MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Network Comparison Type	Rank	description	Gene	Value Type	Hugo	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 482 to 531 of 16578 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
241	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	HOXB4	Low confidence	162.755	155.476	1.04682
242	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	HOXC5
	j domain containing protein 1. [swissprot;acc:q9ukb3]	DNAJC12	High confidence	227.357	254.15	1.11785
243	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	no value	Low confidence	162.755	155.476	1.04682
	sorting nexin 13 (rgs domain- and phox domain-containing protein) (rgs-px1). [swissprot;acc:q9y5w8]	SNX13	High confidence	227.357	254.15	1.11785
244	ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5]	GSTO2
	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	HOXD4	Low confidence	162.755	155.476	1.04682
245	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	HOXB5
	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	SNRPD3	High confidence	226.109	202.333	1.11751
246	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	EIF4G3		237.312	212.363	1.11748
	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	HOXA5	Low confidence	162.755	155.476	1.04682
247	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	no value
	rna-binding protein. [refseq;acc:nm_019027]		High confidence	237.302	212.41	1.11719
248	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]
	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	HSD17B14	Low confidence	162.755	155.476	1.04682
249	dual oxidase 1 precursor; nadph thyroid oxidase 1; flavoprotein nadph oxidase; nicotinamide adenine dinucleotide phosphate oxidase. [refseq;acc:nm_017434]	DUOX1		210.487	201.076	1.0468
	ns1-associated protein 1. [refseq;acc:nm_006372]	SYNCRIP	High confidence	237.302	212.41	1.11719
250	diacylglycerol o-acyltransferase 1 (ec 2.3.1.20) (diglyceride acyltransferase) (acat related gene product 1). [swissprot;acc:o75907]	DGAT1	Low confidence	210.443	201.051	1.04671
	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	HNRNPR	High confidence	237.302	212.41	1.11719
251	nadph oxidase, ef hand calcium-binding domain 5. [refseq;acc:nm_024505]	NOX5	Low confidence	210.415	201.035	1.04666
	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	SLC15A1	High confidence	186.172	166.661	1.11707
252	cytochrome b-245 heavy chain (p22 phagocyte b-cytochrome) (neutrophil cytochrome b, 91 kda polypeptide) (cgd91-phox) (gp91-phox) (heme binding membrane glycoprotein gp91phox) (cytochrome b(558) beta chain) (superoxide-generating nadph oxidase heavy chain subunit). [swissprot;acc:p04839]	CYBB	Low confidence	210.414	201.035	1.04665
	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	EIF4G1	High confidence	237.292	212.457	1.11689
253	mad protein (max dimerizer). [swissprot;acc:q05195]	MXD1		228	204.333	1.11583
	nadph oxidase 4. [refseq;acc:nm_016931]	NOX4	Low confidence	210.413	201.035	1.04665
254	nadph oxidase 3; nadph oxidase catalytic subunit-like 3. [refseq;acc:nm_015718]	NOX3		210.414
	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	STT3B	High confidence	200.691	179.88	1.11569
255	nadph oxidase homolog 1 (nox-1) (noh-1) (nadh/nadph mitogenic oxidase subunit p65-mox) (mitogenic oxidase 1) (mox1). [swissprot;acc:q9y5s8]	NOX1	Low confidence	210.413	201.035	1.04665
	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	STT3A	High confidence	200.691	179.88	1.11569
256	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	MXI1		227.999	204.357
	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	STT3A	Low confidence	199.376	190.521	1.04648
257	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	DDOST	High confidence	200.691	179.88	1.11569
	tropomyosin alpha 3 chain (tropomyosin 3) (tropomyosin gamma). [swissprot;acc:p06753]	TPM3	Low confidence	201.316	192.404	1.04632
258	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	MXD4	High confidence	227.999	204.366	1.11564
	tropomyosin 1 alpha chain (alpha-tropomyosin). [swissprot;acc:p09493]	TPM1	Low confidence	201.304	192.427	1.04613
259	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	RAB24	High confidence	227.999	204.37	1.11562
	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	PDSS1	Low confidence	211.794	202.482	1.04599
260	ankyrin repeat domain protein 7 (testis-specific protein tsa806). [swissprot;acc:q92527]	ANKRD7		216.855	207.34	1.04589
	c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]	HS3ST6	High confidence	219.421	196.978	1.11394
261	ba526d8.2 (novel protein similar to kiaa1074). [sptrembl;acc:q9h560]	ANKRD19	Low confidence	216.845	207.333	1.04588
	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	HS3ST3A1	High confidence	219.421	196.978	1.11394
262	breast cancer antigen ny-br-1. [refseq;acc:nm_052997]	ANKRD30A	Low confidence	216.842	207.332	1.04587
	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]	HS3ST3B1	High confidence	219.421	196.978	1.11394
263	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	HS3ST2
	sodium/hydrogen exchanger 6 (na(+)/h(+) exchanger 6) (nhe-6). [swissprot;acc:q92581]	no value	Low confidence	216.546	207.063	1.0458
264	mrna decapping enzyme; histidine triad protein member 5; heat shock-like protein 1. [refseq;acc:nm_014026]	DCPS	High confidence	219.421	196.978	1.11394
	senescence downregulated leo1-like. [refseq;acc:nm_138792]	LEO1	Low confidence	216.546	207.063	1.0458
265	solute carrier family 9, member 7; nonselective sodium potassium/proton exchanger; sodium/hydrogen exchanger 7. [refseq;acc:nm_032591]	SLC9A7
	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	SF3B1	High confidence	225.217	202.459	1.11241
266	calcineurin b subunit isoform 1 (protein phosphatase 2b regulatory subunit 1) (protein phosphatase 3 regulatory subunit b alpha isoform 1). [swissprot;acc:p06705]	WDR92	Low confidence	214.887	205.509	1.04563

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.