MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Network Comparison Type	Rank	Gene	Hugo	description	Value Type	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 575 to 624 of 2060 in total

Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Filtered  : 1
network_comparison  : 0
red  : 0
green  : 0

Rank	Hugo	description	Value Type
2899	SPARCL1	sparc-like protein 1 precursor (high endothelial venule protein) (hevin) (mast 9). [swissprot;acc:q14515]	Squared
			Rooted
2900	SCHIP1	schwannomin interacting protein 1. [refseq;acc:nm_014575]	Measured
			Ranked
			Squared
			Rooted
2901	CSNK1G3	casein kinase i, gamma 3 isoform (ec 2.7.1.-) (cki-gamma 3). [swissprot;acc:q9y6m4]	Measured
			Ranked
			Squared
			Rooted
2902	UBE3B	ubiquitin protein ligase. [refseq;acc:nm_130466]	Measured
			Ranked
			Squared
			Rooted
2903	SEC24D	protein transport protein sec24d (sec24-related protein d). [swissprot;acc:o94855]	Measured
			Ranked
			Squared
			Rooted
2904	PTS	6-pyruvoyl tetrahydrobiopterin synthase (ec 4.2.3.12) (ptps) (ptp synthase). [swissprot;acc:q03393]	Measured
			Ranked
			Squared
			Rooted
2905	ITGB1	integrin beta-1 precursor (fibronectin receptor beta subunit) (cd29 antigen) (integrin vla-4 beta subunit). [swissprot;acc:p05556]	Measured
			Ranked
			Squared
			Rooted
2906	TAOK2	thousand and one amino acid protein kinase. [refseq;acc:nm_004783]	Measured
			Ranked
			Squared
			Rooted
2907	ALDOA	fructose-bisphosphate aldolase a (ec 4.1.2.13) (muscle-type aldolase) (lung cancer antigen ny-lu-1). [swissprot;acc:p04075]	Measured
			Ranked
			Squared
			Rooted
2908	CHEK1	serine/threonine-protein kinase chk1 (ec 2.7.1.-). [swissprot;acc:o14757]	Measured
			Ranked
			Squared
			Rooted
2909	NKX6-2	nk6 transcription factor related, locus 2; nk homeobox family 6, b; glial and testis-specific homeobox protein; homeobox 6b. [refseq;acc:nm_177400]	Measured
			Ranked
			Squared
			Rooted
2910	no value	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]	Measured
			Ranked
			Squared
			Rooted
2911	COMMD3	bup protein. [refseq;acc:nm_012071]	Measured
			Ranked
			Squared
			Rooted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.