MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

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Showing element 632 to 681 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Value Type	Hugo	red	network_comparison	green
40s ribosomal protein s3. [swissprot;acc:p23396]	Subtracted	2466	Squared	RPS3	12856.2	1191.8	14048
40s ribosomal protein s30. [swissprot;acc:q05472]	Divided	1002	Rooted	FAU	61.3513	1.05438	64.6874
		1081	Ranked		223.44	1.03027	216.875
		1145	Measured		5893.97	1.08858	6416.07
		1195	Squared		28134.5	1.13683	31984.1
	Subtracted	863				3849.6
		1025	Ranked		223.44	6.565	216.875
			Rooted		61.3513	3.3361	64.6874
		1071	Measured		5893.97	522.1	6416.07
40s ribosomal protein s3a. [swissprot;acc:p49241]	Divided	867	Ranked	no value	225.689	1.03981	234.674
		1220	Squared		19516.8	1.13635	22178
		2263	Measured		4918.64	1.0461	5145.39
		2623	Rooted		57.8256	1.00682	57.434
	Subtracted	825	Ranked		225.689	8.985	234.674
		1486	Squared		19516.8	2661.2	22178
		2330	Measured		4918.64	226.75	5145.39
		2635	Rooted		57.8256	0.3916	57.434
40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]	Divided	288	Ranked		240.758	1.10517	266.078
		362	Rooted		50.7803	1.10518	45.9477
		1930	Squared		12829.2	1.09359	14029.9
		1974	Measured		3678.62	1.05993	3470.64
	Subtracted	203	Ranked		240.758	25.32	266.078
		607	Rooted		50.7803	4.8326	45.9477
		2364	Measured		3678.62	207.98	3470.64
		2452	Squared		12829.2	1200.7	14029.9
40s ribosomal protein s4, y isoform 2. [swissprot;acc:q8td47]	Divided	287	Ranked	RPS4Y2	240.758	1.10517	266.079
		361	Rooted		50.7801	1.10518	45.9472
		1929	Squared		12828.8	1.09359	14029.4
		1967	Measured		3678.56	1.05994	3470.55
	Subtracted	202	Ranked		240.758	25.321	266.079
		606	Rooted		50.7801	4.8329	45.9472
		2363	Measured		3678.56	208.01	3470.55
		2453	Squared		12828.8	1200.6	14029.4
40s ribosomal protein s5. [swissprot;acc:p46782]	Divided	366	Ranked	RPS5	242.473	1.09602	265.756
		467	Rooted		50.4649	1.09446	46.1093
		1820	Squared		13022.7	1.09738	14290.8
		2343	Measured		3672.17	1.04413	3516.98
	Subtracted	275	Ranked		242.473	23.283	265.756
		735	Rooted		50.4649	4.3556	46.1093
		2427	Squared		13022.7	1268.1	14290.8
		2485	Measured		3672.17	155.19	3516.98
40s ribosomal protein s7 (s8). [swissprot;acc:p23821]	Divided	1561	Squared	RPS7	26174.3	1.11172	29098.4
		1642	Measured		5782.92	1.06977	6186.39
		2102	Rooted		61.9958	1.02489	63.5389
		2149	Ranked		217.871	1.00686	219.366
	Subtracted	1292	Squared		26174.3	2924.1	29098.4
		1679	Measured		5782.92	403.47	6186.39
		2111	Rooted		61.9958	1.5431	63.5389
		2126	Ranked		217.871	1.495	219.366
40s ribosomal protein s8. [swissprot;acc:p09058]	Divided	1213	Rooted	RPS8	61.4774	1.04598	64.3044

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.