MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	Value Type	red	green	network_comparison
7	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	no value	Subtracted	Squared	310840	442993	132153
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	PANK2		Rooted	145.551	168.796	23.245
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	UFC1		Ranked	288.754	212.554	76.2
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	SMPD2	Divided	Measured	1153.5	339.5	3.39764
				Squared	314.926	27.2805	11.544
				Rooted	33.9632	18.4255	1.84327
8	db83 protein. [swissprot;acc:p57088]	TMEM33		Measured	1153.5	339.5	3.39764
				Squared	314.926	27.2805	11.544
				Rooted	33.9632	18.4255	1.84327
	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	DNASE2B	Subtracted	Squared	250303	354894	104591
	hbs1-like. [refseq;acc:nm_006620]	HBS1L	Divided	Ranked	215	322	1.49767
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	JPH3	Subtracted		288	362	74
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	PANK1		Measured	21185	28492	7307
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	PANK3		Rooted	145.551	168.796	23.245
9	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	JPH2		Ranked	288	362	74
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	SLC25A43		Rooted	145.551	168.796	23.245
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	PANK2		Measured	21185	28492	7307
	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	PPP1R7		Squared	256169	162517	93652
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	TOB2	Divided	Measured	398.5	1281.5	3.21581
				Squared	37.5863	388.696	10.3414
				Rooted	19.9625	35.798	1.79326
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	XAB1		Ranked	212	309	1.45755
10	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	MAGED4	Subtracted	Squared	219048	129762	89286
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	PANK3		Measured	21185	28492	7307
	protein x 0004. [refseq;acc:nm_016301]	ATPBD1C	Divided	Ranked	212	309	1.45755
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	SMPD2	Subtracted		288	362	74
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	TOB1	Divided	Measured	398.5	1281.5	3.21581
				Squared	37.5863	388.696	10.3414
				Rooted	19.9625	35.798	1.79326
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	XAB1	Subtracted		51.6817	29.5127	22.169
11	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	DAB2IP	Divided	Measured	398.5	1281.5	3.21581
				Squared	37.5863	388.696	10.3414
				Rooted	19.9625	35.798	1.79326
	db83 protein. [swissprot;acc:p57088]	TMEM33	Subtracted	Ranked	288	362	74
	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	MAGEE2		Squared	219048	129762	89286
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	SLC25A43		Measured	21185	28492	7307
	protein x 0004. [refseq;acc:nm_016301]	ATPBD1C		Rooted	51.6817	29.5127	22.169
	rad50-interacting protein 1. [refseq;acc:nm_021930]	RINT1	Divided	Ranked	337	232	1.45259
12	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	ARRB2	Subtracted	Rooted	80.4705	101.526	21.0555
	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	CPEB4	Divided	Measured	398.5	1281.5	3.21581
				Squared	37.5863	388.696	10.3414
				Rooted	19.9625	35.798	1.79326
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	no value	Subtracted	Ranked	266.856	336.233	69.377
	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]			Squared	219048	129762	89286
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]			Measured	34190.9	40795.8	6604.9
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	RHOBTB2	Divided	Ranked	337	232	1.45259
13	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	ARRB1	Subtracted	Rooted	80.4705	101.526	21.0555
	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	CPEB3	Divided	Measured	398.5	1281.5	3.21581
				Squared	37.5863	388.696	10.3414
				Rooted	19.9625	35.798	1.79326

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.