MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 501 to 550 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Hugo	red	network_comparison	green
alpha crystallin c chain (small stress protein-like protein hsp22) (e2ig1) (protein kinase h11). [swissprot;acc:q9ujy1]	Divided	1450	HSPB8	221.804	1.01979	226.194
	Subtracted	1397			4.39
alpha enolase (ec 4.2.1.11) (2-phospho-d-glycerate hydro-lyase) (non- neural enolase) (nne) (enolase 1) (phosphopyruvate hydratase). [swissprot;acc:p06733]	Divided	2363	ENO1	207.186	1.00415	208.046
	Subtracted	2365			0.86
alpha-(1,6)-fucosyltransferase (ec 2.4.1.68) (glycoprotein 6-alpha-l- fucosyltransferase) (gdp-fucose--glycoprotein fucosyltransferase) (gdp-l-fuc:n-acetyl-beta-d-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6fuct) (fucosyltransferase 8). [swissprot;acc:q9byc5]	Divided	1726	FUT8	217.676	1.01311	220.53
	Subtracted	1710			2.854
alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]	Divided	1189	no value	209.649	1.02565	204.406
	Subtracted	1232			5.243
alpha-1-syntrophin (59 kda dystrophin-associated protein a1, acidic component 1) (pro-tgf-alpha cytoplasmic domain-interacting protein 1) (tacip1) (syntrophin 1). [swissprot;acc:q13424]	Divided	2587	SNTA1	213.422	1.00154	213.75
	Subtracted				0.328
alpha-actinin 1 (alpha-actinin cytoskeletal isoform) (non-muscle alpha-actinin 1) (f-actin cross linking protein). [swissprot;acc:p12814]	Divided	1806	ACTN1	217.009	1.01178	214.482
	Subtracted	1791			2.527
alpha-actinin 2 (alpha actinin skeletal muscle isoform 2) (f-actin cross linking protein). [swissprot;acc:p35609]	Divided	1799	ACTN2	217.016	1.01182	214.481
	Subtracted	1787			2.535
alpha-actinin 4 (non-muscle alpha-actinin 4) (f-actin cross linking protein). [swissprot;acc:o43707]	Divided	1805	ACTN4	217.008	1.01178	214.482
	Subtracted	1792			2.526
alpha-centractin (centractin) (centrosome-associated actin homolog) (actin-rpv) (arp1). [swissprot;acc:p42024]	Divided	1509	ACTR1A	225.148	1.01795	221.177
	Subtracted	1481			3.971
alpha-fetoprotein enhancer binding protein (at motif-binding factor) (at-binding transcription factor 1). [swissprot;acc:q15911]	Divided	2255	ZFHX3	202.366	1.00595	203.57
	Subtracted	2257			1.204
alpha-nac protein. [sptrembl;acc:q9h009]	Divided	889	no value	212.028	1.03908	204.053
	Subtracted	900			7.975
alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	Divided	1249		219.354	1.02437	224.7
	Subtracted	1188			5.346
alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]	Divided	812	NAPA	212.386	1.04425	221.785
	Subtracted	800			9.399
alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]	Divided	1961	ABHD1	211.633	1.00978	213.703
	Subtracted	1931			2.07
alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340]	Divided	1959	ABHD3		1.00978
	Subtracted	1929			2.07
alveolar soft part sarcoma chromosome region, candidate 1; aspl protein; renal cell carcinoma gene on chromosome 17; renal cell carcinoma, papillary, 17 gene; aspscr1/tfe3 fusion gene, included. [refseq;acc:nm_024083]	Divided	2829	ASPSCR1	0.00001	1	0.00001
	Subtracted			0	0	0
amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]	Divided	637	PPAT	228.639	1.05957	242.258
	Subtracted	569			13.619
aminoacylase-1 (ec 3.5.1.14) (n-acyl-l-amino-acid amidohydrolase) (acy-1). [swissprot;acc:q03154]	Divided	1420	ACY1	203.979	1.02084	208.229
	Subtracted	1424			4.25
aminoadipate-semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase. [refseq;acc:nm_005763]	Divided	2064	AASS	207.655	1.00833	205.939
	Subtracted	2067			1.716
aminomethyltransferase, mitochondrial precursor (ec 2.1.2.10) (glycine cleavage system t protein) (gcvt). [swissprot;acc:p48728]	Divided	2544	AMT	212.67	1.00192	212.262
	Subtracted	2537			0.408
ammecr1 protein. [refseq;acc:nm_015365]	Divided	1577	AMMECR1	222.585	1.01645	218.982
	Subtracted	1562			3.603
amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	Divided	52	AMPD2	133	1.26667	105
	Subtracted	167			28
amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	Divided	139	APBA1	271.752	1.20415	225.68
	Subtracted	97			46.072
amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905]	Divided	2490	APPBP1	194.527	1.00284	195.08
	Subtracted	2501			0.553
amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail)-binding protein 2; protein interacting with app tail 1. [refseq;acc:nm_006380]	Divided	3191	APPBP2	0.00001	1	0.00001
	Subtracted			0	0	0

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.