MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Network Comparison Type	Hugo	Value Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 558 to 607 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
aflatoxin b1 aldehyde reductase 1 (ec 1.-.-.-) (afb1-ar 1) (aldoketoreductase 7). [swissprot;acc:o43488]	1586	AKR7A2	Low confidence	190.955	187.021	1.02104
	1969		High confidence	211.633	213.703	1.00978
aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154]	1584	AKR7A3	Low confidence	190.926	186.991	1.02104
	1958		High confidence	211.633	213.703	1.00978
aggrecan core protein precursor (cartilage-specific proteoglycan core protein) (cspcp) (chondroitin sulfate proteoglycan core protein 1). [swissprot;acc:p16112]	2638	ACAN	Low confidence	203.73	200.174	1.01776
ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170]	1157	AIP	High confidence	224.307	230.242	1.02646
	3718		Low confidence	200.599	197.9	1.01364
aladin (adracalin) (gl003). [swissprot;acc:q9nrg9]	4944	AAAS		205.2	204.964	1.00115
alanine aminotransferase (ec 2.6.1.2) (glutamic--pyruvic transaminase) (gpt) (glutamic--alanine transaminase). [swissprot;acc:p24298]	1531	GPT		195.485	191.412	1.02128
	2025		High confidence	189.987	191.668	1.00885
alanine aminotransferase 2; glutamic-pyruvate transaminase 2. [refseq;acc:nm_133443]	1514	GPT2	Low confidence	195.292	191.212	1.02134
	2030		High confidence	189.999	191.677	1.00883
alanine--glyoxylate aminotransferase 2, mitochondrial precursor (ec 2.6.1.44) (agt 2) (beta-alanine-pyruvate aminotransferase) (beta- alaat ii). [swissprot;acc:q9byv1]	3990	AGXT2	Low confidence	206.934	209.395	1.01189
alanine-glyoxylate aminotransferase 2-like 1. [refseq;acc:nm_031279]	3727	AGXT2L1		199.247	196.581	1.01356
alanyl-trna synthetase (ec 6.1.1.7) (alanine--trna ligase) (alars). [swissprot;acc:p49588]	633	AARS	High confidence	234.106	248.104	1.05979
	2688		Low confidence	201.799	198.308	1.0176
alcohol dehydrogenase class iii chi chain (ec 1.1.1.1) (glutathione- dependent formaldehyde dehydrogenase) (ec 1.2.1.1) (fdh). [swissprot;acc:p11766]	2428	no value	High confidence	192.871	193.555	1.00355
	2504		Low confidence	194.402	190.933	1.01817
alcohol dehydrogenase [nadp+] (ec 1.1.1.2) (aldehyde reductase) (aldo- keto reductase family 1 member a1). [swissprot;acc:p14550]	1910	AKR1A1		201.288	197.387	1.01976
aldehyde dehydrogenase 7 (ec 1.2.1.5). [swissprot;acc:p43353]	648	ALDH3B1		210.325	216.359	1.02869
	3222		High confidence	0.00001	0.00001	1
aldehyde dehydrogenase 8 (ec 1.2.1.5). [swissprot;acc:p48448]	845	ALDH3B2	Low confidence	209.59	215.023	1.02592
	2992		High confidence	0.00001	0.00001	1
aldehyde dehydrogenase family 7 member a1 (ec 1.2.1.3) (antiquitin 1). [swissprot;acc:p49419]	3480	ALDH7A1	Low confidence	201.442	198.465	1.015
aldehyde dehydrogenase x, mitochondrial precursor (ec 1.2.1.3) (aldh class 2). [swissprot;acc:p30837]	1484	ALDH1B1		205.089	209.494	1.02148
aldehyde dehydrogenase, dimeric nadp-preferring (ec 1.2.1.5) (aldh class 3) (aldhiii). [swissprot;acc:p30838]	3085	ALDH3A1		198.745	195.513	1.01653
aldehyde oxidase (ec 1.2.3.1). [swissprot;acc:q06278]	1600	AOX1		201.174	197.046	1.02095
	2960		High confidence	0.00001	0.00001	1
