MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2025 to 2074 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
1013	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	Divided	5791.82	6340.86	1.0948
	protein cdc27hs (cell division cycle protein 27 homolog) (h-nuc). [swissprot;acc:p30260]	Subtracted	5210.58	5749.33	538.75
1014	synapsin ii. [swissprot;acc:q92777]	Divided	5791.82	6340.86	1.0948
	uridine kinase-like 1. [swissprot;acc:q9nwz5]	Subtracted	5548.78	6086.89	538.11
1015	acetyl-coa carboxylase 2 (ec 6.4.1.2) (acc-beta) [includes: biotin carboxylase (ec 6.3.4.14)]. [swissprot;acc:o00763]		7237.39	7775.21	537.82
	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	Divided	5791.82	6340.86	1.0948
1016	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]
	rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]	Subtracted	3889.27	4426.74	537.47
1017	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]	Divided	5791.82	6340.86	1.0948
	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	Subtracted	3889.27	4426.74	537.47
1018	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]
	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]	Divided	5791.82	6340.86	1.0948
1019	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]
	nicotinate-nucleotide pyrophosphorylase [carboxylating] (ec 2.4.2.19) (quinolinate phosphoribosyltransferase [decarboxylating]) (qaprtase) (qprtase). [swissprot;acc:q15274]	Subtracted	5704	6241.36	537.36
1020	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]	Divided	5791.82	6340.86	1.0948
	serine/threonine protein phosphatase 6 (ec 3.1.3.16) (pp6). [swissprot;acc:o00743]	Subtracted	7234.61	7771.58	536.97
1021	sporulation-induced transcript 4-associated protein. [refseq;acc:nm_018312]
	synapsin i (brain protein 4.1). [swissprot;acc:p17600]	Divided	5791.82	6340.86	1.0948
1022	protein kinase clk2 (ec 2.7.1.-) (cdc-like kinase 2). [swissprot;acc:p49760]		6435.94	7045.75	1.09475
	tetratricopeptide repeat protein 4 (my044 protein). [swissprot;acc:o95801]	Subtracted	6783.78	7320.39	536.61
1023	acetyl-coa carboxylase 1 (ec 6.4.1.2) (acc-alpha) [includes: biotin carboxylase (ec 6.3.4.14)]. [swissprot;acc:q13085]		7232.14	7768.35	536.21
	protein kinase clk3 (ec 2.7.1.-) (cdc-like kinase 3). [swissprot;acc:p49761]	Divided	6435.02	7044.65	1.09474
1024	cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]		5706.5	6245.55	1.09446
	topoisomerase-related function protein 4-2. [refseq;acc:nm_022447]	Subtracted	4725.28	5261.06	535.78
1025	nadph:adrenodoxin oxidoreductase, mitochondrial precursor (ec 1.18.1.2) (adrenodoxin reductase) (ar) (ferredoxin-nadp(+) reductase). [swissprot;acc:p22570]		5947.53	6481.56	534.03
	phosphomannomutase 2 (ec 5.4.2.8) (pmm 2). [swissprot;acc:o15305]	Divided	5511.96	6031.95	1.09434
1026	limbic system-associated membrane protein precursor (lsamp). [swissprot;acc:q13449]	Subtracted	5396.36	5929.41	533.05
	phosphomannomutase 1 (ec 5.4.2.8) (pmm 1) (pmmh-22). [swissprot;acc:q92871]	Divided	5509.89	6029.29	1.09427
1027	opioid binding protein/cell adhesion molecule precursor (obcam) (opioid-binding cell adhesion molecule) (opcml). [swissprot;acc:q14982]	Subtracted	5406.5	5939.42	532.92
	s-adenosylmethionine synthetase gamma form (ec 2.5.1.6) (methionine adenosyltransferase) (adomet synthetase) (mat-ii). [swissprot;acc:p31153]	Divided	6123.15	6700.05	1.09422
1028	neurotrimin precursor (hnt). [swissprot;acc:q9p121]	Subtracted	5413.63	5946.46	532.83
	nicotinate-nucleotide pyrophosphorylase [carboxylating] (ec 2.4.2.19) (quinolinate phosphoribosyltransferase [decarboxylating]) (qaprtase) (qprtase). [swissprot;acc:q15274]	Divided	5704	6241.36	1.09421
1029	beta-catenin (pro2286). [swissprot;acc:p35222]		5635.26	6166.09	1.0942
	polymerase (dna directed) sigma; topoisomerase-related function protein 4-1; polymerase (dna-directed) sigma. [refseq;acc:nm_006999]	Subtracted	4726.38	5258.95	532.57
1030	casein kinase i, epsilon isoform (ec 2.7.1.-) (cki-epsilon) (ckie). [swissprot;acc:p49674]	Divided	5048.33	5523.85	1.09419
	electron transfer flavoprotein alpha-subunit, mitochondrial precursor (alpha-etf). [swissprot;acc:p13804]	Subtracted	7919.76	8452.01	532.25
1031	membrane protein expressed in epithelial-like lung adenocarcinoma. [refseq;acc:nm_024792]	Divided	6136.99	6714.98	1.09418
	peroxisomal membrane protein 2 (22 kda peroxisomal membrane protein). [swissprot;acc:q9nr77]	Subtracted	6437.99	6969.67	531.68
1032	heat shock-related 70 kda protein 2 (heat shock 70 kda protein 2). [swissprot;acc:p54652]
	ran binding protein 11. [refseq;acc:nm_016338]	Divided	6138.91	6717.05	1.09418
1033	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]		6080.91	6653.52	1.09417
	heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [swissprot;acc:p08107]	Subtracted	6437.99	6969.67	531.68
1034	heat shock cognate 71 kda protein. [swissprot;acc:p11142]
	s-adenosylmethionine synthetase alpha and beta forms (ec 2.5.1.6) (methionine adenosyltransferase) (adomet synthetase) (mat-i/iii). [swissprot;acc:q00266]	Divided	6152.88	6732.12	1.09414
1035	beta-catenin (pro2286). [swissprot;acc:p35222]	Subtracted	5635.26	6166.09	530.83
	casein kinase i, delta isoform (ec 2.7.1.-) (cki-delta) (ckid). [swissprot;acc:p48730]	Divided	5054.73	5530.23	1.09407
1036	fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467]		6077.65	6649.22	1.09404
	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]	Subtracted	5910.54	6440.58	530.04
1037	monoglyceride lipase; lysophospholipase-like. [refseq;acc:nm_007283]	Divided	6544.26	7159.43	1.094
	phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]	Subtracted	5910.54	6440.58	530.04

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.