MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	description	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Value Type	Interaction Map	red	green	network_comparison
7	OSBPL7	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	Measured	Low confidence	736.5	2113.5	2.86965
			Squared		128.386	1057.25	8.23493
			Rooted		27.1385	45.9728	1.69401
	SMPD2	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	Measured	High confidence	1153.5	339.5	3.39764
			Squared		314.926	27.2805	11.544
			Rooted		33.9632	18.4255	1.84327
8	HBS1L	hbs1-like. [refseq;acc:nm_006620]	Ranked		215	322	1.49767
	JMJD1C	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	Rooted	Low confidence	31.8641	47.6922	1.49674
	OSBPL7	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	Ranked		318	240	1.325
	PIGF	phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326]	Measured		3278	5058.5	1.54317
			Squared		2543.26	6056.43	2.38136
	TMEM33	db83 protein. [swissprot;acc:p57088]	Measured	High confidence	1153.5	339.5	3.39764
			Squared		314.926	27.2805	11.544
			Rooted		33.9632	18.4255	1.84327
9	MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Ranked	Low confidence	58	44	1.31818
	TMEM132A	gbp protein isoform a. [refseq;acc:nm_017870]	Rooted		31.8923	47.7107	1.49599
	TOB2	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Measured	High confidence	398.5	1281.5	3.21581
			Squared		37.5863	388.696	10.3414
			Rooted		19.9625	35.798	1.79326
	TUSC3	n33 protein. [swissprot;acc:q13454]	Measured	Low confidence	3278	5058.5	1.54317
			Squared		2543.26	6056.43	2.38136
	XAB1	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Ranked	High confidence	212	309	1.45755
10	no value	implantation-associated protein. [refseq;acc:nm_032121]	Measured	Low confidence	3278	5058.5	1.54317
			Squared		2543.26	6056.43	2.38136
	ATPBD1C	protein x 0004. [refseq;acc:nm_016301]	Ranked	High confidence	212	309	1.45755
	JMJD1A	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	Rooted	Low confidence	31.9296	47.7352	1.49501
	SLC25A43	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Ranked		58	44	1.31818
	TOB1	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Measured	High confidence	398.5	1281.5	3.21581
			Squared		37.5863	388.696	10.3414
			Rooted		19.9625	35.798	1.79326
11	BEST1	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	Ranked	Low confidence	37.318	28.4944	1.30966
	DAB2IP	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Measured	High confidence	398.5	1281.5	3.21581
			Squared		37.5863	388.696	10.3414
			Rooted		19.9625	35.798	1.79326
	JMJD1C	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	Measured	Low confidence	1917.64	2950.5	1.53861
	MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Squared		106226	192141	1.80879
	PRSS3	trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]	Rooted		32.2231	47.928	1.48738
	RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]	Ranked	High confidence	337	232	1.45259
12	BEST4	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]		Low confidence	37.3475	28.5242	1.30933
	CPEB4	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	Measured	High confidence	398.5	1281.5	3.21581
			Squared		37.5863	388.696	10.3414
			Rooted		19.9625	35.798	1.79326
	PRSS1	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]		Low confidence	32.2966	47.9763	1.48549
	RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Ranked	High confidence	337	232	1.45259
	SLC25A43	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Squared	Low confidence	106226	192141	1.80879
	TMEM132A	gbp protein isoform a. [refseq;acc:nm_017870]	Measured		1921.96	2954.24	1.5371
13	no value	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Ranked		37.9984	29.1831	1.30207
	CPD	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Squared		395912	242799	1.63062
	CPEB3	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Measured	High confidence	398.5	1281.5	3.21581
			Squared		37.5863	388.696	10.3414

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.