MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 482 to 531 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	Value Type	description	Interaction Map	red	network_comparison	green
61	GNG5	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	High confidence	266.864	1.25975	336.182
	HOXB5	Measured	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Low confidence	15464.1	1.13635	17572.7
	KCNIP1	Rooted	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	High confidence	43.4291	1.36932	31.7159
	NDN	Squared	necdin. [swissprot;acc:q99608]		219048	1.68808	129762
	PSCD3		cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Low confidence	92920.4	1.29422	71796.4
	PYGB	Measured	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	High confidence	4489.19	1.6231	2765.82
	SMYD2	Rooted	set and mynd domain containing 2; hskm-b protein; zinc finger, mynd domain containing 14. [refseq;acc:nm_020197]	Low confidence	59.2532	1.11478	66.0541
62	FOSL1	Ranked	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]		202.79	1.10804	183.017
	GNG10		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	High confidence	266.865	1.25974	336.181
	HOXA5	Measured	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Low confidence	15464.1	1.13635	17572.7
	KCNIP4	Rooted	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	High confidence	43.4519	1.36847	31.7522
	MAGED1	Squared	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]		219048	1.68808	129762
	PSCD4		cytohesin 4. [swissprot;acc:q9uia0]	Low confidence	92262.9	1.29219	71400.2
	PYGL	Measured	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	High confidence	4489.19	1.6231	2765.82
	SMYD1	Rooted	set and mynd domain containing protein 1. [sptrembl;acc:q8nb12]	Low confidence	59.2532	1.11478	66.0541
63	no value	Measured	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]		15464.1	1.13635	17572.7
		Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	High confidence	266.865	1.25973	336.178
	C1GALT1	Squared	core1 udp-galactose:n-acetylgalactosamine-alpha-r beta 1,3-galac. [refseq;acc:nm_020156]	Low confidence	73677.6	1.28138	57498.7
	KCNIP2	Rooted	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	High confidence	43.4554	1.36835	31.7576
	MAGEF1	Squared	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]		219048	1.68808	129762
	MYO15A	Measured	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]		4489.19	1.6231	2765.82
	RBM7	Ranked	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	Low confidence	265.688	1.10749	239.902
	TBX19	Rooted	t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806]		61.4851	1.10801	68.1264
64	GBE1		1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	High confidence	63.8686	1.35128	47.2654
	GNG11	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]		266.868	1.25965	336.159
	HSD17B14	Measured	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	Low confidence	15464.1	1.13635	17572.7
	JUND	Ranked	transcription factor jun-d. [swissprot;acc:p17535]		202.709	1.10552	183.361
	MAGEB6B	Squared	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	High confidence	219048	1.68808	129762
	NCDN		neurochondrin. [refseq;acc:nm_014284]	Low confidence	73677.6	1.28138	57498.7
	PYGM	Measured	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	High confidence	4489.19	1.6231	2765.82
	RAB11FIP4	Rooted	rab11-family interacting protein 4. [refseq;acc:nm_032932]	Low confidence	73.6221	1.10693	81.4944
65	no value	Squared	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	High confidence	219048	1.68808	129762
	GNAQ	Ranked	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]		267.136	1.25807	336.077
	JUNB		transcription factor jun-b. [swissprot;acc:p17275]	Low confidence	202.728	1.10546	183.388
	NEURL	Measured	neuralized-like. [refseq;acc:nm_004210]	High confidence	1657.68	1.6229	2690.25
	PYGB	Rooted	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]		63.8686	1.35128	47.2654
	RAB11FIP3		eferin. [swissprot;acc:o75154]	Low confidence	73.6221	1.10693	81.4944
	SEPT6	Measured	septin 6. [swissprot;acc:q14141]		13005.8	1.13593	14773.7
	SEPT8	Squared	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]		75490.8	1.26497	95493.3
66	DAB2IP	Rooted	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]		55.8923	1.10573	61.8016
	GNA11	Ranked	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	High confidence	267.136	1.25807	336.077
	MAGEA9	Squared	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]		219048	1.68808	129762
	MTUS1	Ranked	mitochondrial tumor suppressor gene 1; transcription factor mtsg1; at2 receptor-interacting protein 1; erythroid differentiation-related gene. [refseq;acc:nm_020749]	Low confidence	221.902	1.10518	200.783
	NDUFA12	Measured	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	High confidence	1991.03	1.61795	3221.38
	PYGL	Rooted	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]		63.8686	1.35128	47.2654
	SEPT10	Squared	septin 10 isoform 1. [refseq;acc:nm_144710]	Low confidence	74803.9	1.26038	94281
	SON	Measured	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]		4900.7	1.13368	5555.81
67	ARRB2		beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	High confidence	6475.5	1.59177	10307.5
	GNAT2	Ranked	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]		267.14	1.25805	336.075
	MAGEA8	Squared	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]		219048	1.68808	129762

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.