MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 51 to 100 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	network_comparison	green
26	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	PANK3	Divided	58	1.31818	44
	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	no value	Subtracted	322	69	253
27	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	GNAQ		267.136	68.941	336.077
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	SLC25A43	Divided	58	1.31818	44
28	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	ATF3		201.949	1.31416	153.671
	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	GNA11	Subtracted	267.136	68.941	336.077
29	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	GNAZ		267.139	68.936	336.075
	uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]	PPP2R2D	Divided	187.458	1.29991	243.678
30	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	GNAT2	Subtracted	267.14	68.935	336.075
	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	no value	Divided	187.457	1.29991	243.678
31	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	GNAT1	Subtracted	267.14	68.935	336.075
	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]	PPP2R2B	Divided	187.458	1.2999	243.677
32	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	GNAI2	Subtracted	267.142	68.932	336.074
	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4]	PPP2R2C	Divided	187.462	1.29985	243.673
33	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	GNAI1	Subtracted	267.144	68.929	336.073
	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	PPP2R1B	Divided	188.688	1.28647	242.742
34	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	GNAI3	Subtracted	267.144	68.929	336.073
	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	PPP2R1A	Divided	189.07	1.28235	242.453
35	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	GNB5	Subtracted	267.636	67.723	335.359
	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	NFYC	Divided	260.532	1.27519	204.309
36	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	NFYA
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	PRKRAP1	Subtracted	320.927	66.493	254.434
37	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	GNB1		266.716	66.449	333.165
	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	PPP1R14A	Divided	322	1.27273	253
38	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	GNB4	Subtracted	266.933	66.348	333.281
	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	MFAP4	Divided	322	1.27273	253
39	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	GNB3	Subtracted	268.565	65.918	334.483
	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	PPP1R14D	Divided	322	1.27273	253
40	deltex 2. [refseq;acc:nm_020892]	DTX2	Subtracted	333.144	65.751	267.393
	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	FCN2	Divided	322	1.27273	253
41	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	DTX1	Subtracted	332.925	65.651	267.274
	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	no value	Divided	322	1.27273	253
42	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	FOS		204.641	1.2714	160.957
	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	PBK	Subtracted	332.874	65.628	267.246
43	jun dimerization protein. [refseq;acc:nm_130469]	no value	Divided	204.641	1.2714	160.957
	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	KHDRBS3	Subtracted	332.874	65.628	267.246
44	fos-related antigen 2. [swissprot;acc:p15408]	FOSL2	Divided	204.641	1.2707	161.046
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	KHDRBS1	Subtracted	332.874	65.628	267.246
45	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	KHDRBS2
	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	FOSB	Divided	204.641	1.27066	161.051
46	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	FOSL1		204.642	1.27053	161.068
	neuralized-like. [refseq;acc:nm_004210]	NEURL	Subtracted	332.326	65.378	266.948
47	gbp protein isoform a. [refseq;acc:nm_017870]	TMEM132A	Divided	325.586	1.26938	256.492
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	TOB2	Subtracted	350	60	290
48	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	GABARAP	Divided	65.4586	1.26868	83.0461
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	TOB1	Subtracted	350	60	290
49	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	ARRB2	Divided	133	1.26667	105
	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	DAB2IP	Subtracted	350	60	290
50	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	ARRB1	Divided	133	1.26667	105
	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	CPEB4	Subtracted	350	60	290

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.