7307
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]		Low confidence	19498.1	17265.4	2232.7
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Divided	High confidence	398.5	1281.5	3.21581
11	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Subtracted		21185	28492	7307
	retinoblastoma-associated factor 600. [refseq;acc:nm_020765]		Low confidence	7256.71	9368.87	2112.16
	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	Divided		1917.64	2950.5	1.53861
12	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]		High confidence	398.5	1281.5	3.21581
	gbp protein isoform a. [refseq;acc:nm_017870]		Low confidence	1921.96	2954.24	1.5371
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	Subtracted		15464.1	17572.7	2108.6
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]		High confidence	34190.9	40795.8	6604.9
13	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Divided		398.5	1281.5	3.21581
	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	Subtracted	Low confidence	15464.1	17572.7	2108.6

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.