MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	network_comparison	Filtered	red	green

Results: HTML CSV LaTeX

Showing element 482 to 515 of 515 in total

Network Comparison Type  : Subtracted
Value Type  : Ranked
Interaction Map  : Low confidence
network_comparison  : 0
Filtered  : 1
red  : 0
green  : 0

Rank	Hugo	description
5027	COLEC12	collectin sub-family member 12 isoform i; scavenger receptor with c-type lectin; collectin placenta 1; scavenger receptor class a, member 4. [refseq;acc:nm_130386]
5028	CLEC4F	likely ortholog of mouse c-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13; c-type lectin 13; likely ortholog of rat kupffer cell c-type lectin receptor. [refseq;acc:nm_173535]
5029	GGTLA4	gamma-glutamyltransferase-like activity 4; gamma-glutamyltranspeptidase-like. [refseq;acc:nm_080920]
5030	CBWD1	cobw-like protein. [refseq;acc:nm_018491]
5031	TIGD7	tigger transposable element derived 7; jerky (mouse) homolog-like. [refseq;acc:nm_033208]
5032	SRP14	signal recognition particle 14 kda protein (srp14) (18 kda alu rna binding protein). [swissprot;acc:p37108]
5033	RAP1GDS1	rap1 gtpase-gdp dissociation stimulator 1 (smg p21 stimulatory gdp/gtp exchange protein) (smg gds protein) (exchange factor smggds). [swissprot;acc:p52306]
5034	SLCO5A1	solute carrier family 21 member 15 (organic anion transporter polypeptide-related protein 4) (oatp-rp4) (oatprp4). [swissprot;acc:q9h2y9]
5035	LPIN1	lipin 1. [swissprot;acc:q14693]
5036	LPIN3	lipin 3 (lipin 3-like) (fragments). [swissprot;acc:q9bqk8]
5037	PXDN	myeloblast kiaa0230 (fragment). [sptrembl;acc:q92626]
5038	LRRC6	testis specific leucine rich repeat protein. [refseq;acc:nm_012472]
5039	CENPB	major centromere autoantigen b (centromere protein b) (cenp-b). [swissprot;acc:p07199]
5040	LRRFIP1	leucine rich repeat (in flii) interacting protein 1. [refseq;acc:nm_004735]
5041	NAGK	n-acetylglucosamine kinase (ec 2.7.1.59) (glcnac kinase). [swissprot;acc:q9uj70]
5042	TTR	transthyretin precursor (prealbumin) (tbpa) (ttr) (attr). [swissprot;acc:p02766]
5043	no value	late endosomal/lysosomal mp1 interacting protein (p14) (hspc003). [swissprot;acc:q9y2q5]
5044	CD207	langerhans cell specific c-type lectin. [refseq;acc:nm_015717]
5045	CYB561D2	putative tumor suppressor 101f6. [refseq;acc:nm_007022]
5046	HGD	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]
5047	ZNF346	double-stranded rna-binding zinc finger protein jaz. [refseq;acc:nm_012279]
5048	MAP2K1IP1	mitogen-activated protein kinase kinase 1 interacting protein 1 (mek binding partner 1) (mp1) (pro2783). [swissprot;acc:q9uha4]
5050	LPIN2	lipin 2. [swissprot;acc:q92539]
5051	SAMHD1	sam domain and hd domain-containing protein 1 (dendritic cell-derived ifng-induced protein) (dcip) (monocyte protein 5) (mop-5). [swissprot;acc:q9y3z3]
5052	TTLL1	tubulin tyrosine ligase-like protein 1. [swissprot;acc:o95922]
5053	GGTL4	gamma-glutamyltransferase. [sptrembl;acc:q14390]
5054	GGT1	gamma-glutamyltranspeptidase 1 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 1) (cd224 antigen). [swissprot;acc:p19440]
5055	GGTLA1	gamma-glutamyltranspeptidase 5 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 5) (ggt-rel). [swissprot;acc:p36269]
5056	DERL3	putative nadh oxidoreductase complex i subunit homolog. [sptrembl;acc:q96q80]
5057	LRRFIP2	leucine rich repeat (in flii) interacting protein 2. [refseq;acc:nm_006309]
5058	DERL2	carcinoma related gene. [refseq;acc:nm_016041]
5059	CBFB	core-binding factor, beta subunit (cbf-beta) (polyomavirus enhancer binding protein 2 beta subunit) (pebp2-beta) (pea2-beta) (sl3-3 enhancer factor 1 beta subunit) (sl3/akv core-binding factor beta subunit). [swissprot;acc:q13951]
5060	HERPUD1	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (methyl methanesulfonate (mmf)-inducible fragment protein 1). [swissprot;acc:q15011]
5061	RUNX3	runt-related transcription factor 3 (core-binding factor, alpha 3 subunit) (cbf-alpha 3) (acute myeloid leukemia 2 protein) (oncogene aml-2) (polyomavirus enhancer binding protein 2 alpha c subunit) (pebp2-alpha c) (pea2-alpha c) (sl3-3 enhancer factor 1 alpha c subunit) (sl3/akv core-binding factor alpha c subunit). [swissprot;acc:q13761]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.