MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Network Comparison Type	Rank	Gene	Hugo	description	Value Type	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 658 to 707 of 2060 in total

Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Filtered  : 1
network_comparison  : 0
red  : 0
green  : 0

Rank	Hugo	description	Value Type
2920	GLRA3	glycine receptor alpha-3 chain precursor. [swissprot;acc:o75311]	Ranked
			Squared
			Rooted
2921	EAF2	ell-associated factor 2; uncharacterized bone marrow protein bm040; testosterone regulated apoptosis inducer and tumor suppressor. [refseq;acc:nm_018456]	Measured
			Ranked
			Squared
			Rooted
2922	ALDH1L1	10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	Measured
			Ranked
			Squared
			Rooted
2923	TMEM4	transmembrane protein 4. [refseq;acc:nm_014255]	Measured
			Ranked
			Squared
			Rooted
2924	RQCD1	rcd1 required for cell differentiation1 homolog; protein involved in sexual development; rcd1 (required for cell differentiation, s.pombe) homolog 1. [refseq;acc:nm_005444]	Measured
			Ranked
			Squared
			Rooted
2925	RALB	ras-related protein ral-b. [swissprot;acc:p11234]	Measured
			Ranked
			Squared
			Rooted
2926	DUSP11	dual specificity protein phosphatase 11 (ec 3.1.3.48) (rna/rnp complex-intereracting phosphatase) (phosphatase that interacts with rna/rnp complex 1). [swissprot;acc:o75319]	Measured
			Ranked
			Squared
			Rooted
2927	CIAO1	wd-repeat containing protein ciao 1. [swissprot;acc:o76071]	Measured
			Ranked
			Squared
			Rooted
2928	no value	calmodulin. [swissprot;acc:p02593]	Measured
			Ranked
			Squared
			Rooted
2929	LYST	lysosomal trafficking regulator (beige homolog). [swissprot;acc:q99698]	Measured
			Ranked
			Squared
			Rooted
2930	ILF2	interleukin enhancer binding factor 2; nuclear factor of activated t-cells, 45-kda. [refseq;acc:nm_004515]	Measured
			Ranked
			Squared
			Rooted
2931	TPM3	tropomyosin alpha 3 chain (tropomyosin 3) (tropomyosin gamma). [swissprot;acc:p06753]	Measured
			Ranked
			Squared
			Rooted
2932	POGZ	pogo transposable element with znf domain isoform 1. [refseq;acc:nm_015100]	Measured
			Ranked
			Squared

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.