aldo-keto reductase family 1 member b10 (ec 1.1.1.-) (aldose reductase-like) (arl-1) (small intestine reductase) (si reductase) (aldose reductase-related protein) (arp) (harp). [swissprot;acc:o60218]	2464	no value	Low confidence	201.277	197.66	1.0183
aldo-keto reductase family 1 member c1 (ec 1.1.1.-) (trans-1,2- dihydrobenzene-1,2-diol dehydrogenase) (ec 1.3.1.20) (high-affinity hepatic bile acid-binding protein) (hbab) (chlordecone reductase homolog hakrc) (dihydrodiol dehydrogenase 2) (dd2) (20 alpha- hydroxysteroid dehydrogenase). [swissprot;acc:q04828]	1897	AKR1C1		201.286	197.384	1.01977
aldo-keto reductase family 1 member c2 (ec 1.1.1.-) (trans-1,2- dihydrobenzene-1,2-diol dehydrogenase) (ec 1.3.1.20) (chlordecone reductase homolog hakrd) (dihydrodiol dehydrogenase/bile acid-binding protein) (dd/babp) (dihydrodiol dehydrogenase 2) (dd2). [swissprot;acc:p52895]	1900	AKR1C2
aldo-keto reductase family 1 member c4 (ec 1.1.1.-) (chlordecone reductase) (ec 1.1.1.225) (cdr) (3-alpha-hydroxysteroid dehydrogenase) (ec 1.1.1.50) (3-alpha-hsd) (dihydrodiol dehydrogenase 4) (dd4) (hakra). [swissprot;acc:p17516]	1903	no value
aldo-keto reductase loopadr; aldo-keto reductase related protein. [refseq;acc:nm_031436]	1899	AKR1CL2
aldose reductase (ec 1.1.1.21) (ar) (aldehyde reductase). [swissprot;acc:p15121]	2553	AKR1B1		201.278	197.708	1.01806
alkaline phytoceramidase (ec 3.5.1.-) (aphc) (alkaline ceramidase) (alkaline dihydroceramidase sb89). [swissprot;acc:q9nun7]	2555	PHCA		200.327	196.774
all1 fused gene from 5q31. [refseq;acc:nm_014423]	373	AFF4		219.598	211.722	1.0372
alpha 2 globin. [refseq;acc:nm_000517]	511	no value		205.157	198.715	1.03242
alpha adducin (erythrocyte adducin alpha subunit). [swissprot;acc:p35611]	1628	ADD1		205.76	201.569	1.02079
	1965		High confidence	224.432	222.258	1.00978
alpha crystallin a chain. [swissprot;acc:p02489]	199	CRYAA	Low confidence	219.589	208.895	1.05119
	2875		High confidence	0.00001	0.00001	1
alpha crystallin b chain (alpha(b)-crystallin) (rosenthal fiber component). [swissprot;acc:p02511]	200	CRYAB	Low confidence	219.543	208.868	1.05111
	3082		High confidence	0.00001	0.00001	1
alpha crystallin c chain (small stress protein-like protein hsp22) (e2ig1) (protein kinase h11). [swissprot;acc:q9ujy1]	1450	HSPB8		221.804	226.194	1.01979
	4001		Low confidence	205.873	203.49	1.01171
alpha enolase (ec 4.2.1.11) (2-phospho-d-glycerate hydro-lyase) (non- neural enolase) (nne) (enolase 1) (phosphopyruvate hydratase). [swissprot;acc:p06733]	2363	ENO1	High confidence	207.186	208.046	1.00415
	4639		Low confidence	202.002	200.683	1.00657
alpha glucosidase ii alpha subunit; likely ortholog of mouse g2an alpha glucosidase 2, alpha neutral subunit. [refseq;acc:nm_014610]	2536	GANAB		198.976	195.437	1.01811
alpha-(1,6)-fucosyltransferase (ec 2.4.1.68) (glycoprotein 6-alpha-l- fucosyltransferase) (gdp-fucose--glycoprotein fucosyltransferase) (gdp-l-fuc:n-acetyl-beta-d-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6fuct) (fucosyltransferase 8). [swissprot;acc:q9byc5]	1726	FUT8	High confidence	217.676	220.53	1.01311
	3767		Low confidence	200.573	197.917	1.01342

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.