MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Network Comparison Type	Hugo	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 632 to 681 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	network_comparison	green
316	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	EIF1	High confidence	242.694	1.10022	267.017
317	potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]	KCNA1	Low confidence	209.58	1.04139	201.251
	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	no value	High confidence	224.445	1.09998	204.044
318	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	MRPL3		242.011	1.09987	266.18
	potassium voltage-gated channel subfamily a member 4 (potassium channel kv1.4) (hk1) (hpcn2) (hbk4) (hukii). [swissprot;acc:p22459]	KCNA4	Low confidence	209.579	1.04138	201.251
319	60s ribosomal protein l19. [swissprot;acc:p14118]	RPL19	High confidence	240.73	1.09969	264.729
	heat-shock protein, beta-2 (hspb2) (dmpk-binding protein) (mkbp). [swissprot;acc:q16082]	HSPB2	Low confidence	212.752	1.04123	204.328
320	epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	CDH1	High confidence	241.892	1.0995	265.96
	phosphorylase b kinase gamma catalytic chain, testis/liver isoform (ec 2.7.1.38) (phk-gamma-t) (phosphorylase kinase gamma subunit 2) (psk-c3). [swissprot;acc:p15735]	PHKG2	Low confidence	217.756	1.04117	226.722
321	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	no value	High confidence	241.892	1.09949	265.959
	glioma tumor suppressor candidate region gene 2 protein (p60). [swissprot;acc:q9nzm5]	SNORD23	Low confidence	207.402	1.04108	199.219
322	cleavage and polyadenylation specific factor 5, 25 kd subunit; pre-mrna cleavage factor im (25kd); pre-mrna cleavage factor im, 25kd subunit. [refseq;acc:nm_007006]	NUDT21		212.262	1.04055	203.991
	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	DNASE2B	High confidence	86.7483	1.09948	78.8995
323	60s ribosomal protein l23a. [swissprot;acc:p29316]	no value		241.884	1.09947	265.945
	integrin beta-1 binding protein 2 (melusin) (mstp015). [swissprot;acc:q9ukp3]	ITGB1BP2	Low confidence	212.262	1.04055	203.991
324	40s ribosomal protein s23. [swissprot;acc:p39028]	RPS23	High confidence	243.944	1.09941	268.195
	rab3 gtpase-activating protein, non-catalytic subunit. [refseq;acc:nm_012414]	RAB3GAP2	Low confidence	212.262	1.04055	203.991
325	28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]	MRPS12	High confidence	243.944	1.09941	268.195
	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	STT3B	Low confidence	199.905	1.04051	192.123
326	60s ribosomal protein l5. [swissprot;acc:p46777]	RPL5	High confidence	241.899	1.09932	265.924
	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	DDOST	Low confidence	199.343	1.04047	191.59
327	bet3 homolog. [swissprot;acc:o43617]	TRAPPC3		197.221	1.04034	189.574
	dna-directed rna polymerase ii largest subunit (ec 2.7.7.6) (rpb1). [swissprot;acc:p24928]	POLR2A	High confidence	243.817	1.09903	267.962
328	atp-dependent rna helicase ddx24 (dead-box protein 24). [swissprot;acc:q9gzr7]	DDX24		258.437	1.09888	235.183
	splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]	SF3B2	Low confidence	203.162	1.04031	195.289
329	exocyst complex component exo70. [swissprot;acc:q9upt5]	EXOC7		204.124	1.04025	212.339
	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	NEUROD2	High confidence	312	1.09859	284
330	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	CHD3
	senescence marker protein-30 (smp-30) (regucalcin) (rc). [swissprot;acc:q15493]	RGN	Low confidence	221.437	1.04015	212.889
331	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	CDK2AP2	High confidence	312	1.09859	284
	udp-glucose 4-epimerase (ec 5.1.3.2) (galactowaldenase) (udp- galactose 4-epimerase). [swissprot;acc:q14376]	GALE	Low confidence	200.249	1.04007	192.535
332	dynein intermediate chain 1, cytosolic (dh ic-1) (cytoplasmic dynein intermediate chain 1). [swissprot;acc:o14576]	DYNC1I1		209.495	1.03981	201.474
	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	NEUROD6	High confidence	312	1.09859	284
333	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	NEUROD1
	protein c20orf43 (hspc164/hspc169) (ad-007) (cda05). [swissprot;acc:q9by42]	C20orf43	Low confidence	200.482	1.03972	208.446
334	coiled-coil protein bicd2; homolog of drosophila bicaudal d. [refseq;acc:nm_015250]	BICD2		202.616	1.03971	194.878
	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]	NEUROD4	High confidence	312	1.09859	284
335	bicaudal d homolog 1; bicaudal-d, drosophila, homolog of, 1. [refseq;acc:nm_001714]	BICD1	Low confidence	202.616	1.03971	194.878
	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]	CHD5	High confidence	312	1.09859	284
336	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	CDK2AP1
	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	TFIP11	Low confidence	202.616	1.03971	194.878
337	60s ribosomal protein l12. [swissprot;acc:p30050]	no value	High confidence	243.583	1.0983	267.527
	serine/threonine-protein kinase kkialre (ec 2.7.1.-) (cyclin-dependent kinase-like 1). [swissprot;acc:q00532]	CDKL1	Low confidence	201.873	1.03961	194.181
338	60s ribosomal protein l12 like protein. [sptrembl;acc:o60886]	no value	High confidence	243.583	1.0983	267.528
	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]	TXNL4A	Low confidence	202.572	1.03958	194.86
339	dj999l4.1 (novel protein similar to ribosomal protein l12 (rpl12)). [sptrembl;acc:q9nq02]	no value	High confidence	243.583	1.0983	267.527
	geranylgeranyl pyrophosphate synthetase (ggpp synthetase) (ggppsase) (geranylgeranyl diphosphate synthase) [includes: dimethylallyltransferase (ec 2.5.1.1); geranyltranstransferase (ec 2.5.1.10); farnesyltranstransferase (ec 2.5.1.29)]. [swissprot;acc:o95749]	GGPS1	Low confidence	209.518	1.03951	201.554
340	blocked early in transport 1 homolog (s. cerevisiae) like; golgi snare 15 kda protein. [refseq;acc:nm_016526]	BET1L		201.827	1.03939	194.178
	myelin gene expression factor 2. [refseq;acc:nm_016132]	MYEF2	High confidence	235.383	1.09811	258.476
341	60s ribosomal protein l9. [swissprot;acc:p32969]	no value		240.243	1.09805	263.798

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.