MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Value Type	Hugo	description	Interaction Map	network_comparison	Filtered	red	green

Results: HTML CSV LaTeX

Showing element 467 to 516 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Value Type	Hugo	description	Interaction Map	network_comparison	red	green
59	Ranked	GNG3	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	High confidence	1.25978	266.863	336.19
		NDUFA12	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Low confidence	1.10875	233.134	210.267
	Squared	no value	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	High confidence	1.68808	219048	129762
			mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Low confidence	1.29425	92930	71802.1
	Rooted		atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]		1.11788	75.6323	67.6572
		NDUFA12	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	High confidence	1.40262	37.2205	52.2064
60	Measured	GBE1	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]		1.6231	4489.19	2765.82
		HOXD4	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	Low confidence	1.13635	15464.1	17572.7
	Ranked	FOSL2	fos-related antigen 2. [swissprot;acc:p15408]		1.10839	202.793	182.961
		GNG8	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	High confidence	1.25976	266.864	336.184
	Squared	MAGEA6	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]		1.68808	219048	129762
		PSCD2	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Low confidence	1.29425	92930.5	71802.4
	Rooted	no value	cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]		1.11478	59.2532	66.0541
		SON	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	High confidence	1.39806	35.6294	49.8119
61	Measured	HOXB5	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Low confidence	1.13635	15464.1	17572.7
		PYGB	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	High confidence	1.6231	4489.19	2765.82
	Ranked	FOSB	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Low confidence	1.10831	202.792	182.974
		GNG5	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	High confidence	1.25975	266.864	336.182
	Squared	NDN	necdin. [swissprot;acc:q99608]		1.68808	219048	129762
		PSCD3	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Low confidence	1.29422	92920.4	71796.4
	Rooted	KCNIP1	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	High confidence	1.36932	43.4291	31.7159
		SMYD2	set and mynd domain containing 2; hskm-b protein; zinc finger, mynd domain containing 14. [refseq;acc:nm_020197]	Low confidence	1.11478	59.2532	66.0541
62	Measured	HOXA5	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]		1.13635	15464.1	17572.7
		PYGL	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	High confidence	1.6231	4489.19	2765.82
	Ranked	FOSL1	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	Low confidence	1.10804	202.79	183.017
		GNG10	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	High confidence	1.25974	266.865	336.181
	Squared	MAGED1	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]		1.68808	219048	129762
		PSCD4	cytohesin 4. [swissprot;acc:q9uia0]	Low confidence	1.29219	92262.9	71400.2
	Rooted	KCNIP4	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	High confidence	1.36847	43.4519	31.7522
		SMYD1	set and mynd domain containing protein 1. [sptrembl;acc:q8nb12]	Low confidence	1.11478	59.2532	66.0541
63	Measured	no value	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]		1.13635	15464.1	17572.7
		MYO15A	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	High confidence	1.6231	4489.19	2765.82
	Ranked	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		1.25973	266.865	336.178
		RBM7	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	Low confidence	1.10749	265.688	239.902
	Squared	C1GALT1	core1 udp-galactose:n-acetylgalactosamine-alpha-r beta 1,3-galac. [refseq;acc:nm_020156]		1.28138	73677.6	57498.7
		MAGEF1	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	High confidence	1.68808	219048	129762
	Rooted	KCNIP2	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]		1.36835	43.4554	31.7576
		TBX19	t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806]	Low confidence	1.10801	61.4851	68.1264
64	Measured	HSD17B14	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]		1.13635	15464.1	17572.7
		PYGM	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	High confidence	1.6231	4489.19	2765.82
	Ranked	GNG11	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]		1.25965	266.868	336.159
		JUND	transcription factor jun-d. [swissprot;acc:p17535]	Low confidence	1.10552	202.709	183.361
	Squared	MAGEB6B	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	High confidence	1.68808	219048	129762
		NCDN	neurochondrin. [refseq;acc:nm_014284]	Low confidence	1.28138	73677.6	57498.7
	Rooted	GBE1	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	High confidence	1.35128	63.8686	47.2654
		RAB11FIP4	rab11-family interacting protein 4. [refseq;acc:nm_032932]	Low confidence	1.10693	73.6221	81.4944
65	Measured	NEURL	neuralized-like. [refseq;acc:nm_004210]	High confidence	1.6229	1657.68	2690.25
		SEPT6	septin 6. [swissprot;acc:q14141]	Low confidence	1.13593	13005.8	14773.7
	Ranked	GNAQ	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	High confidence	1.25807	267.136	336.077
		JUNB	transcription factor jun-b. [swissprot;acc:p17275]	Low confidence	1.10546	202.728	183.388

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.