MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 60374 to 60423 of 66312 in total

Interaction Map  : Low confidence
Filtered  : 1

Rank	Hugo	description	Value Type	Network Comparison Type	red	network_comparison	green
4319	TIMM10	mitochondrial import inner membrane translocase subunit tim10. [swissprot;acc:q9y5j8]	Rooted	Subtracted	71.7534	1.8371	73.5905
	ZNF19	zinc finger protein 19 (zinc finger protein kox12) (fragment). [swissprot;acc:p17023]		Divided	76.1821	1.02447	78.0464
	ZNF771	mesenchymal stem cell protein dsc43. [refseq;acc:nm_016643]	Ranked	Subtracted	197.793	1.83	195.963
4320	no value	zinc finger protein 286. [swissprot;acc:q9hbt8]	Rooted	Divided	76.1821	1.02447	78.0464
		zinc finger protein 44 (zinc finger protein kox7) (gonadotropin inducible transcription repressor-2) (giot-2). [swissprot;acc:p15621]	Ranked		197.793	1.00934	195.963
		zinc finger protein 73 (zinc finger protein 186) (hznf2). [swissprot;acc:o43830]		Subtracted		1.83
	ACTN2	alpha-actinin 2 (alpha actinin skeletal muscle isoform 2) (f-actin cross linking protein). [swissprot;acc:p35609]	Squared		43291.3	1052.6	42238.7
	OSTF1	osteoclast stimulating factor 1. [swissprot;acc:q92882]	Rooted		70.8411	1.8355	72.6766
	PTP4A3	protein tyrosine phosphatase type iva, member 3 isoform 2; potentially prenylated protein tyrosine phosphatase. [refseq;acc:nm_007079]	Measured		8224.26	164.15	8388.41
	SNRPA1	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	Squared	Divided	43548.6	1.02405	42526
	ZNF180	zinc finger protein 180 (hhz168). [swissprot;acc:q9ujw8]	Measured		9143.35	1.01967	9323.2
4321	HNRPH1	heterogeneous nuclear ribonucleoprotein h (hnrnp h). [swissprot;acc:p31943]	Squared		39371.9	1.02402	38448.2
	NUAK1	probable serine/threonine-protein kinase kiaa0537 (ec 2.7.1.-). [swissprot;acc:o60285]	Rooted	Subtracted	71.7522	1.8353	73.5875
	PTP4A2	protein tyrosine phosphatase type iva, member 2 isoform 1; protein tyrosine phosphatase iva2; protein tyrosine phosphatase iva; phosphatase of regenerating liver 2. [refseq;acc:nm_003479]	Measured		8224.26	164.15	8388.41
	SCO1	sco1 protein homolog, mitochondrial precursor. [swissprot;acc:o75880]	Squared		44624.1	1050.5	43573.6
	ZNF117	zinc finger protein 117 (zinc finger protein hpf9) (fragment). [swissprot;acc:q03924]	Rooted	Divided	76.1821	1.02447	78.0464
	ZNF223	zinc finger protein 223. [swissprot;acc:q9uk11]	Ranked	Subtracted	197.793	1.83	195.963
	ZNF226	zinc finger protein 226. [swissprot;acc:q9nyt6]	Measured	Divided	9143.35	1.01967	9323.19
	ZNF350	zinc finger protein 350; zinc-finger protein zbrk1. [refseq;acc:nm_021632]	Ranked		197.793	1.00934	195.963
4322	SPOCK2	testican-2 precursor. [swissprot;acc:q92563]	Rooted	Subtracted	63.6966	1.8352	61.8614
	SPON2	spondin 2, extracellular matrix protein. [refseq;acc:nm_012445]	Measured		8224.26	164.15	8388.41
	TST	thiosulfate sulfurtransferase (ec 2.8.1.1) (rhodanese). [swissprot;acc:q16762]	Squared	Divided	48087	1.024	46959.8
	XPNPEP1	x-prolyl aminopeptidase (aminopeptidase p) 1, soluble; x-prolyl aminopeptidase (aminopeptidase p) 1; x-prolyl aminopeptidase (aminopeptidase p)-like. [refseq;acc:nm_020383]		Subtracted	47386	1049.8	46336.2
