MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 6691 to 6740 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
sorbitol dehydrogenase (ec 1.1.1.14) (l-iditol 2-dehydrogenase). [swissprot;acc:q00796]	2296	SORD	Low confidence	199.811	196.134	1.01875
sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	798	SRI		202.524	197.308	1.02644
	943		High confidence	212.442	205.087	1.03586
sortilin precursor (glycoprotein 95) (gp95) (neurotensin receptor 3) (nt3) (100 kda nt receptor). [swissprot;acc:q99523]	918	SORT1	Low confidence	198.577	193.713	1.02511
sortilin-related receptor precursor (sorting protein-related receptor containing ldlr class a repeats) (sorla) (sorla-1) (low-density lipoprotein receptor relative with 11 ligand-binding repeats) (ldlr relative with 11 ligand-binding repeats) (lr11). [swissprot;acc:q92673]	3208	SORL1		197.377	194.268	1.016
sorting nexin 1. [swissprot;acc:q13596]	1150	SNX1	High confidence	209.868	215.522	1.02694
	3322		Low confidence	201.32	198.222	1.01563
sorting nexin 12. [swissprot;acc:q9umy4]	4050	SNX12		202.534	200.264	1.01134
sorting nexin 13 (rgs domain- and phox domain-containing protein) (rgs-px1). [swissprot;acc:q9y5w8]	243	SNX13	High confidence	227.357	254.15	1.11785
	1957		Low confidence	204.481	200.546	1.01962
sorting nexin 15. [swissprot;acc:q9nrs6]	2936	SNX15		200.53	197.18	1.01699
sorting nexin 16. [swissprot;acc:p57768]	721	SNX16		203.411	197.971	1.02748
	3108		High confidence	0.00001	0.00001	1
sorting nexin 17. [swissprot;acc:q15036]	638	SNX17		228.639	242.258	1.05957
	3176		Low confidence	202.594	199.371	1.01617
sorting nexin 27. [swissprot;acc:q96l92]	3076	SNX27		202.081	198.793	1.01654
sorting nexin 3 (sdp3 protein). [swissprot;acc:o60493]	4051	SNX3		202.534	200.264	1.01134
sorting nexin 5. [swissprot;acc:q9y5x3]	678	SNX5	High confidence	208.482	220.175	1.05609
	4605		Low confidence	201.252	199.828	1.00713
sorting nexin 6 (traf4-associated factor 2). [swissprot;acc:q9unh7]	778	SNX6	High confidence	209.191	219.332	1.04848
	4272		Low confidence	201.271	199.393	1.00942
sorting nexin 9 (sh3 and px domain-containing protein 1) (sdp1 protein). [swissprot;acc:q9y5x1]	491	SNX9		209.136	202.478	1.03288
	2335		High confidence	229.258	230.294	1.00452
source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	254	STT3B		200.691	179.88	1.11569
	325		Low confidence	199.905	192.123	1.04051
sparc precursor (secreted protein acidic and rich in cysteine) (osteonectin) (on) (basement membrane protein bm-40). [swissprot;acc:p09486]	3062	SPARC	High confidence	0.00001	0.00001	1
	4866		Low confidence	196.51	197.068	1.00284
sparc-like protein 1 precursor (high endothelial venule protein) (hevin) (mast 9). [swissprot;acc:q14515]	2899	SPARCL1	High confidence	0.00001	0.00001	1
	4864		Low confidence	196.51	197.068	1.00284
spartin; trans-activated by hepatitis c virus core protein 1. [refseq;acc:nm_015087]	348	SPG20		210.796	202.935	1.03874
	2987		High confidence	0.00001	0.00001	1
spastin. [swissprot;acc:q9ubp0]	1589	SPAST	Low confidence	201.306	197.159	1.02103
speckle-type poz protein. [swissprot;acc:o43791]	1399	SPOP		201.397	197.08	1.0219
	3031		High confidence	0.00001	0.00001	1
spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813]	937	no value	Low confidence	194.236	189.504	1.02497
	3038		High confidence	0.00001	0.00001	1
spectrin beta chain, brain 1 (spectrin, non-erythroid beta chain 1) (beta-ii spectrin) (fodrin beta chain). [swissprot;acc:q01082]	1773	SPTBN1		223.032	225.739	1.01214
	3510		Low confidence	197.276	194.375	1.01492
spectrin beta chain, brain 2 (spectrin, non-erythroid beta chain 2) (beta-iii spectrin). [swissprot;acc:o15020]	1772	SPTBN2	High confidence	223.032	225.739	1.01214
	3509		Low confidence	197.276	194.375	1.01492
spectrin beta chain, brain 4 (spectrin, non-erythroid beta chain 4) (beta-v spectrin) (bspecv). [swissprot;acc:q9nrc6]	2143	SPTBN5	High confidence	206.442	207.862	1.00688
	2499		Low confidence	198.748	195.198	1.01819
spectrin sh3 domain binding protein 1; eps8 binding protein; interactor protein ablbp4; abl-interactor protein 1 long; nap1 binding protein. [refseq;acc:nm_005470]	785	ABI1		202.469	197.233	1.02655
	1846		High confidence	217.066	214.698	1.01103
sperm associated antigen 7. [refseq;acc:nm_004890]	365	SPAG7	Low confidence	117.525	121.959	1.03773
sperm tail protein shippo1; h-shippo 1. [refseq;acc:nm_053280]	2797	ODF3	High confidence	0.00001	0.00001	1
	3564		Low confidence	201.273	198.378	1.01459
spermatogenesis associated 6. [refseq;acc:nm_019073]	51	SPATA6	High confidence	133	105	1.26667
	3266		Low confidence	202.431	199.293	1.01575
spermatogenesis associated factor spaf. [refseq;acc:nm_145207]	705	SPATA5		205.124	199.576	1.0278

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.