MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 64024 to 64073 of 66312 in total

Interaction Map  : Low confidence
Filtered  : 1

Rank	description	Hugo	Value Type	Network Comparison Type	red	green	network_comparison
4775	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	RGS17	Rooted	Subtracted	70.5022	71.647	1.1448
4776	40 kda peptidyl-prolyl cis-trans isomerase (ec 5.2.1.8) (ppiase) (rotamase) (cyclophilin-40) (cyp-40) (cyclophilin-related protein). [swissprot;acc:q08752]	PPID	Squared		47191.9	46667.2	524.7
	c-jun-amino-terminal kinase interacting protein 3 (jnk-interacting protein 3) (jip-3) (jnk map kinase scaffold protein 3) (mitogen- activated protein kinase 8-interacting protein 3). [swissprot;acc:q9upt6]	MAPK8IP3	Measured		7513.31	7609.98	96.67
	complement component c7 precursor. [swissprot;acc:p10643]	C7	Ranked		206.624	205.715	0.909
	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	GNAO1	Rooted		70.5022	71.647	1.1448
	ninein (gsk3b interacting protein). [refseq;acc:nm_016350]	NIN	Ranked	Divided	199.989	199.083	1.00455
	pregnancy-induced growth inhibitor okl38. [swissprot;acc:q9ujx0]	OSGIN1	Rooted		69.3271	70.4623	1.01637
	serine/threonine protein phosphatase pp1-gamma catalytic subunit (ec 3.1.3.16) (pp-1g). [swissprot;acc:p36873]	PPP1CC	Measured		8594.49	8700.08	1.01229
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	XAB1	Squared		47032.5	46477.1	1.01195
4777	60s ribosomal protein l13a (23 kda highly basic protein). [swissprot;acc:p40429]	RPL13A	Measured	Subtracted	7684.73	7780.81	96.08
	cg10958-like. [refseq;acc:nm_145038]	C2orf39	Squared	Divided	48580.3	49160.5	1.01194
	cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291]	CSRP1	Rooted		69.2624	70.3939	1.01634
	cytochrome b5 reductase 1 (b5r.1). [refseq;acc:nm_016243]	CYB5R1	Squared	Subtracted	45655.1	45134	521.1
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	GNB3	Ranked	Divided	200.171	201.076	1.00452
	hbs1-like. [refseq;acc:nm_006620]	HBS1L	Measured		7114.89	7029.07	1.01221
	lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461]	CSRP3	Rooted	Subtracted	69.2825	70.4241	1.1416
	ninein (gsk3b interacting protein). [refseq;acc:nm_016350]	NIN	Ranked		199.989	199.083	0.906
4778	contactin 2 precursor (axonin-1) (axonal glycoprotein tag-1) (transient axonal glycoprotein 1) (tax-1). [swissprot;acc:q02246]	CNTN2		Divided	201.633	200.734	1.00448
	deltex 2. [refseq;acc:nm_020892]	DTX2	Measured		7790.67	7885.3	1.01215
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	GNB3	Ranked	Subtracted	200.171	201.076	0.905
	nadh-cytochrome b5 reductase (ec 1.6.2.2) (b5r). [swissprot;acc:p00387]	CYB5R3	Squared		45655.1	45134	521.1
	skd1 protein (vacuolar sorting protein 4b). [swissprot;acc:o75351]	VPS4B	Measured		7761.01	7856.93	95.92
	smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527]	CSRP2	Rooted		69.2723	70.4088	1.1365
	triosephosphate isomerase (ec 5.3.1.1) (tim). [swissprot;acc:p00938]	TPI1		Divided	69.7447	70.8792	1.01627
	vigilin (high density lipoprotein-binding protein) (hdl-binding protein). [swissprot;acc:q00341]	HDLBP	Squared		47617.6	47057.3	1.01191
4779	60s ribosomal protein l32. [swissprot;acc:p02433]	SNORA7A	Measured	Subtracted	7365.11	7460.59	95.48
	contactin 2 precursor (axonin-1) (axonal glycoprotein tag-1) (transient axonal glycoprotein 1) (tax-1). [swissprot;acc:q02246]	CNTN2	Ranked		201.633	200.734	0.899
	contactin 5 isoform long; neural adhesion molecule. [refseq;acc:nm_014361]	CNTN5		Divided			1.00448
	heparan sulfate 6-o-sulfotransferase; heparan-sulfate 6-sulfotransferase. [refseq;acc:nm_004807]	HS6ST1	Measured		8086.46	8184.64	1.01214
	likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745]	SHCBP1	Rooted	Subtracted	69.2718	70.4081	1.1363
	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	WASL	Squared	Divided	45702.5	45169.2	1.01181
	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	RGS19	Rooted		70.5022	71.647	1.01624
	zinc binding alcohol dehydrogenase, domain containing 1. [refseq;acc:nm_152444]	ZADH1	Squared	Subtracted	51209.1	51723.9	514.8
4780	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	AMPD2			45089.2	44575.6	513.6
	contactin 5 isoform long; neural adhesion molecule. [refseq;acc:nm_014361]	CNTN5	Ranked		201.633	200.734	0.899
	contactin 6; neural adhesion molecule. [refseq;acc:nm_014461]	CNTN6		Divided			1.00448
	deltex 2. [refseq;acc:nm_020892]	DTX2	Measured	Subtracted	7790.67	7885.3	94.63
	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	DTX1		Divided	7795.48	7889.92	1.01211
	potassium voltage-gated channel subfamily kqt member 3 (potassium channel alpha subunit kvlqt3) (kqt-like 3). [swissprot;acc:o43525]	KCNQ3	Squared		45564.6	45033.4	1.0118
	protein c8orf1 (ht41). [swissprot;acc:q9y236]	OSGIN2	Rooted	Subtracted	69.3271	70.4623	1.1352
	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	RGS20		Divided	70.5022	71.647	1.01624
4781	60s ribosomal protein l3-like. [swissprot;acc:q92901]	RPL3L		Subtracted	69.3271	70.4623	1.1352
	contactin 6; neural adhesion molecule. [refseq;acc:nm_014461]	CNTN6	Ranked		201.633	200.734	0.899
	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	DTX1	Measured		7795.48	7889.92	94.44
	potassium voltage-gated channel subfamily kqt member 2 (neuroblastoma- specific potassium channel alpha subunit kvlqt2) (kqt-like 2). [swissprot;acc:o43526]	KCNQ2	Squared	Divided	45565.5	45035.2	1.01178
	putative homeodomain transcription factor 1. [swissprot;acc:q9ums5]	PHTF1	Ranked		201.633	200.734	1.00448
	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	RGS17	Rooted		70.5022	71.647	1.01624
	serine/threonine protein phosphatase pp1-alpha 1 catalytic subunit (ec 3.1.3.16) (pp-1a). [swissprot;acc:p08129]	PPP1CA	Measured		8596.04	8699.84	1.01208
	trna isopentenylpyrophosphate transferase. [refseq;acc:nm_017646]	TRIT1	Squared	Subtracted	47591.8	47088.6	503.2
4782	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	GNAO1	Rooted	Divided	70.5022	71.647	1.01624

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.