MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 562 to 611 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
angiomotin. [refseq;acc:nm_133265]	2585	AMOT	Subtracted	213.422	213.75	0.328
anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	143	ANLN	Divided	59	49	1.20408
	773		Subtracted			10
ankyrin 2 (brain ankyrin) (ankyrin b) (ankyrin, nonerythroid). [swissprot;acc:q01484]	2516	ANK2		215.835	216.341	0.506
	2519		Divided			1.00234
ankyrin 3 (ank-3) (ankyrin g). [swissprot;acc:q12955]	2515	ANK3	Subtracted			0.506
	2518		Divided			1.00234
ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	793	ANKRA2	Subtracted	212.386	221.785	9.399
	805		Divided			1.04425
annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	1051	ANXA11	Subtracted	219.673	213.378	6.295
	1088		Divided			1.0295
annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	1053	ANXA7	Subtracted	219.655	213.385	6.27
	1094		Divided			1.02938
antithrombin-iii precursor (atiii) (pro0309). [swissprot;acc:p01008]	2406	SERPINC1	Subtracted	218.2	218.984	0.784
	2418		Divided			1.00359
apg3p; pc3-96 protein. [refseq;acc:nm_022488]	169	ATG3		82.5916	98.0548	1.18722
	489		Subtracted			15.4632
apical-like protein (apxl protein). [swissprot;acc:q13796]	346	SHROOM2		231.492	211.136	20.356
	362		Divided			1.09641
apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	211	no value	Subtracted	237.302	212.41	24.892
	248		Divided			1.11719
apolipoprotein a-i binding protein; apoa-i binding protein. [refseq;acc:nm_144772]	1606	APOA1BP		207.916	204.662	1.0159
	1609		Subtracted			3.254
apolipoprotein b-100 precursor (apo b-100) [contains: apolipoprotein b-48 (apo b-48)]. [swissprot;acc:p04114]	2128	APOB		217.871	219.366	1.495
	2151		Divided			1.00686
apopain precursor (ec 3.4.22.-) (cysteine protease cpp32) (yama protein) (cpp-32) (caspase-3) (casp-3) (srebp cleavage activity 1) (sca-1). [swissprot;acc:p42574]	1166	CASP3	Subtracted	233.942	228.46	5.482
	1293		Divided			1.024
apoptosis antagonizing transcription factor. [refseq;acc:nm_012138]	929	AATF	Subtracted	243.045	235.422	7.623
	1014		Divided			1.03238
apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]	1094	API5	Subtracted	218.484	212.675	5.809
	1132		Divided			1.02731
apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	1083	no value	Subtracted	217.99	212.123	5.867
	1111		Divided			1.02766
apoptosis-inducing factor (aif)-homologous mitochondrion-associated inducer of death; p53-responsive gene 3. [refseq;acc:nm_032797]	2418	AIFM2	Subtracted	210.205	209.454	0.751
	2421		Divided			1.00359
apurinic/apyrimidinic endonuclease 2; apurinic/apyrimidinic endonuclease-like 2; apex nuclease-like 2. [refseq;acc:nm_014481]	2523	APEX2	Subtracted	216.264	215.787	0.477
	2531		Divided			1.00221
aquaporin 4 (wch4) (mercurial-insensitive water channel) (miwc). [swissprot;acc:p55087]	2688	AQP4	Subtracted	188.191	188.046	0.145
	2690		Divided			1.00077
aquaporin 5. [swissprot;acc:p55064]		AQP5	Subtracted	188.192	188.048	0.144
	2692		Divided			1.00077
aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	2689	AQP2	Subtracted	188.193		0.145
	2691		Divided			1.00077
aquaporin-chip (water channel protein for red blood cells and kidney proximal tubule) (aquaporin 1) (aqp-1) (urine water channel). [swissprot;acc:p29972]	2694	AQP1		188.223	188.081	1.00075
			Subtracted			0.142
arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7]	1142	GIT1		216.729	222.334	5.605
	1184		Divided			1.02586
arf gtpase-activating protein git2 (g protein-coupled receptor kinase- interactor 2). [swissprot;acc:q14161]	1070	GIT2	Subtracted	216.78	222.782	6.002
	1110		Divided			1.02769
arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	944	SORBS2	Subtracted	212.51	205.191	7.319

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.