MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

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Showing element 462 to 511 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Value Type	Hugo	red	network_comparison	green
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	Subtracted	1041	Ranked	SRD5A2	220.118	6.433	213.685
		1245	Measured		5885	486.14	6371.14
		2527	Squared		28935	1080.7	30015.7
3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	Divided	897	Ranked	PDPK1	272.878	1.03882	283.472
		2394	Rooted		43.4014	1.01582	42.7253
		2547	Measured		3370.46	1.02187	3444.18
		2650	Squared		16658.1	1.02847	16197
	Subtracted	739	Ranked		272.878	10.594	283.472
		2500	Rooted		43.4014	0.6761	42.7253
		2627	Measured		3370.46	73.72	3444.18
		2675	Squared		16658.1	461.1	16197
38 kda fk-506 binding protein homolog (fkbpr38) (fk506-binding protein 8). [swissprot;acc:q14318]	Divided	1826	Rooted	FKBP8	67.8897	1.03048	69.9589
		2261	Measured		6486.84	1.04615	6786.23
		2358	Ranked		198.181	1.00423	197.346
		2710	Squared		27920.7	1.01489	28336.5
	Subtracted	1714	Rooted		67.8897	2.0692	69.9589
		2133	Measured		6486.84	299.39	6786.23
		2385	Ranked		198.181	0.835	197.346
		2679	Squared		27920.7	415.8	28336.5
4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]	Divided	696		no value	22778.5	1.17186	26693.1
		1469	Measured		5473.09	1.07571	5887.45
		1745	Ranked		219.423	1.01272	222.215
		2352	Rooted		60.9091	1.01785	61.9962
	Subtracted	823	Squared		22778.5	3914.6	26693.1
		1658	Measured		5473.09	414.36	5887.45
		1720	Ranked		219.423	2.792	222.215
		2363	Rooted		60.9091	1.0871	61.9962
40s ribosomal protein s11. [swissprot;acc:p04643]	Divided	278	Ranked	RPS11	241.399	1.10642	267.088
		335	Rooted		50.4705	1.10841	45.5342
		1873	Measured		3618.46	1.0636	3402.09
		2016	Squared		12389	1.09081	13514
	Subtracted	199	Ranked		241.399	25.689	267.088
		585	Rooted		50.4705	4.9363	45.5342
		2360	Measured		3618.46	216.37	3402.09
		2517	Squared		12389	1125	13514
40s ribosomal protein s13. [swissprot;acc:q02546]	Divided	776		RPS13	21976	1.16527	25607.9
		1498	Measured		5414.98	1.07456	5818.7
		1722	Ranked		220.899	1.01319	223.813
		2348	Rooted		60.5137	1.01798	61.6019
	Subtracted	936	Squared		21976	3631.9	25607.9
		1677	Measured		5414.98	403.72	5818.7
		1695	Ranked		220.899	2.914	223.813
		2361	Rooted		60.5137	1.0882	61.6019
40s ribosomal protein s14 (pro2640). [swissprot;acc:p06366]	Divided	386	Ranked	RPS14	242.238	1.09029	264.11
		530	Rooted		50.6537	1.08603	46.6413
		1823	Squared		13145.4	1.09727	14424.1
		2436	Measured		3708.67	1.03465	3584.47
	Subtracted	323	Ranked		242.238	21.872	264.11
		824	Rooted		50.6537	4.0124	46.6413
		2418	Squared		13145.4	1278.7	14424.1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.