MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	description	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 5858 to 5907 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
2929	LYST	lysosomal trafficking regulator (beige homolog). [swissprot;acc:q99698]	High confidence	0.00001	0.00001	1
2930	AKT2	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]	Low confidence	204.169	200.756	1.017
	ILF2	interleukin enhancer binding factor 2; nuclear factor of activated t-cells, 45-kda. [refseq;acc:nm_004515]	High confidence	0.00001	0.00001	1
2931	CCDC130	9 kda protein. [swissprot;acc:p13994]	Low confidence	204.222	200.808	1.017
	TPM3	tropomyosin alpha 3 chain (tropomyosin 3) (tropomyosin gamma). [swissprot;acc:p06753]	High confidence	0.00001	0.00001	1
2932	POGZ	pogo transposable element with znf domain isoform 1. [refseq;acc:nm_015100]
	USP14	ubiquitin carboxyl-terminal hydrolase 14 (ec 3.1.2.15) (ubiquitin thiolesterase 14) (ubiquitin-specific processing protease 14) (deubiquitinating enzyme 14). [swissprot;acc:p54578]	Low confidence	199.891	196.55	1.017
2933	PPP1R2	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]		192.582	189.365	1.01699
	SEMA6C	semaphorin 6c precursor (semaphorin y) (sema y). [swissprot;acc:q9h3t2]	High confidence	0.00001	0.00001	1
2934	PPOX	protoporphyrinogen oxidase (ec 1.3.3.4) (ppo). [swissprot;acc:p50336]
	SAP30	sin3 associated polypeptide p30; sin3-associated polypeptide, 30kd. [refseq;acc:nm_003864]	Low confidence	207.152	203.692	1.01699
2935	CARHSP1	calcium-regulated heat-stable protein (24kd); calcium regulated heat stable protein 1 (24kd). [refseq;acc:nm_014316]		200.81	197.455
	TMCO1	putative membrane protein. [refseq;acc:nm_019026]	High confidence	0.00001	0.00001	1
2936	RXRG	retinoic acid receptor rxr-gamma. [swissprot;acc:p48443]
	SNX15	sorting nexin 15. [swissprot;acc:q9nrs6]	Low confidence	200.53	197.18	1.01699
2937	MOBKL2C	similar to mob-lak. [refseq;acc:nm_145279]	High confidence	0.00001	0.00001	1
	PABPN1	poly(a) binding protein, nuclear 1; oculopharyngeal muscular dystrophy; poly(a)-binding protein, nuclear 1; poly(a) binding protein ii; poly(a) binding protein 2. [refseq;acc:nm_004643]	Low confidence	204.908	201.484	1.01699
2938	CYR61	cyr61 protein precursor (cysteine-rich, angiogenic inducer, 61) (insulin-like growth factor-binding protein 10) (gig1 protein). [swissprot;acc:o00622]	High confidence	0.00001	0.00001	1
	PDLIM5	lim protein (similar to rat protein kinase c-binding enigma); enigma homolog. [refseq;acc:nm_006457]	Low confidence	204.219	200.809	1.01698
2939	FBN3	fibrillin 3. [refseq;acc:nm_032447]	High confidence	0.00001	0.00001	1
	MYO7A	myosin viia. [swissprot;acc:q13402]	Low confidence	198.396	195.084	1.01698
2940	no value	transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884]	High confidence	0.00001	0.00001	1
	PRPF3	u4/u6-associated rna splicing factor. [refseq;acc:nm_004698]	Low confidence	202.722	199.338	1.01698
2941	COG6	conserved oligomeric golgi complex component 6. [swissprot;acc:q9y2v7]		200.603	197.255	1.01697
	TAF4B	transcription initiation factor tfiid 105 kda subunit (tafii-105) (tafii105) (fragment). [swissprot;acc:q92750]	High confidence	0.00001	0.00001	1
2942	no value	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	Low confidence	205.861	202.426	1.01697
