MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	Hugo	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 5591 to 5640 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
1398	EYA4	eyes absent homolog 4. [swissprot;acc:o95677]	Divided	High confidence	218.449	213.864	1.02144
	WDR26	wd repeat domain 26. [refseq;acc:nm_025160]	Subtracted		213.351	217.74	4.389
1399	BRUNOL4	bruno-like 4, rna binding protein; rna-binding protein brunol-5; cug-bp and etr-3 like factor 4. [refseq;acc:nm_020180]		Low confidence	202.785	198.472	4.313
	EYA2	eyes absent homolog 2. [swissprot;acc:o00167]	Divided	High confidence	218.417	213.848	1.02137
	MPP6	maguk p55 subfamily member 6 (veli-associated maguk 1) (vam-1). [swissprot;acc:q9nzw5]	Subtracted		228.469	232.855	4.386
	SPOP	speckle-type poz protein. [swissprot;acc:o43791]	Divided	Low confidence	201.397	197.08	1.0219
1400	ANXA11	annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]			203.717	199.354	1.02189
	ATF7	cyclic-amp-dependent transcription factor atf-7 (activating transcription factor 7) (transcription factor atf-a). [swissprot;acc:p17544]		High confidence	218.667	214.118	1.02125
	CAPZA3	f-actin capping protein alpha-3 subunit (capz alpha-3) (germ cell- specific protein 3). [swissprot;acc:q96kx2]	Subtracted	Low confidence	201.426	197.115	4.311
	PROSC	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]		High confidence	170.28	165.898	4.382
1401	ATF2	cyclic-amp-dependent transcription factor atf-2 (activating transcription factor 2) (camp response element binding protein cre- bp1) (hb16). [swissprot;acc:p15336]	Divided		218.657	214.11	1.02124
	NFKBIA	nf-kappab inhibitor alpha (major histocompatibility complex enhancer- binding protein mad3) (i-kappa-b-alpha) (ikappabalpha) (ikb-alpha). [swissprot;acc:p25963]		Low confidence	202.066	197.737	1.02189
	NR6A1	orphan nuclear receptor nr6a1 (germ cell nuclear factor) (gcnf) (retinoid receptor-related testis specific receptor) (rtr). [swissprot;acc:q15406]	Subtracted	High confidence	212.833	208.456	4.377
	SYT14	synaptotagmin xiv. [refseq;acc:nm_153262]		Low confidence	203.719	199.408	4.311
1402	ARG2	arginase ii, mitochondrial precursor (ec 3.5.3.1) (non-hepatic arginase) (kidney-type arginase). [swissprot;acc:p78540]	Divided		201.12	196.811	1.02189
	MCC	colorectal mutant cancer protein (mcc protein). [swissprot;acc:p23508]		High confidence	209.682	205.329	1.0212
			Subtracted				4.353
	PDE9A	high-affinity cgmp-specific 3',5'-cyclic phosphodiesterase 9a (ec 3.1.4.17). [swissprot;acc:o76083]		Low confidence	187.917	183.608	4.309
1403	CAPZA3	f-actin capping protein alpha-3 subunit (capz alpha-3) (germ cell- specific protein 3). [swissprot;acc:q96kx2]	Divided		201.426	197.115	1.02187
	CPSF2	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	Subtracted	High confidence	110.2	114.552	4.352
	ECHS1	enoyl-coa hydratase, mitochondrial precursor (ec 4.2.1.17) (short chain enoyl-coa hydratase) (sceh) (enoyl-coa hydratase 1). [swissprot;acc:p30084]	Divided		184.656	180.823	1.0212
	KIAA0664	putative eukaryotic translation initiation factor 3 subunit (eif-3) (fragment). [swissprot;acc:o75153]	Subtracted	Low confidence	200.723	196.414	4.309
1404	ABCE1	atp-binding cassette sub-family e member 1 (rnase l inhibitor) (ribonuclease 4 inhibitor) (rns4i) (huhp68). [swissprot;acc:q96b10]	Divided		202.268	197.939	1.02187
	KRR1	hiv-1 rev binding protein 2; rev interacting protein. [refseq;acc:nm_007043]	Subtracted	High confidence	242.181	237.834	4.347
