MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 501 to 550 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
126	FBXW7	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	Subtracted	High confidence	285.684	252.234	33.45
	LASS2	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	Divided	Low confidence	191.688	179.639	1.06707
	NDUFS4	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	Subtracted		226.892	213.661	13.231
	STAMBPL1	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	Divided	High confidence	94	114	1.21277
127	APC	adenomatous polyposis coli protein (apc protein). [swissprot;acc:p25054]	Subtracted	Low confidence	222.31	235.538	13.228
	CHMP2A	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	Divided	High confidence	94	114	1.21277
	CUL2	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	Subtracted		285.684	252.234	33.45
	VPS33B	vacuolar protein sorting 33b (hvps33b). [swissprot;acc:q9h267]	Divided	Low confidence	203.678	190.88	1.06705
128	APC2	adenomatous polyposis coli like. [refseq;acc:nm_005883]	Subtracted		222.34	235.547	13.207
	PSEN1	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]		High confidence	285.684	252.234	33.45
	STAMBP	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	Divided		94	114	1.21277
	STRN	striatin. [swissprot;acc:o43815]		Low confidence	214.085	200.796	1.06618
129	COL4A3BP	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]			220.969	235.572	1.06609
	CUL1	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	Subtracted	High confidence	285.684	252.234	33.45
	TAGLN	transgelin (smooth muscle protein 22-alpha) (sm22-alpha) (ws3-10) (22 kda actin-binding protein). [swissprot;acc:q01995]		Low confidence	218.561	205.431	13.13
	VPS24	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	Divided	High confidence	94	114	1.21277
130	ABRA	striated muscle activator of rho-dependent signaling. [refseq;acc:nm_139166]		Low confidence	225.495	211.529	1.06602
	CHMP4A	protein hspc134 (protein cda04). [swissprot;acc:q9by43]		High confidence	94	114	1.21277
	EGFL8	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	Subtracted		242.735	276.059	33.324
	TAGLN3	neuronal protein np25. [swissprot;acc:q9ui15]		Low confidence	218.66	205.57	13.09
131	EGFL7	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]		High confidence	242.718	276.018	33.3
	SON	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Divided		294.053	242.562	1.21228
	STRN4	striatin 4 (zinedin). [swissprot;acc:q9nrl3]		Low confidence	213.878	200.825	1.065
			Subtracted				13.053
132	DAZAP1	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	Divided		220.268	206.997	1.06411
	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	Subtracted		203.016	189.965	13.051
	NCBP2L	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]		High confidence	229.406	196.695	32.711
	TOB2	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Divided		350	290	1.2069
133	no value	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Subtracted		226.887	194.72	32.167
	DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]		Low confidence	203.007	189.985	13.022
	PROM1	prominin-like protein 1 precursor (antigen ac133) (cd133 antigen). [swissprot;acc:o43490]	Divided		220.268	206.997	1.06411
	TOB1	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]		High confidence	350	290	1.2069
134	no value	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Subtracted		226.884	194.79	32.094
		transgelin 2 (sm22-alpha homolog). [swissprot;acc:p37802]		Low confidence	218.36	205.4	12.96
	DAB2IP	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Divided	High confidence	350	290	1.2069
	TAGLN	transgelin (smooth muscle protein 22-alpha) (sm22-alpha) (ws3-10) (22 kda actin-binding protein). [swissprot;acc:q01995]		Low confidence	218.561	205.431	1.06391
135	CPEB4	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]		High confidence	350	290	1.2069
	DVL3	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	Subtracted	Low confidence	202.96	190.094	12.866
	FOXP4	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]		High confidence	263.215	231.407	31.808
	TAGLN3	neuronal protein np25. [swissprot;acc:q9ui15]	Divided	Low confidence	218.66	205.57	1.06368
136	ARHGEF7	rho guanine nucleotide exchange factor 7 (pak-interacting exchange factor beta) (beta-pix) (cool-1) (p85). [swissprot;acc:q14155]	Subtracted		219.344	206.52	12.824
	CPEB3	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Divided	High confidence	350	290	1.2069
	FOXP1	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	Subtracted		263.215	231.407	31.808
	HMG20B	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Divided	Low confidence	202.996	190.854	1.06362
137	no value	testican-3 precursor. [swissprot;acc:q9bq16]			220.395	234.389	1.0635
	FOXP3	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	Subtracted	High confidence	263.191	231.394	31.797
	RASAL2	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	Divided		350	290	1.2069
	VPS33B	vacuolar protein sorting 33b (hvps33b). [swissprot;acc:q9h267]	Subtracted	Low confidence	203.678	190.88	12.798
138	no value	transgelin 2 (sm22-alpha homolog). [swissprot;acc:p37802]	Divided		218.36	205.4	1.0631
	ARHGEF6	rho guanine nucleotide exchange factor 6 (pak-interacting exchange factor alpha) (alpha-pix) (cool-2). [swissprot;acc:q15052]	Subtracted		219.273	206.507	12.766

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.