MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 6664 to 6713 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : Low confidence
Filtered  : 1

Rank	Hugo	description	red	green	network_comparison
3436	PGM5P1	phosphoglucomutase-like protein 5 (phosphoglucomutase-related protein) (pgm-rp) (aciculin). [swissprot;acc:q15124]	201.213	198.202	1.01519
3437	MTO1	mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2]	199.422	196.439
3438	INADL	inad-like protein isoform 3; pdz domain protein (drosophila inad-like); protein associated to tight junctions; pals1-associated tight junction protein; inactivation no after-potential d-like protein. [refseq;acc:nm_005799]	196.976	194.028
3439	CPXM2	potential carboxypeptidase-like protein x2 precursor. [swissprot;acc:q8n436]	201.282	198.271
3440	MED28	endothelial-derived gene 1. [refseq;acc:nm_025205]	198.635	195.663
3441	CPZ	cpz gene product. [refseq;acc:nm_003652]	201.285	198.273
3442	MPDZ	multiple pdz domain protein. [refseq;acc:nm_003829]	196.978	194.03
3443	CDC23	cell division cycle protein 23; anaphase-promoting complex subunit 8. [refseq;acc:nm_004661]	201.288	198.276
3444	GLG1	golgi apparatus protein 1 precursor (golgi sialoglycoprotein mg-160) (e-selectin ligand 1) (esl-1) (cysteine-rich fibroblast growth factor receptor) (cfr-1). [swissprot;acc:q92896]
3445	CPXM1	potential carboxypeptidase x precursor (ec 3.4.17.-) (metallocarboxypeptidase cpx-1). [swissprot;acc:q96sm3]	201.282	198.271
3446	WBP11	ww domain binding protein 11; npw38-binding protein npwbp; sh3 domain-binding protein snp70. [refseq;acc:nm_016312]	196.979	194.031
3447	ELAC2	elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127]
3448	KLHDC3	testis intracellular mediator protein. [refseq;acc:nm_057161]	203.333	200.293	1.01518
3449	EZH1	enhancer of zeste homolog 1 (enx-2). [swissprot;acc:q92800]
3450	EZH2	enhancer of zeste homolog 2 (enx-1). [swissprot;acc:q15910]
3451	LSM8	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	204.036	200.989	1.01516
3452	PPP2R1A	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	198.794	195.825
3453	HK2	hexokinase, type ii (ec 2.7.1.1) (hk ii) (muscle form hexokinase). [swissprot;acc:p52789]	200.319	197.33	1.01515
3454	no value	presenilin enhancer 2; hematopoietic stem/progenitor cells protein mds033. [refseq;acc:nm_172341]	202.622	199.599
3455	SGTA	small glutamine-rich tetratricopeptide repeat-containing protein (vpu-binding protein) (ubp). [swissprot;acc:o43765]	197.533	194.585
3456	ATPAF2	atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691]	202.709	199.686	1.01514
3457	TPD52L2	tumor protein d54 (hd54) (d52-like 2). [swissprot;acc:o43399]	201.597	198.59
3458	HK1	hexokinase, type i (ec 2.7.1.1) (hk i) (brain form hexokinase). [swissprot;acc:p19367]	200.307	197.322	1.01513
3459	PGM1	phosphoglucomutase (ec 5.4.2.2) (glucose phosphomutase) (pgm). [swissprot;acc:p36871]	201.212	198.213
3460	ZBTB6	zinc finger protein with interaction domain. [refseq;acc:nm_006626]	200.298	197.317	1.01511
3461	ZBTB26	zinc finger protein bioref. [swissprot;acc:q9hck0]	200.299	197.318
3462	HK3	hexokinase type iii (ec 2.7.1.1) (hk iii). [swissprot;acc:p52790]	200.296	197.315
3463	ATP5L	atp synthase g chain, mitochondrial (ec 3.6.3.14) (atpase subunit g). [swissprot;acc:o75964]	202.723	199.708	1.0151
3464	no value	proteasome subunit beta type 9 precursor (ec 3.4.25.1) (proteasome chain 7) (macropain chain 7) (multicatalytic endopeptidase complex chain 7) (ring12 protein) (low molecular mass protein 2). [swissprot;acc:p28065]	199.995	197.02
3465	GCK	hexokinase d (ec 2.7.1.1) (hexokinase type iv) (hk iv) (hk4) (glucokinase). [swissprot;acc:p35557]	200.291	197.312
3466	IDH3B	isocitrate dehydrogenase [nad] subunit beta, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). [swissprot;acc:o43837]	200.419	197.437
3467	SNAPAP	snare associated protein snapin. [refseq;acc:nm_012437]	201.389	198.396	1.01509
3468	NCL	nucleolin (protein c23). [swissprot;acc:p19338]	188.235	185.438	1.01508
3469	ZBTB43	zinc finger protein 297b (znf-x). [swissprot;acc:o43298]	200.3	197.326	1.01507
3470	ATP1B3	sodium/potassium-transporting atpase beta-3 chain (sodium/potassium- dependent atpase beta-3 subunit) (atpb-3). [swissprot;acc:p54709]	197.125	194.199
3471	ATP1B2	sodium/potassium-transporting atpase beta-2 chain (sodium/potassium- dependent atpase beta-2 subunit). [swissprot;acc:p14415]	197.112	194.188	1.01506
3472	LMBR1	limb region 1 protein; limb region 1. [refseq;acc:nm_022458]	204.082	201.054
3473	ATP1B4	x/potassium-transporting atpase beta-m chain (x,k-atpase beta-m subunit). [swissprot;acc:q9un42]	197.122	194.197
3474	TDP1	tyrosyl-dna phosphodiesterase 1; tyrosyl-dna phosphodiesterase. [refseq;acc:nm_018319]	202.946	199.936	1.01505
3475	LMBR1L	lipocalin-interacting membrane receptor. [refseq;acc:nm_018113]	204.091	201.067	1.01504
3476	PHF7	phd finger protein 7 isoform 1. [refseq;acc:nm_016483]	201.206	198.224
3477	VPS28	vps28 protein homolog. [swissprot;acc:q9uk41]	202.414	205.457	1.01503
3478	HSP90AA2	heat shock protein hsp 90-alpha (hsp 86). [swissprot;acc:p07900]	201.611	198.628	1.01502
3479	BARD1	brca1-associated ring domain protein 1 (bard-1). [swissprot;acc:q99728]	199.172	196.226	1.01501
3480	ALDH7A1	aldehyde dehydrogenase family 7 member a1 (ec 1.2.1.3) (antiquitin 1). [swissprot;acc:p49419]	201.442	198.465	1.015
3481	GSTP1	glutathione s-transferase p (ec 2.5.1.18) (gst class-pi) (gstp1-1). [swissprot;acc:p09211]	202.657	199.662
3482	C11orf54	ptd012 protein. [refseq;acc:nm_014039]	202.475	199.484	1.01499
3483	MAB21L2	mab-21-like protein 2; mab-21-like 2. [refseq;acc:nm_006439]
3484	MAB21L1	mab-21-like protein 1; mab-21-like 1. [refseq;acc:nm_005584]
3485	TPBG	5t4 oncofetal trophoblast glycoprotein; 5t4-antigen. [refseq;acc:nm_006670]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.