MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 5808 to 5857 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	network_comparison	green
2904	PTS	6-pyruvoyl tetrahydrobiopterin synthase (ec 4.2.3.12) (ptps) (ptp synthase). [swissprot;acc:q03393]	Subtracted	0	0	0
2905	ITGB1	integrin beta-1 precursor (fibronectin receptor beta subunit) (cd29 antigen) (integrin vla-4 beta subunit). [swissprot;acc:p05556]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2906	TAOK2	thousand and one amino acid protein kinase. [refseq;acc:nm_004783]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2907	ALDOA	fructose-bisphosphate aldolase a (ec 4.1.2.13) (muscle-type aldolase) (lung cancer antigen ny-lu-1). [swissprot;acc:p04075]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2908	CHEK1	serine/threonine-protein kinase chk1 (ec 2.7.1.-). [swissprot;acc:o14757]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2909	NKX6-2	nk6 transcription factor related, locus 2; nk homeobox family 6, b; glial and testis-specific homeobox protein; homeobox 6b. [refseq;acc:nm_177400]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2910	no value	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2911	COMMD3	bup protein. [refseq;acc:nm_012071]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2912	INPP5E	inositol polyphosphate-5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type iv; phosphatidylinositol (4,5) bisphosphate 5-phosphatase. [refseq;acc:nm_019892]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2913	AUH	au rna-binding protein/enoyl-coenzyme a hydratase precursor; au rna-binding protein/enoyl-coenzyme a hydratase; 3-methylglutaconyl-coa hydratase; mga type i. [refseq;acc:nm_001698]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2914	LACTB2	lactamase, beta 2. [refseq;acc:nm_016027]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2915	SLC25A37	mitochondrial solute carrier protein. [refseq;acc:nm_016612]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2916	PRPS1L1	ribose-phosphate pyrophosphokinase i (ec 2.7.6.1) (phosphoribosyl pyrophosphate synthetase i) (ppribp) (prs-i). [swissprot;acc:p09329]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2917	CCT6A	t-complex protein 1, zeta subunit (tcp-1-zeta) (cct-zeta) (cct-zeta-1) (tcp20) (htr3). [swissprot;acc:p40227]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2918	GBAS	nipsnap2 protein (glioblastoma amplified sequence). [swissprot;acc:o75323]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2919	GLRA1	glycine receptor alpha-1 chain precursor (glycine receptor 48 kda subunit) (strychnine binding subunit). [swissprot;acc:p23415]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2920	GLRA3	glycine receptor alpha-3 chain precursor. [swissprot;acc:o75311]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2921	EAF2	ell-associated factor 2; uncharacterized bone marrow protein bm040; testosterone regulated apoptosis inducer and tumor suppressor. [refseq;acc:nm_018456]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2922	ALDH1L1	10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2923	TMEM4	transmembrane protein 4. [refseq;acc:nm_014255]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2924	RQCD1	rcd1 required for cell differentiation1 homolog; protein involved in sexual development; rcd1 (required for cell differentiation, s.pombe) homolog 1. [refseq;acc:nm_005444]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2925	RALB	ras-related protein ral-b. [swissprot;acc:p11234]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2926	DUSP11	dual specificity protein phosphatase 11 (ec 3.1.3.48) (rna/rnp complex-intereracting phosphatase) (phosphatase that interacts with rna/rnp complex 1). [swissprot;acc:o75319]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2927	CIAO1	wd-repeat containing protein ciao 1. [swissprot;acc:o76071]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2928	no value	calmodulin. [swissprot;acc:p02593]	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
2929	LYST	lysosomal trafficking regulator (beige homolog). [swissprot;acc:q99698]	Divided	0.00001	1	0.00001

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.