MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 580 to 629 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Value Type	red	network_comparison	green
145	KCNIP4	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	Ranked	265.639	1.20293	319.546
146	KCNIP2	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]		265.632	1.20291	319.531
	PRPF40B	huntingtin interacting protein c. [refseq;acc:nm_012272]	Rooted	55.0737	1.19894	66.0298
	RRAGA	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	Squared	103496	1.41888	146848
	STAMBPL1	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	Measured	11068	1.30082	8508.5
147	no value	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Ranked	50.7983	1.2009	42.3003
	CHMP2A	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	Measured	11068	1.30082	8508.5
	FOXP4	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	Rooted	42.0574	1.19893	50.4237
	RRAGC	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	Squared	103496	1.41888	146848
148	FOXP1	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	Rooted	42.0577	1.19892	50.424
	RRAGB	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	Squared	103496	1.41888	146848
	STAMBP	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	Measured	11068	1.30082	8508.5
	UNC84A	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	Ranked	296.677	1.19841	247.559
149	no value	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]		142	1.19718	170
	ANLN	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	Squared	103496	1.41888	146848
	FOXP3	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	Rooted	42.0684	1.19882	50.4323
	VPS24	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	Measured	11068	1.30082	8508.5
150	CHMP4A	protein hspc134 (protein cda04). [swissprot;acc:q9by43]
	CLP1	pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989]	Squared	121200	1.41799	85473.4
	MYO5B	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Ranked	55	1.19565	46
	PPP2CA	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	Rooted	63.5827	1.19774	53.0856
151	CHRAC1	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]		38.8223	1.1977	46.4975
	DNASE2B	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Squared	250303	1.41786	354894
	MYO5C	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	Ranked	55	1.19565	46
	SH2D3C	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	Measured	4578.09	1.29746	5939.91
152	no value	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	Ranked	55	1.19565	46
	LUC7L2	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	Rooted	55.2859	1.19251	65.9288
	MAGED4	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Measured	23693.7	1.29736	18263
	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Squared	90226	1.4069	126939
153	no value	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]		70011	1.40632	49783
	LUC7L	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	Rooted	55.297	1.19217	65.9236
	MAGEE2	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Measured	23693.7	1.29736	18263
	RBM15B	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	Ranked	249.663	1.19466	298.263
154	no value	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Measured	23693.7	1.29736	18263
	CCT3	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	Squared	42788.3	1.40605	60162.6
	EIF5	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	Rooted	43.5479	1.18369	51.5473
	RGS19	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	Ranked	249.663	1.19466	298.263
155	CSTF2	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	Squared	126408	1.40546	89940.5
	MAGEA11	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Measured	23693.7	1.29736	18263
	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Ranked	249.663	1.19466	298.263
	SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Rooted	55.7423	1.17835	65.6839
156	MAGEA2B	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Measured	23693.7	1.29736	18263
	RGS20	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	Ranked	249.663	1.19466	298.263
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]	Squared	89578.7	1.40528	125883
	SH2D3C	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	Rooted	56.3447	1.17356	66.124
157	no value	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Measured	23693.7	1.29736	18263
	BRP44	brain protein 44. [swissprot;acc:o95563]	Squared	89182.8	1.40418	125229
	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	Rooted	52.7582	1.17351	61.9123
	LBX1	transcription factor lbx1. [swissprot;acc:p52954]	Ranked	249.663	1.19466	298.263
158	BCAR3	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	Rooted	56.3507	1.17346	66.1252

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.