MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 580 to 629 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Value Type	red	green	network_comparison
145	KCNIP4	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	Ranked	265.639	319.546	1.20293
146	KCNIP2	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]		265.632	319.531	1.20291
	PRPF40B	huntingtin interacting protein c. [refseq;acc:nm_012272]	Rooted	55.0737	66.0298	1.19894
	RRAGA	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	Squared	103496	146848	1.41888
	STAMBPL1	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	Measured	11068	8508.5	1.30082
147	no value	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Ranked	50.7983	42.3003	1.2009
	CHMP2A	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	Measured	11068	8508.5	1.30082
	FOXP4	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	Rooted	42.0574	50.4237	1.19893
	RRAGC	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	Squared	103496	146848	1.41888
148	FOXP1	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	Rooted	42.0577	50.424	1.19892
	RRAGB	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	Squared	103496	146848	1.41888
	STAMBP	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	Measured	11068	8508.5	1.30082
	UNC84A	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	Ranked	296.677	247.559	1.19841
149	no value	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]		142	170	1.19718
	ANLN	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	Squared	103496	146848	1.41888
	FOXP3	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	Rooted	42.0684	50.4323	1.19882
	VPS24	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	Measured	11068	8508.5	1.30082
150	CHMP4A	protein hspc134 (protein cda04). [swissprot;acc:q9by43]
	CLP1	pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989]	Squared	121200	85473.4	1.41799
	MYO5B	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Ranked	55	46	1.19565
	PPP2CA	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	Rooted	63.5827	53.0856	1.19774
151	CHRAC1	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]		38.8223	46.4975	1.1977
	DNASE2B	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Squared	250303	354894	1.41786
	MYO5C	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	Ranked	55	46	1.19565
	SH2D3C	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	Measured	4578.09	5939.91	1.29746
152	no value	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	Ranked	55	46	1.19565
	LUC7L2	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	Rooted	55.2859	65.9288	1.19251
	MAGED4	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Measured	23693.7	18263	1.29736
	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Squared	90226	126939	1.4069
153	no value	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]		70011	49783	1.40632
	LUC7L	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	Rooted	55.297	65.9236	1.19217
	MAGEE2	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Measured	23693.7	18263	1.29736
	RBM15B	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	Ranked	249.663	298.263	1.19466
154	no value	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Measured	23693.7	18263	1.29736
	CCT3	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	Squared	42788.3	60162.6	1.40605
	EIF5	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	Rooted	43.5479	51.5473	1.18369
	RGS19	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	Ranked	249.663	298.263	1.19466
155	CSTF2	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	Squared	126408	89940.5	1.40546
	MAGEA11	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Measured	23693.7	18263	1.29736
	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Ranked	249.663	298.263	1.19466
	SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Rooted	55.7423	65.6839	1.17835
156	MAGEA2B	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Measured	23693.7	18263	1.29736
	RGS20	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	Ranked	249.663	298.263	1.19466
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]	Squared	89578.7	125883	1.40528
	SH2D3C	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	Rooted	56.3447	66.124	1.17356
157	no value	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Measured	23693.7	18263	1.29736
	BRP44	brain protein 44. [swissprot;acc:o95563]	Squared	89182.8	125229	1.40418
	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	Rooted	52.7582	61.9123	1.17351
	LBX1	transcription factor lbx1. [swissprot;acc:p52954]	Ranked	249.663	298.263	1.19466
158	BCAR3	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	Rooted	56.3507	66.1252	1.17346

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.