MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 630 to 679 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Value Type	red	green	network_comparison
158	GPSM2	mosaic protein lgn. [swissprot;acc:p81274]	Ranked	249.663	298.263	1.19466
	MAGEA6	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Measured	23693.7	18263	1.29736
	SEPT7	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Squared	89182.8	125229	1.40418
159	no value	rna-binding protein. [refseq;acc:nm_019027]	Rooted	52.7642	61.9019	1.17318
	NDN	necdin. [swissprot;acc:q99608]	Measured	23693.7	18263	1.29736
	RGS17	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	Ranked	249.663	298.263	1.19466
	SEPT6	septin 6. [swissprot;acc:q14141]	Squared	88953.6	124854	1.40359
160	no value	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	Rooted	52.7642	61.9019	1.17318
		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	Squared	173408	242989	1.40126
	GNAO1	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	Ranked	249.663	298.263	1.19466
	MAGED1	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Measured	23693.7	18263	1.29736
161	HOXB4	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	Squared	173408	242989	1.40126
	MAGEF1	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Measured	23693.7	18263	1.29736
	RAP1GAP	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	Ranked	249.663	298.263	1.19466
	SYNCRIP	ns1-associated protein 1. [refseq;acc:nm_006372]	Rooted	52.7642	61.9019	1.17318
162	HNRNPR	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]
	HOXC5	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	Squared	173408	242989	1.40126
	MAGEB6B	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Measured	23693.7	18263	1.29736
	NOSTRIN	nostrin. [refseq;acc:nm_052946]	Ranked	209.299	249.187	1.19058
163	no value	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Squared	173408	242989	1.40126
		melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Measured	23693.7	18263	1.29736
	EIF4G1	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	Rooted	52.7702	61.8915	1.17285
	SNF8	eap30 subunit of ell complex. [refseq;acc:nm_007241]	Ranked	209.299	249.187	1.19058
164	HOXD4	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	Squared	173408	242989	1.40126
	MAGEA9	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Measured	23693.7	18263	1.29736
	MXD1	mad protein (max dimerizer). [swissprot;acc:q05195]	Rooted	55.646	65.1534	1.17086
	SLC39A6	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	Ranked	209.299	249.187	1.19058
165	GAD2	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]
	HOXB5	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Squared	173408	242989	1.40126
	MAGEA8	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Measured	23693.7	18263	1.29736
	MXI1	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	Rooted	55.6486	65.1478	1.1707
166	HOXA5	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Squared	173408	242989	1.40126
	MAGEC1	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Measured	23693.7	18263	1.29736
	MXD4	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	Rooted	55.6495	65.1458	1.17064
	NAPG	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	Ranked	209.299	249.187	1.19058
167	no value	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	Squared	173408	242989	1.40126
	GAD1	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	Ranked	209.299	249.187	1.19058
	MAGEA4	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Measured	23693.7	18263	1.29736
	RAB24	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	Rooted	55.65	65.1448	1.17062
168	no value	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	Ranked	82.5916	98.0548	1.18722
		melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Measured	23693.7	18263	1.29736
	HSD17B14	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	Squared	173408	242989	1.40126
	SNRPD3	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	Rooted	56.3709	65.8949	1.16895
169	ATG3	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	Ranked	82.5916	98.0548	1.18722
	COPS3	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	Rooted	62.762	53.7761	1.1671
	MAGEA10	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Measured	23693.7	18263	1.29736
	SYMPK	symplekin. [swissprot;acc:q92797]	Squared	124118	88668.8	1.39979
170	B9D1	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	Rooted	53.4993	45.9227	1.16499
	CTPS2	cytidine triphosphate synthase ii; ctp synthetase type 2; utp-ammonia ligase; ctp synthetase isoform; cytidine 5'-triphosphate synthetase 2. [refseq;acc:nm_019857]	Squared	96730.5	69286.7	1.39609
	MAGEB4	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Measured	23693.7	18263	1.29736

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.