MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Network Comparison Type	Value Type	red	Interaction Map	Filtered	network_comparison	green

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Showing element 630 to 679 of 66312 in total

Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Value Type	red	Interaction Map	network_comparison	green
26s proteasome non-atpase regulatory subunit 6 (26s proteasome regulatory subunit s10) (p42a) (proteasome regulatory particle subunit p44s10). [swissprot;acc:q15008]	2432	PSMD6	Divided	Ranked	215.807	High confidence	1.00347	216.556
	4467		Subtracted	Squared	45789.8	Low confidence	928.6	44861.2
	4516		Divided				1.0207
26s proteasome non-atpase regulatory subunit 7 (26s proteasome regulatory subunit s12) (proteasome subunit p40) (mov34 protein homolog). [swissprot;acc:p51665]	1259	PSMD7	Subtracted		26642.1	High confidence	2980	29622.1
	1554		Divided				1.11185
	1571			Measured	5851.64		1.07208	6273.4
	1625		Subtracted				421.76
	2010			Rooted	62.3398		1.7064	64.0462
	2013		Divided				1.02737
	2350		Subtracted	Ranked	217.232		0.93	218.162
	2355		Divided				1.00428
	2456		Subtracted	Measured	8117.3	Low confidence	241.3	8358.6
	2648		Divided				1.02973
	2849		Subtracted	Rooted	72.6295		2.3453	74.9748
	2952		Divided				1.03229
	3198			Ranked	200.29		1.01604	197.129
	3219		Subtracted				3.161
	3462			Squared	46162.3		1414.9	44747.4
	3621		Divided				1.03162
26s proteasome non-atpase regulatory subunit 8 (26s proteasome regulatory subunit s14) (p31). [swissprot;acc:p48556]	865	PSMD8	Subtracted	Measured	8126.23		319.16	8445.39
	917		Divided				1.03928
	1131		Subtracted	Rooted	72.7208		2.7682	75.489
	1168		Divided				1.03807
	1344		Subtracted	Squared	27060.6	High confidence	2856.2	29916.8
	1532			Measured	5916.05		434.48	6350.53
	1536		Divided				1.07344
	1691			Squared	27060.6		1.10555	29916.8
	1798			Ranked	200.037	Low confidence	1.02014	196.088
	1813		Subtracted				3.949
	1861		Divided	Rooted	62.7784	High confidence	1.02965	64.64
	1882		Subtracted				1.8616
	2519			Ranked	215.835		0.506	216.341
	2525		Divided				1.00234
	4414		Subtracted	Squared	46044.6	Low confidence	979.5	45065.1
	4452		Divided				1.02174
26s proteasome non-atpase regulatory subunit 9 (26s proteasome regulatory subunit p27). [swissprot;acc:o00233]	1232	PSMD9	Subtracted		27762.4	High confidence	3001.5	30763.9
	1340			Measured	8155.72	Low confidence	279.68	8435.4
	1454		Divided				1.03429
	1460		Subtracted		5996.14	High confidence	443.32	6439.46
	1517		Divided				1.07393
	1628			Squared	27762.4		1.10811	30763.9
	1688		Subtracted	Rooted	72.7463	Low confidence	2.5879	75.3342
	1799		Divided				1.03557
	1813		Subtracted		63.0811	High confidence	1.9153	64.9964
	1831		Divided				1.03036
	2077			Ranked	200.371	Low confidence	1.01928	196.58
	2100		Subtracted				3.791
	2620		Divided		215.615	High confidence	1.00137	215.91
	2627		Subtracted				0.295
	3915			Squared	46483.1	Low confidence	1242.9	45240.2

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.