MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	Hugo	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 570 to 619 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
143	FBXW7	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	Subtracted	Low confidence	211.056	198.732	12.324
	PSEN2	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Divided				1.06201
	SF4	splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164]	Subtracted	High confidence	240.133	211.382	28.751
144	CSRP1	cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291]			239.35	267.915	28.565
	FBXW7	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	Divided	Low confidence	211.056	198.732	1.06201
	KCNIP1	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]		High confidence	265.686	319.651	1.20312
	PSEN1	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	Subtracted	Low confidence	211.056	198.732	12.324
145	KCNIP4	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	Divided	High confidence	265.639	319.546	1.20293
	PSEN1	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]		Low confidence	211.056	198.732	1.06201
	SENP8	sentrin-specific protease 8 (ec 3.4.22.-) (sentrin/sumo-specific protease senp8) (cysteine protease fksg8). [swissprot;acc:q96ld8]	Subtracted		210.579	198.33	12.249
	SHCBP1	likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745]		High confidence	239.336	267.881	28.545
146	CSRP2	smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527]				267.879	28.543
	KCNIP2	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	Divided		265.632	319.531	1.20291
	NDUFS4	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]		Low confidence	226.892	213.661	1.06193
	NEDD8	ubiquitin-like protein nedd8. [swissprot;acc:q15843]	Subtracted		210.579	198.33	12.249
147	no value	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Divided	High confidence	50.7983	42.3003	1.2009
	ARHGEF6	rho guanine nucleotide exchange factor 6 (pak-interacting exchange factor alpha) (alpha-pix) (cool-2). [swissprot;acc:q15052]		Low confidence	219.273	206.507	1.06182
	CAPN1	calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384]	Subtracted		222.508	210.345	12.163
	CSRP3	lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461]		High confidence	239.32	267.842	28.522
148	CAPN2	calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655]		Low confidence	222.502	210.342	12.16
	FLNB	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]		High confidence	226.582	198.444	28.138
	SENP8	sentrin-specific protease 8 (ec 3.4.22.-) (sentrin/sumo-specific protease senp8) (cysteine protease fksg8). [swissprot;acc:q96ld8]	Divided	Low confidence	210.579	198.33	1.06176
	UNC84A	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]		High confidence	296.677	247.559	1.19841
149	no value	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]			142	170	1.19718
	HMG20B	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Subtracted	Low confidence	202.996	190.854	12.142
	NEDD8	ubiquitin-like protein nedd8. [swissprot;acc:q15843]	Divided		210.579	198.33	1.06176
	REV1	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	Subtracted	High confidence	226.582	198.444	28.138
150	CTSL2	cathepsin l2 precursor (ec 3.4.22.43) (cathepsin v) (cathepsin u). [swissprot;acc:o60911]		Low confidence	211.818	199.734	12.084
	MYO5B	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Divided	High confidence	55	46	1.19565
	PLK1	serine/threonine-protein kinase plk (ec 2.7.1.-) (plk-1) (serine- threonine protein kinase 13) (stpk13). [swissprot;acc:p53350]		Low confidence	206.516	194.554	1.06148
	PRMT1	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	Subtracted	High confidence	226.582	198.444	28.138
151	CTSZ	cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2]	Divided	Low confidence	206.516	194.554	1.06148
	LASS2	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	Subtracted		191.688	179.639	12.049
	MYO5C	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	Divided	High confidence	55	46	1.19565
	PRMT8	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	Subtracted		226.582	198.444	28.138
152	no value	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	Divided		55	46	1.19565
	CTSL1	cathepsin l precursor (ec 3.4.22.15) (major excreted protein) (mep). [swissprot;acc:p07711]	Subtracted	Low confidence	211.808	199.761	12.047
	HMG20A	high-mobility group 20a. [refseq;acc:nm_018200]	Divided		202.934	191.187	1.06144
	SNRP70	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	Subtracted	High confidence	226.582	198.444	28.138
153	no value	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]
	PLK1	serine/threonine-protein kinase plk (ec 2.7.1.-) (plk-1) (serine- threonine protein kinase 13) (stpk13). [swissprot;acc:p53350]		Low confidence	206.516	194.554	11.962
	RAB11FIP4	rab11-family interacting protein 4. [refseq;acc:nm_032932]	Divided		183.27	172.702	1.06119
	RBM15B	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]		High confidence	249.663	298.263	1.19466
154	CTSZ	cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2]	Subtracted	Low confidence	206.516	194.554	11.962
	MSI2	musashi 2 isoform a. [refseq;acc:nm_138962]		High confidence	227.491	199.458	28.033
	RAB11FIP3	eferin. [swissprot;acc:o75154]	Divided	Low confidence	183.27	172.702	1.06119
	RGS19	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]		High confidence	249.663	298.263	1.19466
155	CTSL2	cathepsin l2 precursor (ec 3.4.22.43) (cathepsin v) (cathepsin u). [swissprot;acc:o60911]		Low confidence	211.818	199.734	1.0605
	MSI1	musashi 1. [refseq;acc:nm_002442]	Subtracted	High confidence	227.491	199.458	28.033
	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Divided		249.663	298.263	1.19466

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.