	SF3B4	splicing factor 3b subunit 4 (spliceosome associated protein 49) (sap 49) (sf3b50) (pre-mrna splicing factor sf3b 49 kda subunit). [swissprot;acc:q15427]	Divided		232.752	237.65	1.02104
	SLC36A1	solute carrier family 36 member 1; proton / amino acid symporter; lysosomal amino acid transporter 1. [refseq;acc:nm_078483]	Subtracted	Low confidence	187.917	183.608	4.309
1405	ARG2	arginase ii, mitochondrial precursor (ec 3.5.3.1) (non-hepatic arginase) (kidney-type arginase). [swissprot;acc:p78540]			201.12	196.811
	CYR61	cyr61 protein precursor (cysteine-rich, angiogenic inducer, 61) (insulin-like growth factor-binding protein 10) (gig1 protein). [swissprot;acc:o00622]	Divided		208.227	203.771	1.02187
	EIF3C	eukaryotic translation initiation factor 3 subunit 8 (eif3 p110) (eif3c). [swissprot;acc:q99613]		High confidence	245.532	240.483	1.021
	EVI5L	similar to ecotropic viral integration site 5; neuroblastoma stage 4s gene. [refseq;acc:nm_145245]	Subtracted		218.829	214.493	4.336
1406	AGPAT2	1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]		Low confidence	198.322	194.014	4.308
	EVI5	ecotropic viral integration site 5; neuroblastoma stage 4s gene. [refseq;acc:nm_005665]		High confidence	218.829	214.493	4.336
	MPPED2	fetal brain protein 239 (239fb). [swissprot;acc:q15777]	Divided	Low confidence	204.115	199.746	1.02187
	NR6A1	orphan nuclear receptor nr6a1 (germ cell nuclear factor) (gcnf) (retinoid receptor-related testis specific receptor) (rtr). [swissprot;acc:q15406]		High confidence	212.833	208.456	1.021
1407	F11R	junctional adhesion molecule 1 precursor (jam) (platelet adhesion molecule 1) (pam-1) (platelet f11 receptor). [swissprot;acc:q9y624]	Subtracted	Low confidence	200.065	195.758	4.307
	PYCR1	pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322]	Divided		197.603	193.375	1.02186
	WDFY1	wd repeat and fyve domain containing 1 isoform 1; phosphoinositide-binding protein sr1; wd40 and fyve domain containing 1. [refseq;acc:nm_020830]		High confidence	206.104	210.424	1.02096
			Subtracted				4.32
1408	no value	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]		Low confidence	198.342	194.038	4.304
	EARS2	glutamyl trna synthetase. [sptrembl;acc:o14563]	Divided		196.216	192.019	1.02186
	STIM1	stromal interaction molecule 1 precursor. [swissprot;acc:q13586]		High confidence	206.102	210.42	1.02095
			Subtracted				4.318
1409	ASNS	asparagine synthetase [glutamine-hydrolyzing] (ec 6.3.5.4) (glutamine- dependent asparagine synthetase) (ts11 cell cycle control protein). [swissprot;acc:p08243]		Low confidence	187.8	183.496	4.304
	MED30	trap/mediator complex component trap25. [refseq;acc:nm_080651]	Divided	High confidence	206.102	210.42	1.02095
			Subtracted				4.318
	NFIL3	nuclear factor, interleukin 3 regulated. [refseq;acc:nm_005384]	Divided	Low confidence	195.821	191.636	1.02184
1410	PAK4	serine/threonine-protein kinase pak 4 (ec 2.7.1.-) (p21-activated kinase 4) (pak-4). [swissprot;acc:o96013]	Subtracted	High confidence	206.102	210.42	4.318
	RAB13	ras-related protein rab-13. [swissprot;acc:p51153]		Low confidence	200.618	196.316	4.302
	RALGDS	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]	Divided		199.829	195.558	1.02184
	WDFY2	wd repeat- and fyve domain-containing protein 2; wd40 and fyve domain containing 2. [refseq;acc:nm_052950]		High confidence	206.1	210.417	1.02095

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.