MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1701 to 1750 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
851	n-myc proto-oncogene protein. [swissprot;acc:p04198]	Subtracted	227.601	219.008	8.593
	trs85 homolog. [swissprot;acc:q9y2l5]	Divided	107.842	112.329	1.04161
852	ga binding protein alpha chain (gabp-alpha subunit) (transcription factor e4tf1-60) (nuclear respiratory factor-2 subunit alpha). [swissprot;acc:q06546]	Subtracted	227.596	219.017	8.579
	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]	Divided	193.114	185.412	1.04154
853	ga binding protein beta-2 chain (gabp-beta-2 subunit) (transcription factor e4tf1-47) (gapbp-2) (nuclear respiratory factor-2 subunit gamma). [swissprot;acc:q06545]	Subtracted	227.596	219.017	8.579
	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	Divided	108.289	112.772	1.0414
854	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]
	nadh-ubiquinone oxidoreductase 23 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-23kd) (ci-23kd) (tyky subunit). [swissprot;acc:o00217]	Subtracted	227.596	219.017	8.579
855	elongation of very long chain fatty acids protein 1 (cgi-88). [swissprot;acc:q9bw60]			219.018	8.578
	tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452]	Divided	178.514	171.42	1.04138
856	myc proto-oncogene protein (c-myc). [swissprot;acc:p01106]	Subtracted	227.585	219.037	8.548
	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	Divided	215.028	206.623	1.04068
857	midasin (midas-containing protein). [swissprot;acc:q9nu22]	Subtracted	237.218	228.698	8.52
	putatative 28 kda protein. [refseq;acc:nm_020143]	Divided	227.241	236.467	1.0406
858	signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9]	Subtracted	221.306	212.806	8.5
	syntaxin 12. [refseq;acc:nm_177424]	Divided	217.446	208.997	1.04043
859	60s ribosomal protein l39. [swissprot;acc:p02404]		234.025	224.958	1.04031
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Subtracted	50.7983	42.3003	8.498
860	60s ribosomal protein l18a. [swissprot;acc:q02543]	Divided	234.025	224.958	1.04031
	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	Subtracted	242.024	233.544	8.48
861	40s ribosomal protein s19. [swissprot;acc:p39019]	Divided	234.025	224.958	1.04031
	syntaxin 12. [refseq;acc:nm_177424]	Subtracted	217.446	208.997	8.449
862	60s ribosomal protein l31. [swissprot;acc:p12947]	Divided	234.025	224.958	1.04031
	pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618]	Subtracted	231.357	239.778	8.421
863	casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]	Divided	240.194	230.957	1.03999
	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	Subtracted	215.028	206.623	8.405
864	casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]	Divided	240.194	230.957	1.03999
	exocyst complex component sec8. [swissprot;acc:q96a65]	Subtracted	217.762	209.449	8.313
865	transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290]	Divided	211.961	203.814	1.03997
	zinc finger protein 174 (aw-1). [swissprot;acc:q15697]	Subtracted	269.963	278.239	8.276
866	signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9]	Divided	221.306	212.806	1.03994
	zinc finger imprinted 2. [swissprot;acc:q9nzv7]	Subtracted	269.96	278.232	8.272
867	40s ribosomal protein s3a. [swissprot;acc:p49241]	Divided	225.689	234.674	1.03981
	zinc finger protein 18 (zinc finger protein kox11) (fragment). [swissprot;acc:p17022]	Subtracted	269.956	278.223	8.267
868	diphosphomevalonate decarboxylase (ec 4.1.1.33) (mevalonate pyrophosphate decarboxylase) (mevalonate (diphospho)decarboxylase). [swissprot;acc:p53602]	Divided	233.298	242.571	1.03975
	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	Subtracted	269.956	278.223	8.267
869	exocyst complex component sec8. [swissprot;acc:q96a65]	Divided	217.762	209.449	1.03969
	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]	Subtracted	269.955	278.221	8.266
870	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	Divided	211.908	203.832	1.03962
	zinc finger protein 305. [swissprot;acc:o43309]	Subtracted	269.954	278.219	8.265
871	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	Divided	110.2	114.552	1.03949
	zinc finger protein 232. [swissprot;acc:q9uny5]	Subtracted	269.954	278.218	8.264
872	heterogeneous nuclear ribonucleoprotein k (hnrnp k) (dc-stretch binding protein) (csbp) (transformation upregulated nuclear protein) (tunp). [swissprot;acc:q07244]	Divided	224.413	233.272	1.03948
	zinc finger protein 99. [refseq;acc:nm_032164]	Subtracted	269.954	278.218	8.264
873	u4/u6 small nuclear ribonucleoprotein prp4 (u4/u6 snrnp 60 kda protein) (wd splicing factor prp4) (hprp4). [swissprot;acc:o43172]	Divided	224.413	233.272	1.03948
	zinc finger protein 213 (putative transcription factor cr53). [swissprot;acc:o14771]	Subtracted	269.954	278.217	8.263
874	5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619]	Divided	212.002	203.954	1.03946
	zinc finger protein 274 (zinc finger protein sp2114) (zinc finger protein hfb101) (zinc finger protein zfp2) (zf2). [swissprot;acc:q96gc6]	Subtracted	269.953	278.215	8.262
875	5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646]	Divided	212.002	203.954	1.03946
	junction plakoglobin (desmoplakin iii). [swissprot;acc:p14923]	Subtracted	223.906	215.653	8.253

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.