MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 551 to 600 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Value Type	red	network_comparison	green
138	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	UBAC1	Squared	468498	1.45156	322755
	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	PPP2CA	Ranked	194.372	1.20493	234.204
139	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	APBA1		271.752	1.20415	225.68
	g2/mitotic-specific cyclin b2. [swissprot;acc:o95067]	CCNB2	Squared	81592.1	1.45153	56211.1
	nuclear protein ukp68. [refseq;acc:nm_024824]	ZC3H14	Rooted	54.9787	1.20486	66.2416
	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	KCNIP4	Measured	2759.61	1.31442	2099.49
140	cell division protein kinase 2 (ec 2.7.1.-) (p33 protein kinase). [swissprot;acc:p24941]	CDK2	Squared	81527.6	1.45091	56190.6
	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	FLNB	Rooted	55.6161	1.19989	66.7332
	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	KCNIP2	Measured	2760.28	1.31425	2100.27
	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	RRAGA	Ranked	59	1.20408	49
141	g2/mitotic-specific cyclin b1. [swissprot;acc:p14635]	CCNB1	Squared	81520.8	1.45084	56188.5
	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	RRAGC	Ranked	59	1.20408	49
	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	REV1	Rooted	55.6161	1.19989	66.7332
	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	SNRPD2	Measured	4405.4	1.3125	5782.08
142	cell division control protein 2 homolog (ec 2.7.1.-) (p34 protein kinase) (cyclin-dependent kinase 1) (cdk1). [swissprot;acc:p06493]	CDC2	Squared	81478.9	1.45044	56175.2
	metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889]	PITRM1	Measured	9276.47	1.30832	7090.37
	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	PRMT1	Rooted	55.6161	1.19989	66.7332
	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	RRAGB	Ranked	59	1.20408	49
143	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	ANLN
	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]	ALG1	Measured	9275.1	1.30826	7089.65
	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	PRMT8	Rooted	55.6161	1.19989	66.7332
	protein phosphatase 1, regulatory (inhibitor) subunit 13b; apoptosis-stimulating protein of p53, 1. [refseq;acc:nm_015316]	PPP1R13B	Squared	124319	1.43145	86848.2
144	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	KCNIP1	Ranked	265.686	1.20312	319.651
	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	UNC84A	Measured	3349.9	1.30231	4362.61
	tumor suppressor p53-binding protein 2 (p53-binding protein 2) (53bp2) (bcl2-binding protein) (bbp). [swissprot;acc:q13625]	TP53BP2	Squared	123324	1.42938	86277.9
	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	SNRP70	Rooted	55.6161	1.19989	66.7332
145	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	no value
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]		Squared	310840	1.42515	442993
	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	KCNIP4	Ranked	265.639	1.20293	319.546
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	no value	Measured	16771.5	1.30122	12889.1
146	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	STAMBPL1		11068	1.30082	8508.5
	huntingtin interacting protein c. [refseq;acc:nm_012272]	PRPF40B	Rooted	55.0737	1.19894	66.0298
	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	KCNIP2	Ranked	265.632	1.20291	319.531
	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	RRAGA	Squared	103496	1.41888	146848
147	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	FOXP4	Rooted	42.0574	1.19893	50.4237
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	no value	Ranked	50.7983	1.2009	42.3003
	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	CHMP2A	Measured	11068	1.30082	8508.5
	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	RRAGC	Squared	103496	1.41888	146848
148	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	STAMBP	Measured	11068	1.30082	8508.5
	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	FOXP1	Rooted	42.0577	1.19892	50.424
	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	RRAGB	Squared	103496	1.41888	146848
	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	UNC84A	Ranked	296.677	1.19841	247.559
149	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	ANLN	Squared	103496	1.41888	146848
	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	no value	Ranked	142	1.19718	170
	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	FOXP3	Rooted	42.0684	1.19882	50.4323
	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	VPS24	Measured	11068	1.30082	8508.5
150	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	MYO5B	Ranked	55	1.19565	46
	pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989]	CLP1	Squared	121200	1.41799	85473.4
	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	CHMP4A	Measured	11068	1.30082	8508.5
	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	PPP2CA	Rooted	63.5827	1.19774	53.0856

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.