MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Network Comparison Type	Gene	Value Type	Hugo	Interaction Map	red	Filtered	green	network_comparison

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Showing element 644 to 693 of 66312 in total

Filtered  : 1

description	Rank	Network Comparison Type	Value Type	Hugo	Interaction Map	red	green	network_comparison
26s proteasome non-atpase regulatory subunit 7 (26s proteasome regulatory subunit s12) (proteasome subunit p40) (mov34 protein homolog). [swissprot;acc:p51665]	2952	Divided	Rooted	PSMD7	Low confidence	72.6295	74.9748	1.03229
	3198		Ranked			200.29	197.129	1.01604
	3219	Subtracted						3.161
	3462		Squared			46162.3	44747.4	1414.9
	3621	Divided						1.03162
26s proteasome non-atpase regulatory subunit 8 (26s proteasome regulatory subunit s14) (p31). [swissprot;acc:p48556]	865	Subtracted	Measured	PSMD8		8126.23	8445.39	319.16
	917	Divided						1.03928
	1131	Subtracted	Rooted			72.7208	75.489	2.7682
	1168	Divided						1.03807
	1344	Subtracted	Squared		High confidence	27060.6	29916.8	2856.2
	1532		Measured			5916.05	6350.53	434.48
	1536	Divided						1.07344
	1691		Squared			27060.6	29916.8	1.10555
	1798		Ranked		Low confidence	200.037	196.088	1.02014
	1813	Subtracted						3.949
	1861	Divided	Rooted		High confidence	62.7784	64.64	1.02965
	1882	Subtracted						1.8616
	2519		Ranked			215.835	216.341	0.506
	2525	Divided						1.00234
	4414	Subtracted	Squared		Low confidence	46044.6	45065.1	979.5
	4452	Divided						1.02174
26s proteasome non-atpase regulatory subunit 9 (26s proteasome regulatory subunit p27). [swissprot;acc:o00233]	1232	Subtracted		PSMD9	High confidence	27762.4	30763.9	3001.5
	1340		Measured		Low confidence	8155.72	8435.4	279.68
	1454	Divided						1.03429
	1460	Subtracted			High confidence	5996.14	6439.46	443.32
	1517	Divided						1.07393
	1628		Squared			27762.4	30763.9	1.10811
	1688	Subtracted	Rooted		Low confidence	72.7463	75.3342	2.5879
	1799	Divided						1.03557
	1813	Subtracted			High confidence	63.0811	64.9964	1.9153
	1831	Divided						1.03036
	2077		Ranked		Low confidence	200.371	196.58	1.01928
	2100	Subtracted						3.791
	2620	Divided			High confidence	215.615	215.91	1.00137
	2627	Subtracted						0.295
	3915		Squared		Low confidence	46483.1	45240.2	1242.9
	4069	Divided						1.02747
26s proteasome-associated pad1 homolog. [refseq;acc:nm_005805]	1293	Subtracted		PSMD14	High confidence	26174.3	29098.4	2924.1
	1562	Divided						1.11172
	1643		Measured			5782.92	6186.39	1.06977
	1680	Subtracted						403.47
	1845				Low confidence	8106.21	8367.09	260.88
	2004	Divided						1.03218
	2103		Rooted		High confidence	61.9958	63.5389	1.02489
	2112	Subtracted						1.5431
	2127		Ranked			217.871	219.366	1.495
	2150	Divided						1.00686
	2440	Subtracted	Rooted		Low confidence	72.5526	74.9905	2.4379
	2507	Divided						1.0336
	2962	Subtracted	Ranked			200.589	197.26	3.329

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.