MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 458 to 507 of 515 in total

Value Type  : Ranked
Network Comparison Type  : Subtracted
Filtered  : 1
red  : 0
green  : 0
network_comparison  : 0

Rank	Hugo	description	Interaction Map
3213	MDH1	malate dehydrogenase, cytoplasmic (ec 1.1.1.37). [swissprot;acc:p40925]	High confidence
3214	NUB1	bs4 protein (ny-ren-18 antigen). [swissprot;acc:q9y5a7]
3215	MBTPS2	membrane-bound transcription factor site 2 protease (ec 3.4.24.-) (site-2 protease) (sterol-regulatory element-binding proteins intramembrane protease). [swissprot;acc:o43462]
3216	ERCC1	dna excision repair protein ercc-1. [swissprot;acc:p07992]
3217	SCMH1	sex comb on midleg homolog 1. [refseq;acc:nm_012236]
3218	MLXIPL	williams-beuren syndrome chromosome region 14 protein (ws basic-helix- loop-helix leucine zipper protein) (ws-bhlh) (mlx interactor). [swissprot;acc:q9np71]
3219	VTA1	protein c6orf55 (dopamine responsive protein drg-1) (my012 protein) (hspc228). [swissprot;acc:q9np79]
3220	TFAP2B	transcription factor ap-2 beta (ap2-beta) (activating enhancer-binding protein 2 beta). [swissprot;acc:q92481]
3221	PAFAH1B1	platelet-activating factor acetylhydrolase ib alpha subunit (ec 3.1.1.47) (paf acetylhydrolase 45 kda subunit) (paf-ah 45 kda subunit) (paf-ah alpha) (pafah alpha) (lissencephaly-1 protein) (lis- 1). [swissprot;acc:p43034]
3222	ALDH3B1	aldehyde dehydrogenase 7 (ec 1.2.1.5). [swissprot;acc:p43353]
3223	RALA	ras-related protein ral-a. [swissprot;acc:p11233]
3224	ITGA3	integrin alpha-3 precursor (galactoprotein b3) (gapb3) (vla-3 alpha chain) (cd49c). [swissprot;acc:p26006]
3225	HSPB6	heat-shock 20 kda like-protein p20. [swissprot;acc:o14558]
3226	no value	ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]
3227	ICA1	69 kda islet cell autoantigen (ica69) (islet cell autoantigen 1) (islet cell autoantigen p69) (icap69). [swissprot;acc:q05084]
3228	SCYL3	ezrin-binding partner pace-1 isoform 1. [refseq;acc:nm_020423]
5019	JRKL	jerky protein homolog like (hhmjg). [swissprot;acc:q9y4a0]	Low confidence
5020	no value	gamma-glutamyltranspeptidase 2 (ec 2.3.2.2) (gamma-glutamyltransferase 2) (fragment). [swissprot;acc:p36268]
5021	HDAC3	histone deacetylase 3 (hd3) (rpd3-2). [swissprot;acc:o15379]
5022	TIGD1	tigger transposable element derived 1; jerky (mouse) homolog-like. [refseq;acc:nm_145702]
5023	SPNS1	spinster-like protein. [sptrembl;acc:q9h2v7]
5024	TK2	thymidine kinase 2, mitochondrial precursor (ec 2.7.1.21) (mt-tk). [swissprot;acc:o00142]
5025	TIGD6	tigger transposable element derived 6. [refseq;acc:nm_030953]
5026	RUNX1	runt-related transcription factor 1 (core-binding factor, alpha 2 subunit) (cbf-alpha 2) (acute myeloid leukemia 1 protein) (oncogene aml-1) (polyomavirus enhancer binding protein 2 alpha b subunit) (pebp2-alpha b) (pea2-alpha b) (sl3-3 enhancer factor 1 alpha b subunit) (sl3/akv core-binding factor alpha b subunit). [swissprot;acc:q01196]
5027	COLEC12	collectin sub-family member 12 isoform i; scavenger receptor with c-type lectin; collectin placenta 1; scavenger receptor class a, member 4. [refseq;acc:nm_130386]
5028	CLEC4F	likely ortholog of mouse c-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13; c-type lectin 13; likely ortholog of rat kupffer cell c-type lectin receptor. [refseq;acc:nm_173535]
5029	GGTLA4	gamma-glutamyltransferase-like activity 4; gamma-glutamyltranspeptidase-like. [refseq;acc:nm_080920]
5030	CBWD1	cobw-like protein. [refseq;acc:nm_018491]
5031	TIGD7	tigger transposable element derived 7; jerky (mouse) homolog-like. [refseq;acc:nm_033208]
5032	SRP14	signal recognition particle 14 kda protein (srp14) (18 kda alu rna binding protein). [swissprot;acc:p37108]
5033	RAP1GDS1	rap1 gtpase-gdp dissociation stimulator 1 (smg p21 stimulatory gdp/gtp exchange protein) (smg gds protein) (exchange factor smggds). [swissprot;acc:p52306]
5034	SLCO5A1	solute carrier family 21 member 15 (organic anion transporter polypeptide-related protein 4) (oatp-rp4) (oatprp4). [swissprot;acc:q9h2y9]
5035	LPIN1	lipin 1. [swissprot;acc:q14693]
5036	LPIN3	lipin 3 (lipin 3-like) (fragments). [swissprot;acc:q9bqk8]
5037	PXDN	myeloblast kiaa0230 (fragment). [sptrembl;acc:q92626]
5038	LRRC6	testis specific leucine rich repeat protein. [refseq;acc:nm_012472]
5039	CENPB	major centromere autoantigen b (centromere protein b) (cenp-b). [swissprot;acc:p07199]
5040	LRRFIP1	leucine rich repeat (in flii) interacting protein 1. [refseq;acc:nm_004735]
5041	NAGK	n-acetylglucosamine kinase (ec 2.7.1.59) (glcnac kinase). [swissprot;acc:q9uj70]
5042	TTR	transthyretin precursor (prealbumin) (tbpa) (ttr) (attr). [swissprot;acc:p02766]
5043	no value	late endosomal/lysosomal mp1 interacting protein (p14) (hspc003). [swissprot;acc:q9y2q5]
5044	CD207	langerhans cell specific c-type lectin. [refseq;acc:nm_015717]
5045	CYB561D2	putative tumor suppressor 101f6. [refseq;acc:nm_007022]
5046	HGD	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]
5047	ZNF346	double-stranded rna-binding zinc finger protein jaz. [refseq;acc:nm_012279]
5048	MAP2K1IP1	mitogen-activated protein kinase kinase 1 interacting protein 1 (mek binding partner 1) (mp1) (pro2783). [swissprot;acc:q9uha4]
5050	LPIN2	lipin 2. [swissprot;acc:q92539]
5051	SAMHD1	sam domain and hd domain-containing protein 1 (dendritic cell-derived ifng-induced protein) (dcip) (monocyte protein 5) (mop-5). [swissprot;acc:q9y3z3]
5052	TTLL1	tubulin tyrosine ligase-like protein 1. [swissprot;acc:o95922]
5053	GGTL4	gamma-glutamyltransferase. [sptrembl;acc:q14390]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.