MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 658 to 707 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
aminoadipate-semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase. [refseq;acc:nm_005763]	3212	AASS	Low confidence	202.212	199.028	1.016
aminomethyltransferase, mitochondrial precursor (ec 2.1.2.10) (glycine cleavage system t protein) (gcvt). [swissprot;acc:p48728]	2544	AMT	High confidence	212.67	212.262	1.00192
	2903		Low confidence	196.135	192.845	1.01706
ammecr1 protein. [refseq;acc:nm_015365]	1577	AMMECR1	High confidence	222.585	218.982	1.01645
	2922		Low confidence	193.976	190.73	1.01702
amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	52	AMPD2	High confidence	133	105	1.26667
	799		Low confidence	201.294	196.11	1.02643
amphiphysin. [swissprot;acc:p49418]	2389	AMPH		202.089	198.416	1.01851
amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	79	APBA1		229.144	208.803	1.09742
	139		High confidence	271.752	225.68	1.20415
amyloid beta a4 protein precursor (app) (abpp) (alzheimer's disease amyloid protein) (cerebral vascular amyloid peptide) (cvap) (protease nexin-ii) (pn-ii) (appi) (prea4) [contains: soluble app-alpha (s-app- alpha); soluble app-beta (s-app-beta); c99; beta-amyloid protein 42 (beta-app42); beta-amyloid protein 40 (beta-app40); c83; p3(42); p3(40); gamma-ctf(59) (gamma-secretase c-terminal fragment 59) (amyloid intracellular domain 59) (aid(59)); gamma-ctf(57) (gamma- secretase c-terminal fragment 57) (amyloid intracellular domain 57) (aid(57)); gamma-ctf(50) (gamma-secretase c-terminal fragment 50) (amyloid intracellular domain 50) (aid(50)); c31]. [swissprot;acc:p05067]	508	APP	Low confidence	205.157	198.715	1.03242
amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905]	810	APPBP1		196.326	191.3	1.02627
	2490		High confidence	194.527	195.08	1.00284
amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail)-binding protein 2; protein interacting with app tail 1. [refseq;acc:nm_006380]	3191	APPBP2		0.00001	0.00001	1
	3371		Low confidence	200.658	197.607	1.01544
amyloid-like protein 1 precursor (aplp) (aplp-1) [contains: c30]. [swissprot;acc:p51693]	512	APLP1		205.157	198.715	1.03242
amyloid-like protein 2 precursor (amyloid protein homolog) (apph) (cdei-box binding protein) (cdebp). [swissprot;acc:q06481]	518	APLP2		205.156		1.03241
anaphase promoting complex subunit 11 (hepatocellular carcinoma associated ring finger protein) (hspc214). [swissprot;acc:q9nyg5]	2636	ANAPC11	High confidence	195.635	195.384	1.00128
	4090		Low confidence	202.978	200.781	1.01094
anaphase-promoting complex 1 (meiotic checkpoint regulator). [refseq;acc:nm_022662]	4764	ANAPC1		200.161	201.146	1.00492
anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]	207	ANAPC10		213.495	203.244	1.05044
	2663		High confidence	204.768	204.549	1.00107
anaphase-promoting complex subunit 2; anaphase-promoting complex 2. [refseq;acc:nm_013366]	2679	ANAPC2		190.142	189.959	1.00096
	4577		Low confidence	202.548	204.086	1.00759
anchor attachment protein 1; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (gaa1p, yeast) homolog. [refseq;acc:nm_003801]	1649	no value		200.535	196.468	1.0207
androgen receptor coactivator ara55; hic-5. [refseq;acc:nm_015927]	2926	TGFB1I1		204.222	200.808	1.017
androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	240	AIG1	High confidence	227.357	254.15	1.11785
	1254		Low confidence	204.026	199.515	1.02261
androgen-regulated short-chain dehydrogenase/reductase 1; prostate short-chain dehydrogenase reductase 1; cgi-82 protein; hcv core-binding protein; likely ortholog of mouse cell line mc/9.il4 derived transcript 1; likely ortholog of mouse prostate short-chain steroid dehydrogenase/reductase 1; retinol dehydrogenase 11. [refseq;acc:nm_016026]	3132	RDH11		200.082	196.855	1.01639
angiomotin like 2; leman coiled-coil protein; angiomotin-like protein 2. [refseq;acc:nm_016201]	2586	AMOTL2	High confidence	213.422	213.75	1.00154
	3283		Low confidence	202.385	199.258	1.01569
angiomotin. [refseq;acc:nm_133265]	2585	AMOT	High confidence	213.422	213.75	1.00154
	3282		Low confidence	202.385	199.258	1.01569
angiotensin-converting enzyme, somatic isoform precursor (ec 3.4.15.1) (ace) (dipeptidyl carboxypeptidase i) (kininase ii) (cd143 antigen). [swissprot;acc:p12821]	4093	ACE		202.132	199.957	1.01088
anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	143	ANLN	High confidence	59	49	1.20408
	986		Low confidence	192.111	187.496	1.02461
anion exchange protein 2 (non-erythroid band 3-like protein) (bnd3l). [swissprot;acc:p04920]	3888	SLC4A2		204.559	201.988	1.01273
ankyrin 2 (brain ankyrin) (ankyrin b) (ankyrin, nonerythroid). [swissprot;acc:q01484]	2519	ANK2	High confidence	215.835	216.341	1.00234
	4158		Low confidence	202.624	200.519	1.0105
ankyrin 3 (ank-3) (ankyrin g). [swissprot;acc:q12955]	2518	ANK3	High confidence	215.835	216.341	1.00234
	4157		Low confidence	202.624	200.519	1.0105
ankyrin repeat and btb (poz) domain containing 1 isoform 1; elongation factor 1a binding protein. [refseq;acc:nm_032548]	595	ABTB1		205.485	199.453	1.03024
ankyrin repeat domain protein 7 (testis-specific protein tsa806). [swissprot;acc:q92527]	260	ANKRD7		216.855	207.34	1.04589
ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	805	ANKRA2	High confidence	212.386	221.785	1.04425
	4203		Low confidence	203.592	201.541	1.01018
annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	1088	ANXA11	High confidence	219.673	213.378	1.0295
	1400		Low confidence	203.717	199.354	1.02189
annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	1094	ANXA7	High confidence	219.655	213.385	1.02938
	1394		Low confidence	203.731	199.363	1.02191
antithrombin-iii precursor (atiii) (pro0309). [swissprot;acc:p01008]	2418	SERPINC1	High confidence	218.2	218.984	1.00359

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.