	SS18	ssxt protein (synovial sarcoma, translocated to x chromosome) (syt protein). [swissprot;acc:q15532]	High confidence	0.00001	0.00001	1
2943	BMP7	bone morphogenetic protein 7 precursor (bmp-7) (osteogenic protein 1) (op-1). [swissprot;acc:p18075]	Low confidence	203.455	200.059	1.01697
	PRPSAP2	phosphoribosyl pyrophosphate synthetase-associated protein 2 (prpp synthetase-associated protein 2) (41 kda phosphoribosypyrophosphate synthetase-associated protein) (pap41). [swissprot;acc:o60256]	High confidence	0.00001	0.00001	1
2944	MDH1	malate dehydrogenase, cytoplasmic (ec 1.1.1.37). [swissprot;acc:p40925]	Low confidence	202.952	199.567	1.01696
	TIGD7	tigger transposable element derived 7; jerky (mouse) homolog-like. [refseq;acc:nm_033208]	High confidence	0.00001	0.00001	1
2945	CAV3	caveolin-3 (m-caveolin). [swissprot;acc:p56539]	Low confidence	203.908	200.509	1.01695
	TPM1	tropomyosin 1 alpha chain (alpha-tropomyosin). [swissprot;acc:p09493]	High confidence	0.00001	0.00001	1
2946	no value	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]	Low confidence	201.156	197.804	1.01695
	GTF2A2	transcription initiation factor iia gamma chain (tfiia p12 subunit) (tfiia-12) (tfiias) (tfiia-gamma). [swissprot;acc:p52657]	High confidence	0.00001	0.00001	1
2947	GCH1	gtp cyclohydrolase i (ec 3.5.4.16) (gtp-ch-i). [swissprot;acc:p30793]	Low confidence	199.54	196.215	1.01695
	SERF2	small edrk-rich factor 2. [refseq;acc:nm_005770]	High confidence	0.00001	0.00001	1
2948	CAV1	caveolin-1. [swissprot;acc:q03135]	Low confidence	203.908	200.509	1.01695
	TCF12	transcription factor 12 (transcription factor htf-4) (e-box-binding protein) (dna-binding protein htf4). [swissprot;acc:q99081]	High confidence	0.00001	0.00001	1
2949	CNOT3	ccr4-not transcription complex, subunit 3; not3 (negative regulator of transcription 3, yeast) homolog. [refseq;acc:nm_014516]	Low confidence	203.908	200.509	1.01695
	MFAP1	microfibrillar-associated protein 1. [swissprot;acc:p55081]	High confidence	0.00001	0.00001	1
2950	IKBKAP	ikappab kinase complex-associated protein (ikk complex-associated protein) (p150). [swissprot;acc:o95163]	Low confidence	203.952	200.552	1.01695
	TEGT	bax inhibitor-1 (bi-1) (testis enhanced gene transcript). [swissprot;acc:p55061]	High confidence	0.00001	0.00001	1
2951	ITGB7	integrin beta-7 precursor. [swissprot;acc:p26010]
	PPIB	peptidyl-prolyl cis-trans isomerase b precursor (ec 5.2.1.8) (ppiase) (rotamase) (cyclophilin b) (s-cyclophilin) (scylp) (cyp-s1). [swissprot;acc:p23284]	Low confidence	201.735	198.377	1.01693
2952	no value	pin2-interacting protein x1 (trf1-interacting protein 1) (liver- related putative tumor suppressor) (67-11-3 protein). [swissprot;acc:q96bk5]		201.653	198.296
	ACVRL1	serine/threonine-protein kinase receptor r3 precursor (ec 2.7.1.37) (skr3) (activin receptor-like kinase 1) (alk-1) (tgf-b superfamily receptor type i) (tsr-i). [swissprot;acc:p37023]	High confidence	0.00001	0.00001	1
2953	GLIPR1	glioma pathogenesis-related protein (glipr) (rtvp-1 protein). [swissprot;acc:p48060]
	UBE2A	ubiquitin-conjugating enzyme e2 a (ec 6.3.2.19) (ubiquitin-protein ligase a) (ubiquitin carrier protein a) (hr6a) (hhr6a). [swissprot;acc:p49459]	Low confidence	198.365	195.063	1.01693
2954	INPP1	inositol polyphosphate 1-phosphatase (ec 3.1.3.57) (ippase) (ipp). [swissprot;acc:p49441]		201.71	198.354	1.01692

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.