MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 551 to 600 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	Interaction Map	red	network_comparison	green
138	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	PPP2CA	Divided	High confidence	194.372	1.20493	234.204
	transgelin 2 (sm22-alpha homolog). [swissprot;acc:p37802]	no value		Low confidence	218.36	1.0631	205.4
139	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	APBA1		High confidence	271.752	1.20415	225.68
	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	CHRAC1	Subtracted		287.41	30.575	256.835
	dnaj homolog subfamily c member 8 (splicing protein spf31) (hspc315). [swissprot;acc:o75937]	DNAJC8		Low confidence	219.838	12.421	207.417
	testican-1 precursor (spock protein). [swissprot;acc:q08629]	SPOCK1	Divided		220.254	1.06291	234.111
140	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	NCBP2	Subtracted	High confidence	228.306	30.295	198.011
	c3hc4-type zinc finger protein; likely ortholog of mouse dioxin inducible factor 3. [refseq;acc:nm_024835]	GGNBP2		Low confidence	219.838	12.421	207.417
	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	RRAGA	Divided	High confidence	59	1.20408	49
	testican-2 precursor. [swissprot;acc:q92563]	SPOCK2		Low confidence	220.222	1.06278	234.047
141	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	COMP	Subtracted	High confidence	239.991	29.247	269.238
	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ec 3.2.1.113) (er alpha-1,2-mannosidase) (mannosidase alpha class 1b member 1) (man9glcnac2-specific processing alpha-mannosidase). [swissprot;acc:q9ukm7]	MAN1B1		Low confidence	211.056	12.324	198.732
	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	RRAGC	Divided	High confidence	59	1.20408	49
	rho guanine nucleotide exchange factor 7 (pak-interacting exchange factor beta) (beta-pix) (cool-1) (p85). [swissprot;acc:q14155]	ARHGEF7		Low confidence	219.344	1.0621	206.52
142	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ec 3.2.1.113) (er alpha-1,2-mannosidase) (mannosidase alpha class 1b member 1) (man9glcnac2-specific processing alpha-mannosidase). [swissprot;acc:q9ukm7]	MAN1B1			211.056	1.06201	198.732
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	PSEN2	Subtracted			12.324
	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	RRAGB	Divided	High confidence	59	1.20408	49
	thrombospondin 3 precursor. [swissprot;acc:p49746]	THBS3	Subtracted		239.99	29.244	269.234
143	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	ANLN	Divided		59	1.20408	49
	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	FBXW7	Subtracted	Low confidence	211.056	12.324	198.732
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	PSEN2	Divided			1.06201
	splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164]	SF4	Subtracted	High confidence	240.133	28.751	211.382
144	cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291]	CSRP1			239.35	28.565	267.915
	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	FBXW7	Divided	Low confidence	211.056	1.06201	198.732
	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	KCNIP1		High confidence	265.686	1.20312	319.651
	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	PSEN1	Subtracted	Low confidence	211.056	12.324	198.732
145	likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745]	SHCBP1		High confidence	239.336	28.545	267.881
	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	KCNIP4	Divided		265.639	1.20293	319.546
	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	PSEN1		Low confidence	211.056	1.06201	198.732
	sentrin-specific protease 8 (ec 3.4.22.-) (sentrin/sumo-specific protease senp8) (cysteine protease fksg8). [swissprot;acc:q96ld8]	SENP8	Subtracted		210.579	12.249	198.33
146	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	KCNIP2	Divided	High confidence	265.632	1.20291	319.531
	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	NDUFS4		Low confidence	226.892	1.06193	213.661
	smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527]	CSRP2	Subtracted	High confidence	239.336	28.543	267.879
	ubiquitin-like protein nedd8. [swissprot;acc:q15843]	NEDD8		Low confidence	210.579	12.249	198.33
147	calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384]	CAPN1			222.508	12.163	210.345
	lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461]	CSRP3		High confidence	239.32	28.522	267.842
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	no value	Divided		50.7983	1.2009	42.3003
	rho guanine nucleotide exchange factor 6 (pak-interacting exchange factor alpha) (alpha-pix) (cool-2). [swissprot;acc:q15052]	ARHGEF6		Low confidence	219.273	1.06182	206.507
148	calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655]	CAPN2	Subtracted		222.502	12.16	210.342
	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	FLNB		High confidence	226.582	28.138	198.444
	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	UNC84A	Divided		296.677	1.19841	247.559
	sentrin-specific protease 8 (ec 3.4.22.-) (sentrin/sumo-specific protease senp8) (cysteine protease fksg8). [swissprot;acc:q96ld8]	SENP8		Low confidence	210.579	1.06176	198.33
149	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	no value		High confidence	142	1.19718	170
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	HMG20B	Subtracted	Low confidence	202.996	12.142	190.854
	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	REV1		High confidence	226.582	28.138	198.444
	ubiquitin-like protein nedd8. [swissprot;acc:q15843]	NEDD8	Divided	Low confidence	210.579	1.06176	198.33
150	cathepsin l2 precursor (ec 3.4.22.43) (cathepsin v) (cathepsin u). [swissprot;acc:o60911]	CTSL2	Subtracted		211.818	12.084	199.734
	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	MYO5B	Divided	High confidence	55	1.19565	46
	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	PRMT1	Subtracted		226.582	28.138	198.444
	serine/threonine-protein kinase plk (ec 2.7.1.-) (plk-1) (serine- threonine protein kinase 13) (stpk13). [swissprot;acc:p53350]	PLK1	Divided	Low confidence	206.516	1.06148	194.554

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.