MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 575 to 624 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
alcohol dehydrogenase class iii chi chain (ec 1.1.1.1) (glutathione- dependent formaldehyde dehydrogenase) (ec 1.2.1.1) (fdh). [swissprot;acc:p11766]	2504	no value	Low confidence	194.402	190.933	1.01817
alcohol dehydrogenase [nadp+] (ec 1.1.1.2) (aldehyde reductase) (aldo- keto reductase family 1 member a1). [swissprot;acc:p14550]	1910	AKR1A1		201.288	197.387	1.01976
aldehyde dehydrogenase 7 (ec 1.2.1.5). [swissprot;acc:p43353]	648	ALDH3B1		210.325	216.359	1.02869
	3222		High confidence	0.00001	0.00001	1
aldehyde dehydrogenase 8 (ec 1.2.1.5). [swissprot;acc:p48448]	845	ALDH3B2	Low confidence	209.59	215.023	1.02592
	2992		High confidence	0.00001	0.00001	1
aldehyde dehydrogenase family 7 member a1 (ec 1.2.1.3) (antiquitin 1). [swissprot;acc:p49419]	3480	ALDH7A1	Low confidence	201.442	198.465	1.015
aldehyde dehydrogenase x, mitochondrial precursor (ec 1.2.1.3) (aldh class 2). [swissprot;acc:p30837]	1484	ALDH1B1		205.089	209.494	1.02148
aldehyde dehydrogenase, dimeric nadp-preferring (ec 1.2.1.5) (aldh class 3) (aldhiii). [swissprot;acc:p30838]	3085	ALDH3A1		198.745	195.513	1.01653
aldehyde oxidase (ec 1.2.3.1). [swissprot;acc:q06278]	1600	AOX1		201.174	197.046	1.02095
	2960		High confidence	0.00001	0.00001	1
aldo-keto reductase family 1 member b10 (ec 1.1.1.-) (aldose reductase-like) (arl-1) (small intestine reductase) (si reductase) (aldose reductase-related protein) (arp) (harp). [swissprot;acc:o60218]	2464	no value	Low confidence	201.277	197.66	1.0183
aldo-keto reductase family 1 member c1 (ec 1.1.1.-) (trans-1,2- dihydrobenzene-1,2-diol dehydrogenase) (ec 1.3.1.20) (high-affinity hepatic bile acid-binding protein) (hbab) (chlordecone reductase homolog hakrc) (dihydrodiol dehydrogenase 2) (dd2) (20 alpha- hydroxysteroid dehydrogenase). [swissprot;acc:q04828]	1897	AKR1C1		201.286	197.384	1.01977
aldo-keto reductase family 1 member c2 (ec 1.1.1.-) (trans-1,2- dihydrobenzene-1,2-diol dehydrogenase) (ec 1.3.1.20) (chlordecone reductase homolog hakrd) (dihydrodiol dehydrogenase/bile acid-binding protein) (dd/babp) (dihydrodiol dehydrogenase 2) (dd2). [swissprot;acc:p52895]	1900	AKR1C2
aldo-keto reductase family 1 member c4 (ec 1.1.1.-) (chlordecone reductase) (ec 1.1.1.225) (cdr) (3-alpha-hydroxysteroid dehydrogenase) (ec 1.1.1.50) (3-alpha-hsd) (dihydrodiol dehydrogenase 4) (dd4) (hakra). [swissprot;acc:p17516]	1903	no value
aldo-keto reductase loopadr; aldo-keto reductase related protein. [refseq;acc:nm_031436]	1899	AKR1CL2
aldose reductase (ec 1.1.1.21) (ar) (aldehyde reductase). [swissprot;acc:p15121]	2553	AKR1B1		201.278	197.708	1.01806
alkaline phytoceramidase (ec 3.5.1.-) (aphc) (alkaline ceramidase) (alkaline dihydroceramidase sb89). [swissprot;acc:q9nun7]	2555	PHCA		200.327	196.774
all1 fused gene from 5q31. [refseq;acc:nm_014423]	373	AFF4		219.598	211.722	1.0372
alpha 2 globin. [refseq;acc:nm_000517]	511	no value		205.157	198.715	1.03242
alpha adducin (erythrocyte adducin alpha subunit). [swissprot;acc:p35611]	1628	ADD1		205.76	201.569	1.02079
	1965		High confidence	224.432	222.258	1.00978
alpha crystallin a chain. [swissprot;acc:p02489]	199	CRYAA	Low confidence	219.589	208.895	1.05119
	2875		High confidence	0.00001	0.00001	1
