MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Network Comparison Type	Gene	Hugo	Value Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 5858 to 5907 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Network Comparison Type	Hugo	description	red	green	network_comparison
2929	Subtracted	LYST	lysosomal trafficking regulator (beige homolog). [swissprot;acc:q99698]	0	0	0
2930	Divided	ILF2	interleukin enhancer binding factor 2; nuclear factor of activated t-cells, 45-kda. [refseq;acc:nm_004515]	0.00001	0.00001	1
	Subtracted			0	0	0
2931	Divided	TPM3	tropomyosin alpha 3 chain (tropomyosin 3) (tropomyosin gamma). [swissprot;acc:p06753]	0.00001	0.00001	1
	Subtracted			0	0	0
2932	Divided	POGZ	pogo transposable element with znf domain isoform 1. [refseq;acc:nm_015100]	0.00001	0.00001	1
	Subtracted			0	0	0
2933	Divided	SEMA6C	semaphorin 6c precursor (semaphorin y) (sema y). [swissprot;acc:q9h3t2]	0.00001	0.00001	1
	Subtracted			0	0	0
2934	Divided	PPOX	protoporphyrinogen oxidase (ec 1.3.3.4) (ppo). [swissprot;acc:p50336]	0.00001	0.00001	1
	Subtracted			0	0	0
2935	Divided	TMCO1	putative membrane protein. [refseq;acc:nm_019026]	0.00001	0.00001	1
	Subtracted			0	0	0
2936	Divided	RXRG	retinoic acid receptor rxr-gamma. [swissprot;acc:p48443]	0.00001	0.00001	1
	Subtracted			0	0	0
2937	Divided	MOBKL2C	similar to mob-lak. [refseq;acc:nm_145279]	0.00001	0.00001	1
	Subtracted			0	0	0
2938	Divided	CYR61	cyr61 protein precursor (cysteine-rich, angiogenic inducer, 61) (insulin-like growth factor-binding protein 10) (gig1 protein). [swissprot;acc:o00622]	0.00001	0.00001	1
	Subtracted			0	0	0
2939	Divided	FBN3	fibrillin 3. [refseq;acc:nm_032447]	0.00001	0.00001	1
	Subtracted			0	0	0
2940	Divided	no value	transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884]	0.00001	0.00001	1
	Subtracted			0	0	0
2941	Divided	TAF4B	transcription initiation factor tfiid 105 kda subunit (tafii-105) (tafii105) (fragment). [swissprot;acc:q92750]	0.00001	0.00001	1
	Subtracted			0	0	0
2942	Divided	SS18	ssxt protein (synovial sarcoma, translocated to x chromosome) (syt protein). [swissprot;acc:q15532]	0.00001	0.00001	1
	Subtracted			0	0	0
2943	Divided	PRPSAP2	phosphoribosyl pyrophosphate synthetase-associated protein 2 (prpp synthetase-associated protein 2) (41 kda phosphoribosypyrophosphate synthetase-associated protein) (pap41). [swissprot;acc:o60256]	0.00001	0.00001	1
	Subtracted			0	0	0
2944	Divided	TIGD7	tigger transposable element derived 7; jerky (mouse) homolog-like. [refseq;acc:nm_033208]	0.00001	0.00001	1
	Subtracted			0	0	0
2945	Divided	TPM1	tropomyosin 1 alpha chain (alpha-tropomyosin). [swissprot;acc:p09493]	0.00001	0.00001	1
	Subtracted			0	0	0
2946	Divided	GTF2A2	transcription initiation factor iia gamma chain (tfiia p12 subunit) (tfiia-12) (tfiias) (tfiia-gamma). [swissprot;acc:p52657]	0.00001	0.00001	1
	Subtracted			0	0	0
2947	Divided	SERF2	small edrk-rich factor 2. [refseq;acc:nm_005770]	0.00001	0.00001	1
	Subtracted			0	0	0
2948	Divided	TCF12	transcription factor 12 (transcription factor htf-4) (e-box-binding protein) (dna-binding protein htf4). [swissprot;acc:q99081]	0.00001	0.00001	1
	Subtracted			0	0	0
2949	Divided	MFAP1	microfibrillar-associated protein 1. [swissprot;acc:p55081]	0.00001	0.00001	1
	Subtracted			0	0	0
2950	Divided	TEGT	bax inhibitor-1 (bi-1) (testis enhanced gene transcript). [swissprot;acc:p55061]	0.00001	0.00001	1
	Subtracted			0	0	0
2951	Divided	ITGB7	integrin beta-7 precursor. [swissprot;acc:p26010]	0.00001	0.00001	1
	Subtracted			0	0	0
2952	Divided	ACVRL1	serine/threonine-protein kinase receptor r3 precursor (ec 2.7.1.37) (skr3) (activin receptor-like kinase 1) (alk-1) (tgf-b superfamily receptor type i) (tsr-i). [swissprot;acc:p37023]	0.00001	0.00001	1
	Subtracted			0	0	0
2953	Divided	GLIPR1	glioma pathogenesis-related protein (glipr) (rtvp-1 protein). [swissprot;acc:p48060]	0.00001	0.00001	1
	Subtracted			0	0	0
2954	Divided	NDUFA9	nadh-ubiquinone oxidoreductase 39 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-39kd) (ci-39kd). [swissprot;acc:q16795]	0.00001	0.00001	1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.