	ZNF23	zinc finger protein 23 (zinc finger protein 359) (zinc finger protein kox16). [swissprot;acc:p17027]	Measured	Divided	9143.35	1.01967	9323.2
	ZNF256	zinc finger protein 256 (bone marrow zinc finger 3) (bmzf-3). [swissprot;acc:q9y2p7]	Rooted		76.1821	1.02447	78.0464
	ZNF354B	zinc finger protein 354b. [refseq;acc:nm_058230]	Ranked	Subtracted	197.793	1.83	195.963
	ZNF415	zinc finger protein 415. [refseq;acc:nm_018355]		Divided		1.00934
4323	no value	zinc finger protein 126 (hzf-2) (fragment). [swissprot;acc:p35275]		Subtracted		1.83
	MPST	3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	Squared	Divided	48087	1.024	46959.8
	PDPK1	3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	Rooted	Subtracted	70.109	1.8334	71.9424
	PTP4A1	protein tyrosine phosphatase type iva, member 1; protein tyrosine phosphatase iva1. [refseq;acc:nm_003463]	Measured		8224.26	164.15	8388.41
	VPS26A	vacuolar protein sorting 26 (vesicle protein sorting 26) (hvps26). [swissprot;acc:o75436]	Squared		44444.9	1045.5	43399.4
	ZNF160	zinc finger protein 347 (zinc finger 1111). [swissprot;acc:q96se7]	Ranked	Divided	197.793	1.00934	195.963
	ZNF214	zinc finger protein 214 (bwscr2 associated zinc-finger protein 1) (baz 1). [swissprot;acc:q9ul59]	Rooted		76.1821	1.02447	78.0464
	ZNF91	zinc finger protein 257 (bone marrow zinc finger 4) (bmzf-4). [swissprot;acc:q9y2q1]	Measured		9143.35	1.01967	9323.2
4324	no value	zinc finger protein 230 (zinc finger protein fdzf2). [swissprot;acc:q9uie0]	Ranked		197.793	1.00934	195.963
		zinc finger protein 28 homolog (zfp-28) (kruppel-like zinc finger factor x6). [swissprot;acc:q8nhy6]	Measured		9143.35	1.01967	9323.2
	DAAM1	dishevelled-associated activator of morphogenesis 1. [refseq;acc:nm_014992]	Squared		45112.9	1.024	44055.6
	HMOX2	heme oxygenase 2 (ec 1.14.99.3) (ho-2). [swissprot;acc:p30519]	Measured	Subtracted	8224.26	164.15	8388.41
	OSGEPL1	putative sialoglycoprotease type 2. [refseq;acc:nm_022353]	Squared		46572.7	1043	45529.7
	PCMT1	protein-l-isoaspartate(d-aspartate) o-methyltransferase (ec 2.1.1.77) (protein-beta-aspartate methyltransferase) (pimt) (protein l- isoaspartyl/d-aspartyl methyltransferase) (l-isoaspartyl protein carboxyl methyltransferase). [swissprot;acc:p22061]	Rooted		70.109	1.8334	71.9424
	ZNF454	zinc finger protein 454. [refseq;acc:nm_182594]	Ranked		197.793	1.83	195.963
	ZNF7	zinc finger protein 7 (zinc finger protein kox4) (zinc finger protein hf.16). [swissprot;acc:p17097]	Rooted	Divided	76.1821	1.02447	78.0464
4325	no value	prefoldin subunit 6 (protein ke2). [swissprot;acc:o15212]	Squared	Subtracted	45364.9	1042.1	44322.8
		zinc finger protein 134. [swissprot;acc:p52741]	Measured	Divided	9143.34	1.01967	9323.19
	C11orf30	emsy protein. [refseq;acc:nm_020193]	Rooted	Subtracted	70.1775	1.8319	72.0094
	HMOX1	heme oxygenase 1 (ec 1.14.99.3) (ho-1). [swissprot;acc:p09601]	Measured		8224.26	164.15	8388.41
	PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	Squared	Divided	28662.5	1.02399	27991
	ZNF16	zinc finger protein clone 647. [swissprot;acc:p15622]	Ranked		197.793	1.00934	195.963
	ZNF354C	zinc finger protein 354c; krab-zinc finger protein synten. [refseq;acc:nm_014594]		Subtracted		1.83

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.