MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 575 to 624 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
144	Squared	tumor suppressor p53-binding protein 2 (p53-binding protein 2) (53bp2) (bcl2-binding protein) (bbp). [swissprot;acc:q13625]	123324	86277.9	1.42938
	Rooted	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	55.6161	66.7332	1.19989
145	Measured	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	16771.5	12889.1	1.30122
	Ranked	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	265.639	319.546	1.20293
	Squared	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	310840	442993	1.42515
	Rooted	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	55.6161	66.7332	1.19989
146	Measured	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	11068	8508.5	1.30082
	Ranked	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	265.632	319.531	1.20291
	Squared	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	103496	146848	1.41888
	Rooted	huntingtin interacting protein c. [refseq;acc:nm_012272]	55.0737	66.0298	1.19894
147	Measured	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	11068	8508.5	1.30082
	Ranked	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	50.7983	42.3003	1.2009
	Squared	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	103496	146848	1.41888
	Rooted	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	42.0574	50.4237	1.19893
148	Measured	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	11068	8508.5	1.30082
	Ranked	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	296.677	247.559	1.19841
	Squared	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	103496	146848	1.41888
	Rooted	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	42.0577	50.424	1.19892
149	Measured	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	11068	8508.5	1.30082
	Ranked	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	142	170	1.19718
	Squared	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	103496	146848	1.41888
	Rooted	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	42.0684	50.4323	1.19882
150	Measured	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	11068	8508.5	1.30082
	Ranked	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	55	46	1.19565
	Squared	pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989]	121200	85473.4	1.41799
	Rooted	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	63.5827	53.0856	1.19774
151	Measured	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	4578.09	5939.91	1.29746
	Ranked	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	55	46	1.19565
	Squared	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	250303	354894	1.41786
	Rooted	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	38.8223	46.4975	1.1977
152	Measured	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	23693.7	18263	1.29736
	Ranked	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	55	46	1.19565
	Squared	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	90226	126939	1.4069
	Rooted	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	55.2859	65.9288	1.19251
153	Measured	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	23693.7	18263	1.29736
	Ranked	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	249.663	298.263	1.19466
	Squared	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	70011	49783	1.40632
	Rooted	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	55.297	65.9236	1.19217
154	Measured	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	23693.7	18263	1.29736
	Ranked	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	249.663	298.263	1.19466
	Squared	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	42788.3	60162.6	1.40605
	Rooted	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	43.5479	51.5473	1.18369
155	Measured	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	23693.7	18263	1.29736
	Ranked	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	249.663	298.263	1.19466
	Squared	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	126408	89940.5	1.40546
	Rooted	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	55.7423	65.6839	1.17835
156	Measured	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	23693.7	18263	1.29736
	Ranked	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	249.663	298.263	1.19466
	Squared	septin 10 isoform 1. [refseq;acc:nm_144710]	89578.7	125883	1.40528
	Rooted	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	56.3447	66.124	1.17356

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.