MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 651 to 700 of 29840 in total

Interaction Map  : High confidence

Rank	description	Value Type	Network Comparison Type	Filtered	red	green	network_comparison
41	nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [swissprot;acc:q16718]	Measured	Divided	0	266	645	2.42481
	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	Ranked		1	322	253	1.27273
	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Rooted	Subtracted		60.8365	77.7233	16.8868
	spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813]			0	42.8135	51.3517	8.5382
	suppressor of actin 1. [refseq;acc:nm_014016]		Divided		3.30572	5.87091	1.77599
	trophinin. [swissprot;acc:q12816]	Measured	Subtracted	1	23693.7	18263	5430.7
42	acyl-coa dehydrogenase, short/branched chain specific, mitochondrial precursor (ec 1.3.99.-) (sbcad) (2-methyl branched chain acyl-coa dehydrogenase) (2-mebcad) (2-methylbutyryl-coenzyme a dehydrogenase) (2-methylbutyryl-coa dehydrogenase). [swissprot;acc:p45954]	Rooted	Divided	0	5.11118	9.0312	1.76695
	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	Ranked			8158	5530.5	1.47509
	cleavage and polyadenylation specificity factor, 73 kda subunit (cpsf 73 kda subunit). [swissprot;acc:q9ukf6]	Squared	Subtracted	1	211446	137422	74024
	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	Ranked		0	9429.18	5208.84	4220.34
	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	Measured		1	21785.2	16426.1	5359.1
	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]		Divided		1857.32	958.237	1.93827
		Rooted			40.225	24.7051	1.62821
	jun dimerization protein. [refseq;acc:nm_130469]		Subtracted		60.8365	77.7233	16.8868
	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	Squared	Divided		144911	81154.7	1.78561
	nanos (fragment). [sptrembl;acc:q8wy41]			0	33.64	5.39669	6.23345
	presenilin enhancer 2; hematopoietic stem/progenitor cells protein mds033. [refseq;acc:nm_172341]	Measured			205.439	86.9525	2.36266
	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Ranked		1	204.641	160.957	1.2714
	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	Rooted	Subtracted	0	90.4079	98.9265	8.5186
	spectrin beta chain, brain 4 (spectrin, non-erythroid beta chain 4) (beta-v spectrin) (bspecv). [swissprot;acc:q9nrc6]	Squared			36765.6	31220.1	5545.5
	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	Ranked		1	332.874	267.246	65.628
	trinucleotide repeat containing 15. [refseq;acc:nm_015575]	Measured		0	18889	19496	607
43	40s ribosomal protein s26. [swissprot;acc:p02383]	Rooted	Divided		9.92134	5.66499	1.75134
	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	Measured	Subtracted	1	21785.2	16426.1	5359.1
	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Squared	Divided		144876	81136.5	1.78558
	dok-like protein. [refseq;acc:nm_024872]	Ranked	Subtracted	0	17571	21783	4212
	elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897]	Measured	Divided		263.66	587.988	2.2301
	fos-related antigen 2. [swissprot;acc:p15408]	Rooted	Subtracted	1	60.8675	77.7168	16.8493
	glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712]	Ranked	Divided	0	12143.8	8356.02	1.4533
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	Rooted		1	40.6302	25.4452	1.59677
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	Measured			1881.02	1027.36	1.83093
	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	Squared	Subtracted	0	84951.4	90481	5529.6
	jun dimerization protein. [refseq;acc:nm_130469]	Ranked	Divided	1	204.641	160.957	1.2714
	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]		Subtracted		332.874	267.246	65.628
	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Squared			110342	184298	73956
	nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [swissprot;acc:q16718]		Divided	0	16.747	98.4675	5.87971
	sh3-containing grb2-like protein 1 (sh3 domain protein 2b) (extra eleven-nineteen leukemia fusion gene) (een) (een fusion partner of mll). [swissprot;acc:q99961]	Measured	Subtracted		4089.65	4696.36	606.71
	zinc finger protein 277. [swissprot;acc:q9nrm2]	Rooted			90.4079	98.9265	8.5186
44	acyl-coa dehydrogenase, short/branched chain specific, mitochondrial precursor (ec 1.3.99.-) (sbcad) (2-methyl branched chain acyl-coa dehydrogenase) (2-mebcad) (2-methylbutyryl-coenzyme a dehydrogenase) (2-methylbutyryl-coa dehydrogenase). [swissprot;acc:p45954]	Measured	Divided		45.4292	98.5074	2.16837
	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]		Subtracted	1	28136.5	33457.6	5321.1
	fos-related antigen 2. [swissprot;acc:p15408]	Ranked	Divided		204.641	161.046	1.2707
	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Squared			139741	78454.6	1.78117
	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	Rooted		0	11.9583	6.85565	1.7443
	glutamate dehydrogenase 2, mitochondrial precursor (ec 1.4.1.3) (gdh). [swissprot;acc:p49448]	Ranked	Subtracted		15863.6	11662.3	4201.3
	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	Rooted	Divided	1	40.5691	25.4263	1.59556
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	Measured			1931.34	1057.39	1.82652
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	Ranked	Subtracted		332.874	267.246	65.628
	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	Squared			110342	184298	73956
	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Rooted			60.8692	77.7165	16.8473
	regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754]			0	33.5215	25.0836	8.4379

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.