alpha crystallin b chain (alpha(b)-crystallin) (rosenthal fiber component). [swissprot;acc:p02511]	200	CRYAB	Low confidence	219.543	208.868	1.05111
	3082		High confidence	0.00001	0.00001	1
alpha crystallin c chain (small stress protein-like protein hsp22) (e2ig1) (protein kinase h11). [swissprot;acc:q9ujy1]	1450	HSPB8		221.804	226.194	1.01979
	4001		Low confidence	205.873	203.49	1.01171
alpha enolase (ec 4.2.1.11) (2-phospho-d-glycerate hydro-lyase) (non- neural enolase) (nne) (enolase 1) (phosphopyruvate hydratase). [swissprot;acc:p06733]	2363	ENO1	High confidence	207.186	208.046	1.00415
	4639		Low confidence	202.002	200.683	1.00657
alpha glucosidase ii alpha subunit; likely ortholog of mouse g2an alpha glucosidase 2, alpha neutral subunit. [refseq;acc:nm_014610]	2536	GANAB		198.976	195.437	1.01811
alpha-(1,6)-fucosyltransferase (ec 2.4.1.68) (glycoprotein 6-alpha-l- fucosyltransferase) (gdp-fucose--glycoprotein fucosyltransferase) (gdp-l-fuc:n-acetyl-beta-d-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6fuct) (fucosyltransferase 8). [swissprot;acc:q9byc5]	1726	FUT8	High confidence	217.676	220.53	1.01311
	3767		Low confidence	200.573	197.917	1.01342
alpha-1 catenin (cadherin-associated protein) (alpha e-catenin). [swissprot;acc:p35221]	3167	CTNNA1		202.715	199.486	1.01619
alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]	1189	no value	High confidence	209.649	204.406	1.02565
	1638		Low confidence	203.742	199.603	1.02074
alpha-1-syntrophin (59 kda dystrophin-associated protein a1, acidic component 1) (pro-tgf-alpha cytoplasmic domain-interacting protein 1) (tacip1) (syntrophin 1). [swissprot;acc:q13424]	2587	SNTA1	High confidence	213.422	213.75	1.00154
	3284		Low confidence	202.385	199.258	1.01569
alpha-2 catenin (alpha-catenin related protein) (alpha n-catenin). [swissprot;acc:p26232]	3165	CTNNA2		202.715	199.486	1.01619
alpha-2-macroglobulin receptor-associated protein precursor (alpha-2-mrap) (low density lipoprotein receptor-related protein- associated protein 1) (rap). [swissprot;acc:p30533]	1332	LRPAP1		203.765	199.349	1.02215
alpha-actinin 1 (alpha-actinin cytoskeletal isoform) (non-muscle alpha-actinin 1) (f-actin cross linking protein). [swissprot;acc:p12814]	1806	ACTN1	High confidence	217.009	214.482	1.01178
	4748		Low confidence	204.297	203.223	1.00528
alpha-actinin 2 (alpha actinin skeletal muscle isoform 2) (f-actin cross linking protein). [swissprot;acc:p35609]	1799	ACTN2	High confidence	217.016	214.481	1.01182
	4762		Low confidence	204.331	203.321	1.00497
alpha-actinin 4 (non-muscle alpha-actinin 4) (f-actin cross linking protein). [swissprot;acc:o43707]	1805	ACTN4	High confidence	217.008	214.482	1.01178
	4751		Low confidence	204.3	203.243	1.0052
alpha-aminoadipate aminotransferase; l-kynurenine/alpha-aminoadipate aminotransferase; kynurenine aminotransferase ii. [refseq;acc:nm_016228]	988	AADAT		186.556	182.079	1.02459
alpha-amylase, salivary precursor (ec 3.2.1.1) (1,4-alpha-d-glucan glucanohydrolase). [swissprot;acc:p04745]	282	AMY1C		219.742	210.498	1.04391
	3914	no value		207.449	204.872	1.01258
alpha-centractin (centractin) (centrosome-associated actin homolog) (actin-rpv) (arp1). [swissprot;acc:p42024]	1509	ACTR1A	High confidence	225.148	221.177	1.01795

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.