MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	red	Interaction Map	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 630 to 679 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	red	Interaction Map	green	network_comparison
315	TNKS	tankyrase 1 (ec 2.4.2.30) (tank1) (tankyrase i) (tnks-1) (trf1- interacting ankyrin-related adp-ribose polymerase). [swissprot;acc:o95271]	214.067	Low confidence	205.509	1.04164
316	EIF1	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	242.694	High confidence	267.017	1.10022
	KCNA2	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	209.583	Low confidence	201.251	1.0414
317	no value	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	224.445	High confidence	204.044	1.09998
	KCNA1	potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]	209.58	Low confidence	201.251	1.04139
318	KCNA4	potassium voltage-gated channel subfamily a member 4 (potassium channel kv1.4) (hk1) (hpcn2) (hbk4) (hukii). [swissprot;acc:p22459]	209.579			1.04138
	MRPL3	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	242.011	High confidence	266.18	1.09987
319	HSPB2	heat-shock protein, beta-2 (hspb2) (dmpk-binding protein) (mkbp). [swissprot;acc:q16082]	212.752	Low confidence	204.328	1.04123
	RPL19	60s ribosomal protein l19. [swissprot;acc:p14118]	240.73	High confidence	264.729	1.09969
320	CDH1	epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	241.892		265.96	1.0995
	PHKG2	phosphorylase b kinase gamma catalytic chain, testis/liver isoform (ec 2.7.1.38) (phk-gamma-t) (phosphorylase kinase gamma subunit 2) (psk-c3). [swissprot;acc:p15735]	217.756	Low confidence	226.722	1.04117
321	no value	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	241.892	High confidence	265.959	1.09949
	SNORD23	glioma tumor suppressor candidate region gene 2 protein (p60). [swissprot;acc:q9nzm5]	207.402	Low confidence	199.219	1.04108
322	DNASE2B	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	86.7483	High confidence	78.8995	1.09948
	NUDT21	cleavage and polyadenylation specific factor 5, 25 kd subunit; pre-mrna cleavage factor im (25kd); pre-mrna cleavage factor im, 25kd subunit. [refseq;acc:nm_007006]	212.262	Low confidence	203.991	1.04055
323	no value	60s ribosomal protein l23a. [swissprot;acc:p29316]	241.884	High confidence	265.945	1.09947
	ITGB1BP2	integrin beta-1 binding protein 2 (melusin) (mstp015). [swissprot;acc:q9ukp3]	212.262	Low confidence	203.991	1.04055
324	RAB3GAP2	rab3 gtpase-activating protein, non-catalytic subunit. [refseq;acc:nm_012414]
	RPS23	40s ribosomal protein s23. [swissprot;acc:p39028]	243.944	High confidence	268.195	1.09941
325	MRPS12	28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]
	STT3B	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	199.905	Low confidence	192.123	1.04051
326	DDOST	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	199.343		191.59	1.04047
	RPL5	60s ribosomal protein l5. [swissprot;acc:p46777]	241.899	High confidence	265.924	1.09932
327	POLR2A	dna-directed rna polymerase ii largest subunit (ec 2.7.7.6) (rpb1). [swissprot;acc:p24928]	243.817		267.962	1.09903
	TRAPPC3	bet3 homolog. [swissprot;acc:o43617]	197.221	Low confidence	189.574	1.04034
328	DDX24	atp-dependent rna helicase ddx24 (dead-box protein 24). [swissprot;acc:q9gzr7]	258.437	High confidence	235.183	1.09888
	SF3B2	splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]	203.162	Low confidence	195.289	1.04031
329	EXOC7	exocyst complex component exo70. [swissprot;acc:q9upt5]	204.124		212.339	1.04025
	NEUROD2	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	312	High confidence	284	1.09859
330	CHD3	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]
	RGN	senescence marker protein-30 (smp-30) (regucalcin) (rc). [swissprot;acc:q15493]	221.437	Low confidence	212.889	1.04015
331	CDK2AP2	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	312	High confidence	284	1.09859
	GALE	udp-glucose 4-epimerase (ec 5.1.3.2) (galactowaldenase) (udp- galactose 4-epimerase). [swissprot;acc:q14376]	200.249	Low confidence	192.535	1.04007
332	DYNC1I1	dynein intermediate chain 1, cytosolic (dh ic-1) (cytoplasmic dynein intermediate chain 1). [swissprot;acc:o14576]	209.495		201.474	1.03981
	NEUROD6	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	312	High confidence	284	1.09859
333	C20orf43	protein c20orf43 (hspc164/hspc169) (ad-007) (cda05). [swissprot;acc:q9by42]	200.482	Low confidence	208.446	1.03972
	NEUROD1	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	312	High confidence	284	1.09859
334	BICD2	coiled-coil protein bicd2; homolog of drosophila bicaudal d. [refseq;acc:nm_015250]	202.616	Low confidence	194.878	1.03971
	NEUROD4	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]	312	High confidence	284	1.09859
335	BICD1	bicaudal d homolog 1; bicaudal-d, drosophila, homolog of, 1. [refseq;acc:nm_001714]	202.616	Low confidence	194.878	1.03971
	CHD5	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]	312	High confidence	284	1.09859
336	CDK2AP1	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]
	TFIP11	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	202.616	Low confidence	194.878	1.03971
337	no value	60s ribosomal protein l12. [swissprot;acc:p30050]	243.583	High confidence	267.527	1.0983
	CDKL1	serine/threonine-protein kinase kkialre (ec 2.7.1.-) (cyclin-dependent kinase-like 1). [swissprot;acc:q00532]	201.873	Low confidence	194.181	1.03961
338	no value	60s ribosomal protein l12 like protein. [sptrembl;acc:o60886]	243.583	High confidence	267.528	1.0983
	TXNL4A	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]	202.572	Low confidence	194.86	1.03958
339	no value	dj999l4.1 (novel protein similar to ribosomal protein l12 (rpl12)). [sptrembl;acc:q9nq02]	243.583	High confidence	267.527	1.0983
	GGPS1	geranylgeranyl pyrophosphate synthetase (ggpp synthetase) (ggppsase) (geranylgeranyl diphosphate synthase) [includes: dimethylallyltransferase (ec 2.5.1.1); geranyltranstransferase (ec 2.5.1.10); farnesyltranstransferase (ec 2.5.1.29)]. [swissprot;acc:o95749]	209.518	Low confidence	201.554	1.03951
340	BET1L	blocked early in transport 1 homolog (s. cerevisiae) like; golgi snare 15 kda protein. [refseq;acc:nm_016526]	201.827		194.178	1.03939

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.