MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 636 to 685 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]	812	NAPA	High confidence	212.386	221.785	1.04425
	3626		Low confidence	203.045	200.2	1.01421
alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]	1961	ABHD1	High confidence	211.633	213.703	1.00978
	3700		Low confidence	199.865	197.151	1.01377
alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340]	1959	ABHD3	High confidence	211.633	213.703	1.00978
	3699		Low confidence	199.865	197.151	1.01377
alveolar soft part sarcoma chromosome region, candidate 1; aspl protein; renal cell carcinoma gene on chromosome 17; renal cell carcinoma, papillary, 17 gene; aspscr1/tfe3 fusion gene, included. [refseq;acc:nm_024083]	2829	ASPSCR1	High confidence	0.00001	0.00001	1
	3779		Low confidence	200.614	197.974	1.01334
amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]	637	PPAT	High confidence	228.639	242.258	1.05957
	3151		Low confidence	202.333	199.1	1.01624
amiloride-sensitive brain sodium channel bnac1 (amiloride-sensitive cation channel neuronal 1) (bnc1) (degenerin channel mdeg). [swissprot;acc:q16515]	4952	ACCN1		208.218	208.455	1.00114
amiloride-sensitive brain sodium channel bnac2 (amiloride-sensitive cation channel neuronal 2). [swissprot;acc:p78348]	4951	ACCN2
amiloride-sensitive cation channel 3 isoform a; testis sodium channel 1; proton-gated cation channel subunit; modulatory subunit of asic2a; amiloride-sensitive cation channel 3, testis. [refseq;acc:nm_004769]	4948	no value
amiloride-sensitive cation channel 5, intestinal; amiloride-sensitive sodium channel. [refseq;acc:nm_017419]	4953	ACCN5
amiloride-sensitive sodium channel alpha-subunit (epithelial na+ channel alpha subunit) (alpha enac) (nonvoltage-gated sodium channel 1 alpha subunit) (scnea) (alpha nach). [swissprot;acc:p37088]	4950	SCNN1A
amiloride-sensitive sodium channel beta-subunit (epithelial na+ channel beta subunit) (beta enac) (nonvoltage-gated sodium channel 1 beta subunit) (scneb) (beta nach) (enacb). [swissprot;acc:p51168]	4946	SCNN1B
amiloride-sensitive sodium channel delta-subunit (epithelial na+ channel delta subunit) (delta enac) (nonvoltage-gated sodium channel 1 delta subunit) (scned) (delta nach). [swissprot;acc:p51172]	4949	SCNN1D
amiloride-sensitive sodium channel gamma-subunit (epithelial na+ channel gamma subunit) (gamma enac) (nonvoltage-gated sodium channel 1 gamma subunit) (scneg) (gamma nach). [swissprot;acc:p51170]	4947	SCNN1G
amino acid transporter xat2; likely ortholog of mouse aspartate/glutamate transporter 1 (agt1). [refseq;acc:nm_138817]	95	SLC7A13		200.497	185.679	1.0798
aminoacylase-1 (ec 3.5.1.14) (n-acyl-l-amino-acid amidohydrolase) (acy-1). [swissprot;acc:q03154]	724	ACY1		201.765	196.371	1.02747
	1420		High confidence	203.979	208.229	1.02084
aminoadipate-semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase. [refseq;acc:nm_005763]	2064	AASS		207.655	205.939	1.00833
	3212		Low confidence	202.212	199.028	1.016
aminomethyltransferase, mitochondrial precursor (ec 2.1.2.10) (glycine cleavage system t protein) (gcvt). [swissprot;acc:p48728]	2544	AMT	High confidence	212.67	212.262	1.00192
	2903		Low confidence	196.135	192.845	1.01706
ammecr1 protein. [refseq;acc:nm_015365]	1577	AMMECR1	High confidence	222.585	218.982	1.01645
	2922		Low confidence	193.976	190.73	1.01702
amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	52	AMPD2	High confidence	133	105	1.26667
	799		Low confidence	201.294	196.11	1.02643
amphiphysin. [swissprot;acc:p49418]	2389	AMPH		202.089	198.416	1.01851
amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	79	APBA1		229.144	208.803	1.09742
	139		High confidence	271.752	225.68	1.20415
amyloid beta a4 protein precursor (app) (abpp) (alzheimer's disease amyloid protein) (cerebral vascular amyloid peptide) (cvap) (protease nexin-ii) (pn-ii) (appi) (prea4) [contains: soluble app-alpha (s-app- alpha); soluble app-beta (s-app-beta); c99; beta-amyloid protein 42 (beta-app42); beta-amyloid protein 40 (beta-app40); c83; p3(42); p3(40); gamma-ctf(59) (gamma-secretase c-terminal fragment 59) (amyloid intracellular domain 59) (aid(59)); gamma-ctf(57) (gamma- secretase c-terminal fragment 57) (amyloid intracellular domain 57) (aid(57)); gamma-ctf(50) (gamma-secretase c-terminal fragment 50) (amyloid intracellular domain 50) (aid(50)); c31]. [swissprot;acc:p05067]	508	APP	Low confidence	205.157	198.715	1.03242
amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905]	810	APPBP1		196.326	191.3	1.02627
	2490		High confidence	194.527	195.08	1.00284
amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail)-binding protein 2; protein interacting with app tail 1. [refseq;acc:nm_006380]	3191	APPBP2		0.00001	0.00001	1
	3371		Low confidence	200.658	197.607	1.01544
amyloid-like protein 1 precursor (aplp) (aplp-1) [contains: c30]. [swissprot;acc:p51693]	512	APLP1		205.157	198.715	1.03242
amyloid-like protein 2 precursor (amyloid protein homolog) (apph) (cdei-box binding protein) (cdebp). [swissprot;acc:q06481]	518	APLP2		205.156		1.03241
anaphase promoting complex subunit 11 (hepatocellular carcinoma associated ring finger protein) (hspc214). [swissprot;acc:q9nyg5]	2636	ANAPC11	High confidence	195.635	195.384	1.00128
	4090		Low confidence	202.978	200.781	1.01094
anaphase-promoting complex 1 (meiotic checkpoint regulator). [refseq;acc:nm_022662]	4764	ANAPC1		200.161	201.146	1.00492
anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]	207	ANAPC10		213.495	203.244	1.05044
	2663		High confidence	204.768	204.549	1.00107
anaphase-promoting complex subunit 2; anaphase-promoting complex 2. [refseq;acc:nm_013366]	2679	ANAPC2		190.142	189.959	1.00096
	4577		Low confidence	202.548	204.086	1.00759
anchor attachment protein 1; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (gaa1p, yeast) homolog. [refseq;acc:nm_003801]	1649	no value		200.535	196.468	1.0207
androgen receptor coactivator ara55; hic-5. [refseq;acc:nm_015927]	2926	TGFB1I1		204.222	200.808	1.017
androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	240	AIG1	High confidence	227.357	254.15	1.11785
	1254		Low confidence	204.026	199.515	1.02261

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.