MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 5408 to 5457 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
2704	gk001 protein. [refseq;acc:nm_020198]	CCDC47	High confidence	188.435	188.311	1.00066
2705	calsyntenin-2 precursor. [swissprot;acc:q9h4d0]	CLSTN2		188.457	188.334	1.00065
	rna-binding protein 9 (rna binding motif protein 9) (hexaribonucleotide binding protein 2) (repressor of tamoxifen transcriptional activity). [swissprot;acc:o43251]	RBM9	Low confidence	203.729	200.215	1.01755
2706	6-phosphofructokinase, type c (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme c) (pfk-c) (6-phosphofructokinase, platelet type). [swissprot;acc:q01813]	PFKP		200.868	197.403
	calsyntenin-3 precursor. [swissprot;acc:q9bqt9]	CLSTN3	High confidence	188.459	188.336	1.00065
2707	ariadne-1 protein homolog (ari-1) (ubiquitin-conjugating enzyme e2- binding protein 1) (ubch7-binding protein) (ubcm4-interacting protein) (hhari) (h7-ap2) (hussy-27) (mop-6). [swissprot;acc:q9y4x5]	ARIH1	Low confidence	186.752	183.532	1.01754
	red cell acid phosphatase 1, isozyme f (ec 3.1.3.2) (acp1) (low molecular weight phosphotyrosine protein phosphatase) (ec 3.1.3.48) (adipocyte acid phosphatase, isozyme alpha). [swissprot;acc:p24666]	ACP1	High confidence	215.096	215.232	1.00063
2708	porphobilinogen deaminase (ec 4.3.1.8) (hydroxymethylbilane synthase) (hmbs) (pre-uroporphyrinogen synthase) (pbg-d). [swissprot;acc:p08397]	HMBS		227.796	227.66	1.0006
	serine/threonine-protein kinase h1 (ec 2.7.1.37) (psk-h1). [swissprot;acc:p11801]	PSKH1	Low confidence	197.044	193.647	1.01754
2709	importin 7; ran-binding protein 7. [refseq;acc:nm_006391]	no value	High confidence	220.521	220.395	1.00057
	t-complex associated-testis-expressed 1-like (protein 91/23). [swissprot;acc:p51808]	DYNLT3	Low confidence	200.907	197.446	1.01753
2710	importin 8; ran-binding protein 8. [refseq;acc:nm_006390]	IPO8	High confidence	220.521	220.395	1.00057
	thioredoxin domain containing; thioredoxin-related transmembrane protein; thioredoxin domain-containing. [refseq;acc:nm_030755]	TXNDC1	Low confidence	201.438	197.967	1.01753
2711	brefeldin a-inhibited guanine nucleotide-exchange protein 2 (brefeldin a-inhibited gep 2). [swissprot;acc:q9y6d5]	ARFGEF2	High confidence	220.521	220.395	1.00057
	myosin heavy chain 14. [refseq;acc:nm_024729]	MYH14	Low confidence	200.598	197.143	1.01753
2712	double-strand break repair protein mre11a (mre11 homolog 1). [swissprot;acc:p49959]	MRE11A		200.907	197.446
	hsgcn1 (fragment). [sptrembl;acc:q99736]	GCN1L1	High confidence	220.521	220.395	1.00057
2713	acetyl-coenzyme a transporter. [refseq;acc:nm_004733]	SLC33A1	Low confidence	201.627	198.156	1.01752
	brefeldin a-inhibited guanine nucleotide-exchange protein 1 (brefeldin a-inhibited gep 1) (p200 arf-gep1) (p200 arf guanine nucleotide exchange factor). [swissprot;acc:q9y6d6]	ARFGEF1	High confidence	220.521	220.395	1.00057
2714	40s ribosomal protein s30. [swissprot;acc:q05472]	FAU	Low confidence	202.521	199.033	1.01752
	similar to trna synthetase class ii. [refseq;acc:nm_152268]	PARS2	High confidence	220.224	220.348	1.00056
2715	basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811]	no value		216.018	215.903	1.00053
	lanc lantibiotic synthetase component c-like 2; testis-specific adriamycin sensitivity protein; lanc (bacterial lantibiotic synthetase component c)-like 2; g protein-coupled receptor 69b. [refseq;acc:nm_018697]	LANCL2	Low confidence	201.887	198.411	1.01752
2716	rna-binding protein 8a (rna binding motif protein 8a) (ribonucleoprotein rbm8a) (rna-binding protein y14) (binder of ovca1- 1) (bov-1). [swissprot;acc:q9y5s9]	RBM8A		200.124	196.679
	salivary proline-rich protein po (allele k) [contains: peptide p-d] (fragment). [swissprot;acc:p10162]	PRB4	High confidence	216.018	215.903	1.00053
2717	eukaryotic translation initiation factor 2 subunit 2 (eukaryotic translation initiation factor 2 beta subunit) (eif-2-beta). [swissprot;acc:p20042]	EIF2S2	Low confidence	200.642	197.188	1.01752
	microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268]	MAPRE2	High confidence	216.521	216.634	1.00052
2718	histidine-rich membrane protein ke4. [swissprot;acc:q92504]	SLC39A7		216.52	216.632
	lanthionine synthetase c-like protein 1; g protein-coupled receptor 69a; lanc (bacterial lantibiotic synthetase component c)-like 1; lanc (bacterial lantibiotic synthetase component). [refseq;acc:nm_006055]	LANCL1	Low confidence	201.887	198.411	1.01752
2719	microtubule-associated protein rp/eb family member 1 (apc-binding protein eb1). [swissprot;acc:q15691]	MAPRE1	High confidence	216.52	216.632	1.00052
	zinc ribbon domain containing, 1; transcription-associated zinc ribbon protein; rna polymerase i small specific subunit rpa12. [refseq;acc:nm_014596]	ZNRD1	Low confidence	201.627	198.156	1.01752
2720	calcium/calmodulin-dependent protein kinase ig. [refseq;acc:nm_020439]	CAMK1G		197.012	193.62
	microtubule-associated protein rp/eb family member 3 (protein eb3). [swissprot;acc:q9upy8]	MAPRE3	High confidence	216.52	216.633	1.00052
2721	bifunctional aminoacyl-trna synthetase [includes: glutamyl-trna synthetase (ec 6.1.1.17) (glutamate--trna ligase); prolyl-trna synthetase (ec 6.1.1.15) (proline--trna ligase)]. [swissprot;acc:p07814]	EPRS		221.022	221.116	1.00043
	calcium/calmodulin-dependent protein kinase type i (ec 2.7.1.123) (cam kinase i). [swissprot;acc:q14012]	CAMK1	Low confidence	197.004	193.613	1.01751
2722	camki-like protein kinase beta isoform. [refseq;acc:nm_153498]	CAMK1D		196.985	193.597	1.0175
	transducin beta-like 2 protein (ws beta-transducin repeats protein) (ws-betatrp) (williams-beuren syndrome chromosome region 13 protein). [swissprot;acc:q9y4p3]	TBL2	High confidence	219.308	219.214	1.00043
2723	epithelial discoidin domain receptor 1 precursor (ec 2.7.1.112) (tyrosine-protein kinase cak) (cell adhesion kinase) (tyrosine kinase ddr) (discoidin receptor tyrosine kinase) (trk e) (protein-tyrosine kinase rtk 6) (cd167a antigen). [swissprot;acc:q08345]	DDR1	Low confidence	200.785	197.332	1.0175
	lamin b2. [swissprot;acc:q03252]	no value	High confidence	219.323	219.413	1.00041
2724	discoidin domain receptor 2 precursor (ec 2.7.1.112) (receptor protein-tyrosine kinase tkt) (tyrosine-protein kinase tyro 10) (neurotrophic tyrosine kinase, receptor-related 3). [swissprot;acc:q16832]	DDR2	Low confidence	200.78	197.329	1.01749
	heat shock protein hsp 90-beta (hsp 84) (hsp 90). [swissprot;acc:p08238]	HSP90AB1	High confidence	221.053	220.963	1.00041
2725	doublecortin (lissencephalin-x) (lis-x) (doublin). [swissprot;acc:o43602]	DCX		216.496	216.569	1.00034
	splicing factor u2af 65 kda subunit (u2 auxiliary factor 65 kda subunit) (u2 snrnp auxiliary factor large subunit) (hu2af(65)). [swissprot;acc:p26368]	U2AF2	Low confidence	201.526	198.062	1.01749
2726	rad17 homolog isoform 1; rad17-like protein; cell cycle checkpoint protein (rad17); rf-c activator 1 homolog. [refseq;acc:nm_002873]	RAD17	High confidence	221.001	220.927	1.00033
	serpin b12. [swissprot;acc:q96p63]	SERPINB12	Low confidence	199.881	196.448	1.01748
2727	atp-dependent dna helicase ii, 70 kda subunit (lupus ku autoantigen protein p70) (ku70) (70 kda subunit of ku antigen) (thyroid-lupus autoantigen) (tlaa) (ctc box binding factor 75 kda subunit) (ctcbf) (ctc75). [swissprot;acc:p12956]	no value	High confidence	221.001	220.927	1.00033
	megsin (tp55) (serpin b7). [swissprot;acc:o75635]	SERPINB7	Low confidence	199.881	196.448	1.01748
2728	atp-dependent dna helicase ii, 80 kda subunit (lupus ku autoantigen protein p86) (ku86) (ku80) (86 kda subunit of ku antigen) (thyroid- lupus autoantigen) (tlaa) (ctc box binding factor 85 kda subunit) (ctcbf) (ctc85) (nuclear factor iv) (dna-repair protein xrcc5). [swissprot;acc:p13010]	XRCC5	High confidence	221.001	220.927	1.00033
	hepatocyte nuclear factor 4-gamma (hnf-4-gamma). [swissprot;acc:q14541]	HNF4G	Low confidence	202.352	198.876	1.01748
2729	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	no value		199.881	196.448

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.