MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	Interaction Map	red	green	network_comparison
13	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	UFC1	Divided	High confidence	288.754	212.554	1.3585
			Subtracted	Low confidence	255.046	202.362	52.684
14	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	CYP27B1			286.396	238.476	47.92
	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	ATG4A	Divided	High confidence	56.6768	75.3531	1.32952
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	GNG4	Subtracted		266.863	336.191	69.328
	vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682]	BEST2	Divided	Low confidence	37.9984	29.1831	1.30207
15	cytochrome p450 27, mitochondrial precursor (ec 1.14.-.-) (cytochrome p-450c27/25) (sterol 26-hydroxylase) (sterol 27-hydroxylase) (vitamin d(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase). [swissprot;acc:q02318]	CYP27A1	Subtracted		286.347	238.454	47.893
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	GNG3		High confidence	266.863	336.19	69.327
	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	MAP1LC3B	Divided		56.7244	75.3948	1.32914
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	UFC1		Low confidence	255.046	202.362	1.26035
16	cytochrome p450 24a1, mitochondrial precursor (ec 1.14.-.-) (p450- cc24) (vitamin d(3) 24-hydroxylase) (1,25-dihydroxyvitamin d(3) 24- hydroxylase) (24-ohase). [swissprot;acc:q07973]	CYP24A1	Subtracted		284.798	237.743	47.055
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	GNG8		High confidence	266.864	336.184	69.32
	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	MAP1LC3A	Divided		56.7252	75.3954	1.32913
	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	JMJD1C		Low confidence	305.472	247.246	1.2355
17	bcl2-related ovarian killer. [refseq;acc:nm_032515]	BOK	Subtracted		265.638	223.235	42.403
	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	ATG4B	Divided	High confidence	56.7841	75.447	1.32866
	gbp protein isoform a. [refseq;acc:nm_017870]	TMEM132A		Low confidence	305.399	247.213	1.23537
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	GNG5	Subtracted	High confidence	266.864	336.182	69.318
18	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	GBE1	Divided		185.678	245.247	1.32082
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	GNG10	Subtracted		266.865	336.181	69.316
	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	JMJD1A	Divided	Low confidence	305.303	247.169	1.2352
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	PRKRAP1	Subtracted		273.188	232.49	40.698
19	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	PYGB	Divided	High confidence	185.678	245.247	1.32082
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	no value	Subtracted		266.865	336.178	69.313
	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]	HINT1		Low confidence	188.298	228.509	40.211
	trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]	PRSS3	Divided		304.548	246.824	1.23387
20	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	PYGL		High confidence	185.678	245.247	1.32082
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	GNG11	Subtracted		266.868	336.159	69.291
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	TOB2		Low confidence	297.273	258.59	38.683
	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]	PRSS1	Divided		304.359	246.737	1.23354
21	gbp protein isoform a. [refseq;acc:nm_017870]	TMEM132A	Subtracted	High confidence	325.586	256.492	69.094
	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	MYO15A	Divided		185.678	245.247	1.32082
	phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326]	PIGF		Low confidence	198	163	1.21472
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	TOB1	Subtracted		296.837	258.33	38.507
22	dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985]	MAP2K4			210.241	246.125	35.884
	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	PYGM	Divided	High confidence	185.678	245.247	1.32082
	n33 protein. [swissprot;acc:q13454]	TUSC3		Low confidence	198	163	1.21472
	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	PPP1R14A	Subtracted	High confidence	322	253	69
23	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	MRPS17	Divided		58	44	1.31818
	glucosamine-6-phosphate isomerase. [refseq;acc:nm_138335]	GNPDA2	Subtracted	Low confidence	247.202	282.937	35.735
	implantation-associated protein. [refseq;acc:nm_032121]	no value	Divided		198	163	1.21472
	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	MFAP4	Subtracted	High confidence	322	253	69
24	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	GNPDA1		Low confidence	247.202	282.937	35.735
	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]	HINT1	Divided		188.298	228.509	1.21355
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	PANK1		High confidence	58	44	1.31818
	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	PPP1R14D	Subtracted		322	253	69
25	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	CYP27B1	Divided	Low confidence	286.396	238.476	1.20094
	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	FCN2	Subtracted	High confidence	322	253	69
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	PANK2	Divided		58	44	1.31818
	phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326]	PIGF	Subtracted	Low confidence	198	163	35

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.