MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Network Comparison Type	Gene	description	Hugo	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 501 to 550 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Network Comparison Type	description	Hugo	Interaction Map	red	green	network_comparison
126	Divided	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	STAMBPL1	High confidence	94	114	1.21277
		lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	LASS2	Low confidence	191.688	179.639	1.06707
	Subtracted	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	FBXW7	High confidence	285.684	252.234	33.45
		nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	NDUFS4	Low confidence	226.892	213.661	13.231
127	Divided	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	CHMP2A	High confidence	94	114	1.21277
		vacuolar protein sorting 33b (hvps33b). [swissprot;acc:q9h267]	VPS33B	Low confidence	203.678	190.88	1.06705
	Subtracted	adenomatous polyposis coli protein (apc protein). [swissprot;acc:p25054]	APC		222.31	235.538	13.228
		cullin homolog 2 (cul-2). [swissprot;acc:q13617]	CUL2	High confidence	285.684	252.234	33.45
128	Divided	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	STAMBP		94	114	1.21277
		striatin. [swissprot;acc:o43815]	STRN	Low confidence	214.085	200.796	1.06618
	Subtracted	adenomatous polyposis coli like. [refseq;acc:nm_005883]	APC2		222.34	235.547	13.207
		presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	PSEN1	High confidence	285.684	252.234	33.45
129	Divided	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]	COL4A3BP	Low confidence	220.969	235.572	1.06609
		neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	VPS24	High confidence	94	114	1.21277
	Subtracted	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	CUL1		285.684	252.234	33.45
		transgelin (smooth muscle protein 22-alpha) (sm22-alpha) (ws3-10) (22 kda actin-binding protein). [swissprot;acc:q01995]	TAGLN	Low confidence	218.561	205.431	13.13
130	Divided	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	CHMP4A	High confidence	94	114	1.21277
		striated muscle activator of rho-dependent signaling. [refseq;acc:nm_139166]	ABRA	Low confidence	225.495	211.529	1.06602
	Subtracted	neuronal protein np25. [swissprot;acc:q9ui15]	TAGLN3		218.66	205.57	13.09
		palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	EGFL8	High confidence	242.735	276.059	33.324
131	Divided	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	SON		294.053	242.562	1.21228
		striatin 4 (zinedin). [swissprot;acc:q9nrl3]	STRN4	Low confidence	213.878	200.825	1.065
	Subtracted	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	EGFL7	High confidence	242.718	276.018	33.3
		striatin 4 (zinedin). [swissprot;acc:q9nrl3]	STRN4	Low confidence	213.878	200.825	13.053
132	Divided	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	DAZAP1		220.268	206.997	1.06411
		tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	TOB2	High confidence	350	290	1.2069
	Subtracted	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	NCBP2L		229.406	196.695	32.711
		segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	DVL1	Low confidence	203.016	189.965	13.051
133	Divided	prominin-like protein 1 precursor (antigen ac133) (cd133 antigen). [swissprot;acc:o43490]	PROM1		220.268	206.997	1.06411
		tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	TOB1	High confidence	350	290	1.2069
	Subtracted	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	no value		226.887	194.72	32.167
		segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	DVL2	Low confidence	203.007	189.985	13.022
134	Divided	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	DAB2IP	High confidence	350	290	1.2069
		transgelin (smooth muscle protein 22-alpha) (sm22-alpha) (ws3-10) (22 kda actin-binding protein). [swissprot;acc:q01995]	TAGLN	Low confidence	218.561	205.431	1.06391
	Subtracted	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	no value	High confidence	226.884	194.79	32.094
		transgelin 2 (sm22-alpha homolog). [swissprot;acc:p37802]		Low confidence	218.36	205.4	12.96
135	Divided	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	CPEB4	High confidence	350	290	1.2069
		neuronal protein np25. [swissprot;acc:q9ui15]	TAGLN3	Low confidence	218.66	205.57	1.06368
	Subtracted	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	FOXP4	High confidence	263.215	231.407	31.808
		segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	DVL3	Low confidence	202.96	190.094	12.866
136	Divided	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	CPEB3	High confidence	350	290	1.2069
		high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	HMG20B	Low confidence	202.996	190.854	1.06362
	Subtracted	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	FOXP1	High confidence	263.215	231.407	31.808
		rho guanine nucleotide exchange factor 7 (pak-interacting exchange factor beta) (beta-pix) (cool-1) (p85). [swissprot;acc:q14155]	ARHGEF7	Low confidence	219.344	206.52	12.824
137	Divided	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	RASAL2	High confidence	350	290	1.2069
		testican-3 precursor. [swissprot;acc:q9bq16]	no value	Low confidence	220.395	234.389	1.0635
	Subtracted	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	FOXP3	High confidence	263.191	231.394	31.797
		vacuolar protein sorting 33b (hvps33b). [swissprot;acc:q9h267]	VPS33B	Low confidence	203.678	190.88	12.798
138	Divided	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	PPP2CA	High confidence	194.372	234.204	1.20493
		transgelin 2 (sm22-alpha homolog). [swissprot;acc:p37802]	no value	Low confidence	218.36	205.4	1.0631

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.