MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 6408 to 6456 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
zinc finger protein 289, id1 regulated; likely ortholog of mouse zfp289. [refseq;acc:nm_032389]	2126	ZNF289	Divided	221.248	222.788	1.00696
zinc finger protein 291. [swissprot;acc:q9by12]	261	SCAPER	Subtracted	242.14	265.696	23.556
	350		Divided			1.09728
zinc finger protein 305. [swissprot;acc:o43309]	870	ZSCAN12	Subtracted	269.954	278.219	8.265
	1065		Divided			1.03062
zinc finger protein 40 (human immunodeficiency virus type i enhancer- binding protein 1) (hiv-ep1) (major histocompatibility complex binding protein 1) (mbp-1) (positive regulatory domain ii binding factor 1) (prdii-bf1). [swissprot;acc:p15822]	1487	HIVEP1		207.877	203.989	1.01906
	1499		Subtracted			3.888
zinc finger protein 444; endothelial zinc finger protein 2. [refseq;acc:nm_018337]	877	ZNF444		269.896	278.093	8.197
	1080		Divided			1.03037
zinc finger protein 99. [refseq;acc:nm_032164]	872	ZNF394	Subtracted	269.954	278.218	8.264
	1070		Divided			1.03061
zinc finger protein gli1 (glioma-associated oncogene) (oncogene gli). [swissprot;acc:p08151]	2431	GLI1	Subtracted	235.812	235.088	0.724
	2466		Divided			1.00308
zinc finger protein gli2 (tax helper protein). [swissprot;acc:p10070]	2436	GLI2	Subtracted			0.724
	2471		Divided			1.00308
zinc finger protein gli3. [swissprot;acc:p10071]	2433	GLI3	Subtracted			0.724
	2468		Divided			1.00308
zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623]	1557	SNAI2		196.192	192.996	1.01656
	1631		Subtracted			3.196
zinc finger protein t86. [swissprot;acc:o00488]	505	ZNF593		246.805	231.796	15.009
	579		Divided			1.06475
zinc finger protein zic 1 (zinc finger protein of the cerebellum 1). [swissprot;acc:q15915]	1315	ZIC1	Subtracted	218.569	213.832	4.737
	1348		Divided			1.02215
zinc finger protein zic 2 (zinc finger protein of the cerebellum 2). [swissprot;acc:o95409]	1317	ZIC2	Subtracted	218.574	213.847	4.727
	1350		Divided			1.0221
zinc finger protein zic 3 (zinc finger protein of the cerebellum 3). [swissprot;acc:o60481]	1316	ZIC3	Subtracted	218.572	213.841	4.731
	1349		Divided			1.02212
zinc finger protein zic 4 (zinc finger protein of the cerebellum 4) (fragment). [swissprot;acc:q8n9l1]	1303	ZIC4	Subtracted	218.509	213.648	4.861
	1327		Divided			1.02275
zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782]	2190	ZFPL1		209.54	208.162	1.00662
	2202		Subtracted			1.378
zinc finger-like protein 9. [refseq;acc:nm_033414]	471	ZNF622		250.942	235.004	15.938
	532		Divided			1.06782
zinc ribbon domain containing, 1; transcription-associated zinc ribbon protein; rna polymerase i small specific subunit rpa12. [refseq;acc:nm_014596]	493	ZNRD1	Subtracted	236.751	252.038	15.287
	580		Divided			1.06457
zinc transporter 1 (znt-1). [swissprot;acc:q9y6m5]	2822	SLC30A1		0.00001	0.00001	1
			Subtracted	0	0	0
zinc transporter 3 (znt-3). [swissprot;acc:q99726]	3049	SLC30A3	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
zinc-finger protein zpr1 (zinc finger protein 259). [swissprot;acc:o75312]	2416	ZNF259		217.366	218.117	0.751
	2435		Divided			1.00346
zuotin related factor-1 (m-phase phosphoprotein 11). [swissprot;acc:q99543]	915	ZRF1	Subtracted	237.558	229.677	7.881
	960		Divided			1.03431
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (ec 2.7.1.115) (branched-chain alpha-ketoacid dehydrogenase kinase) (bckdhkin) (bckd-kinase). [swissprot;acc:o14874]	1518	BCKDK		213.259	209.524	1.01783
	1534		Subtracted			3.735
[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 1). [swissprot;acc:q15118]	1507	PDK1	Divided	213.274	209.5	1.01801
	1517		Subtracted			3.774
[pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 2). [swissprot;acc:q15119]	1508	PDK2	Divided			1.01801
	1518		Subtracted			3.774

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.