MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 512 to 561 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
128	Rooted	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	48.0515	39.0445	1.23069
129	Measured	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	4358.13	5811.49	1.33348
	Ranked	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	94	114	1.21277
	Squared	pre-mrna cleavage complex ii protein pcf11 (fragment). [swissprot;acc:o94913]	178263	118639	1.50257
	Rooted	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	54.2343	66.7323	1.23044
130	Measured	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	2234.68	2978.53	1.33287
	Ranked	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	94	114	1.21277
	Squared	44050 protein. [refseq;acc:nm_178832]	148058	99628.4	1.4861
	Rooted	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	55.1026	67.5701	1.22626
131	Measured	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	2234.73	2978.57	1.33285
	Ranked	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	294.053	242.562	1.21228
	Squared	nuclear inhibitor of protein phosphatase-1 (nipp-1) (protein phosphatase 1, regulatory inhibitor subunit 8) [includes: activator of rna decay (ec 3.1.4.-) (ard-1)]. [swissprot;acc:q12972]	148058	99628.4	1.4861
	Rooted	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	55.1113	67.5537	1.22577
132	Measured	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	2236.61	2980.35	1.33253
	Ranked	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	350	290	1.2069
	Squared	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	36359.2	24466.8	1.48606
	Rooted	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	44.963	55.0576	1.22451
133	Measured	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	23421.5	17580.4	1.33225
	Ranked	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	350	290	1.2069
	Squared	gbp protein isoform a. [refseq;acc:nm_017870]	1182.25	1726.55	1.46039
	Rooted	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	45.4558	55.5995	1.22316
134	Measured	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	21785.2	16426.1	1.32626
	Ranked	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	350	290	1.2069
	Squared	p66 alpha. [refseq;acc:nm_017660]	81888.8	56306.5	1.45434
	Rooted	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	44.849	54.7964	1.2218
135	Measured	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	21785.2	16426.1	1.32626
	Ranked	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	350	290	1.2069
	Squared	transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	81888.8	56306.5	1.45434
	Rooted	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	54.935	66.6101	1.21253
136	Measured	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	3620.77	4763.34	1.31556
	Ranked	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	350	290	1.2069
	Squared	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	81888.8	56306.5	1.45434
	Rooted	adiponectin receptor 2. [refseq;acc:nm_024551]	41.8357	50.6469	1.21061
137	Measured	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	3620.77	4763.34	1.31556
	Ranked	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	350	290	1.2069
	Squared	cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]	81606.8	56215.8	1.45167
	Rooted	musashi 2 isoform a. [refseq;acc:nm_138962]	54.9787	66.2416	1.20486
138	Measured	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	2755.15	2094.3	1.31555
	Ranked	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	194.372	234.204	1.20493
	Squared	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	468498	322755	1.45156
	Rooted	musashi 1. [refseq;acc:nm_002442]	54.9787	66.2416	1.20486
139	Measured	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	2759.61	2099.49	1.31442
	Ranked	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	271.752	225.68	1.20415
	Squared	g2/mitotic-specific cyclin b2. [swissprot;acc:o95067]	81592.1	56211.1	1.45153
	Rooted	nuclear protein ukp68. [refseq;acc:nm_024824]	54.9787	66.2416	1.20486
140	Measured	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	2760.28	2100.27	1.31425
	Ranked	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	59	49	1.20408
	Squared	cell division protein kinase 2 (ec 2.7.1.-) (p33 protein kinase). [swissprot;acc:p24941]	81527.6	56190.6	1.45091
	Rooted	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	55.6161	66.7332	1.19989
141	Measured	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	4405.4	5782.08	1.3125

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.