MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 580 to 629 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
290	RRM2	ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350]	Divided	231.969	210.064	1.10428
291	AK2	adenylate kinase isoenzyme 2, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p54819]	Subtracted	241.509	264.163	22.654
	NFYB	nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208]	Divided	251.679	228.037	1.10368
292	HNRPM	heterogeneous nuclear ribonucleoprotein m (hnrnp m). [swissprot;acc:p52272]	Subtracted	234.146	256.627	22.481
	RPS15A	40s ribosomal protein s15a. [swissprot;acc:p39027]	Divided	241.411	266.414	1.10357
293	no value	60s ribosomal protein l23 (l17). [swissprot;acc:p23131]		240.782	265.717	1.10356
	HS3ST6	c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]	Subtracted	219.421	196.978	22.443
294	BCCIP	brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567]	Divided	240.782	265.717	1.10356
	HS3ST3A1	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	Subtracted	219.421	196.978	22.443
295	HS3ST3B1	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]
	SCYE1	multisynthetase complex auxiliary component p43 [contains: endothelial-monocyte activating polypeptide ii (emap-ii) (small inducible cytokine subfamily e member 1)]. [swissprot;acc:q12904]	Divided	223.273	202.423	1.103
296	HS3ST2	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	Subtracted	219.421	196.978	22.443
	MRPL4	mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	Divided	241.282	266.12	1.10294
297	no value	60s ribosomal protein l7. [swissprot;acc:p18124]		235.727	259.984	1.1029
	DCPS	mrna decapping enzyme; histidine triad protein member 5; heat shock-like protein 1. [refseq;acc:nm_014026]	Subtracted	219.421	196.978	22.443
298	CAPN2	calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655]	Divided	268.632	243.588	1.10281
	E2F1	transcription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1). [swissprot;acc:q01094]	Subtracted	266.421	244.236	22.185
299	CAPN1	calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384]	Divided	268.635	243.592	1.10281
	E2F2	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	Subtracted	266.421	244.236	22.185
300	DDX56	probable atp-dependent 61 kda nucleolar rna helicase (dead-box protein 21). [swissprot;acc:q9ny93]		257.017	234.945	22.072
	PITRM1	metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889]	Divided	150.959	166.351	1.10196
301	ALG1	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]		150.982	166.372	1.10193
	MAGED4	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Subtracted	88.2482	110.265	22.0168
302	MAGEE2	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]
	RPL26	60s ribosomal protein l26. [swissprot;acc:q02877]	Divided	242.326	267.008	1.10185
303	no value	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Subtracted	88.2482	110.265	22.0168
	RPL35	60s ribosomal protein l35. [swissprot;acc:p42766]	Divided	242.333	266.999	1.10179
304	no value	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]		242.339	266.986	1.1017
	MAGEA11	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Subtracted	88.2482	110.265	22.0168
305	MAGEA2B	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]
	MRPL2	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	Divided	242.339	266.986	1.1017
306	no value	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]		242.153	266.673	1.10126
		hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Subtracted	88.2482	110.265	22.0168
307	MAGEA6	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]
	SRR	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	Divided	242.153	266.673	1.10126
308	NDN	necdin. [swissprot;acc:q99608]	Subtracted	88.2482	110.265	22.0168
	RPL34	60s ribosomal protein l34. [swissprot;acc:p49207]	Divided	242.153	266.673	1.10126
309	MAGED1	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Subtracted	88.2482	110.265	22.0168
	SEC61A2	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]	Divided	242.153	266.673	1.10126
310	MAGEF1	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Subtracted	88.2482	110.265	22.0168
	SEC61A1	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]	Divided	242.153	266.673	1.10126
311	EIF1B	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]		242.627	267.151	1.10108
	MAGEB6B	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Subtracted	88.2482	110.265	22.0168
312	no value	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]
	RPL3L	60s ribosomal protein l3-like. [swissprot;acc:q92901]	Divided	242.195	266.663	1.10103
313	MAGEA9	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Subtracted	88.2482	110.265	22.0168
	RRM2B	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	Divided	232.473	211.207	1.10069
314	MAGEA8	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Subtracted	88.2482	110.265	22.0168
	METAP1	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]	Divided	244.126	268.604	1.10027
315	MAGEC1	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Subtracted	88.2482	110.265	22.0168

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.