MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	red	Filtered	network_comparison	green

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Showing element 59874 to 59923 of 66312 in total

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description	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	red	network_comparison	green
trs85 homolog. [swissprot;acc:q9y2l5]	Divided	259	Squared	KIAA1012	Low confidence	50448.8	1.09045	46264.1
		263	Measured		High confidence	24896.4	1.21852	20431.7
		600	Rooted			138.375	1.08168	127.926
		851	Ranked			107.842	1.04161	112.329
		4150			Low confidence	200.724	1.01057	198.625
		4466	Rooted			73.2039	1.02322	74.9037
		4890	Measured			8389.61	1.00724	8450.36
	Subtracted	37	Squared		High confidence	227160	81081	146079
		47	Measured			24896.4	4464.7	20431.7
		202	Rooted			138.375	10.449	127.926
		261	Squared		Low confidence	50448.8	4184.7	46264.1
		1371	Ranked		High confidence	107.842	4.487	112.329
		4164			Low confidence	200.724	2.099	198.625
		4448	Rooted			73.2039	1.6998	74.9037
		4887	Measured			8389.61	60.75	8450.36
trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169]	Divided	431	Ranked	TRUB1	High confidence	236.245	1.07987	255.113
		859	Rooted			53.3429	1.06257	50.2017
		1309	Squared			15397.3	1.12866	17378.3
		2671			Low confidence	40982.2	1.03747	39502.1
		2698	Measured		High confidence	4163.36	1.0042	4145.95
		3995	Ranked		Low confidence	209.294	1.0118	211.763
		4582	Measured			7337.1	1.01726	7463.75
		4866	Rooted			68.4055	1.01258	69.266
	Subtracted	383	Ranked		High confidence	236.245	18.868	255.113
		1091	Rooted			53.3429	3.1412	50.2017
		2032	Squared			15397.3	1981	17378.3
		2736	Measured			4163.36	17.41	4145.95
		3212	Squared		Low confidence	40982.2	1480.1	39502.1
		3944	Ranked			209.294	2.469	211.763
		4654	Measured			7337.1	126.65	7463.75
		4874	Rooted			68.4055	0.8605	69.266
trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]	Divided	12		PRSS1		32.2966	1.48549	47.9763
		15	Measured			1983.91	1.51612	3007.85
		20	Ranked			304.359	1.23354	246.737
		4591	Squared			9206.82	1.01827	9374.99
	Subtracted	12	Ranked			304.359	57.622	246.737
		19	Rooted			32.2966	15.6797	47.9763
		69	Measured			1983.91	1023.94	3007.85
		4947	Squared			9206.82	168.17	9374.99
trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]	Divided	11	Rooted	PRSS3		32.2231	1.48738	47.928
		14	Measured			1972.65	1.51983	2998.1
		19	Ranked			304.548	1.23387	246.824
		4576	Squared			9136.66	1.01881	9308.54
	Subtracted	11	Ranked			304.548	57.724	246.824
		18	Rooted			32.2231	15.7049	47.928
		68	Measured			1972.65	1025.45	2998.1
		4945	Squared			9136.66	171.88	9308.54
tryptophan 2,3-dioxygenase (ec 1.13.11.11) (tryptophan pyrrolase) (tryptophanase) (tryptophan oxygenase) (tryptamin 2,3-dioxygenase) (trpo). [swissprot;acc:p48775]	Divided	541	Rooted	TDO2		71.0407	1.04441	74.1958
		638	Measured			7720	1.0447	8065.07
		685	Ranked			201.719	1.02808	196.209

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.