MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 451 to 500 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
113	PPP2CA	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	Subtracted	High confidence	194.372	234.204	39.832
	SLC11A2	natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281]		Low confidence	224.763	210.566	14.197
114	B9D1	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		High confidence	229.818	267.265	37.447
	DLGAP1	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]	Divided	Low confidence	197.779	211.983	1.07182
	KHDRBS1	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]		High confidence	332.874	267.246	1.24557
	MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Subtracted	Low confidence	58	44	14
115	DLGAP4	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	Divided		197.779	211.983	1.07182
	HAT1	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Subtracted	High confidence	277.546	240.461	37.085
	KHDRBS2	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	Divided		332.874	267.246	1.24557
	SLC25A43	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Subtracted	Low confidence	58	44	14
116	no value	testican-3 precursor. [swissprot;acc:q9bq16]			220.395	234.389	13.994
	GNB3	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	Divided	High confidence	268.565	334.483	1.24545
	HMG20B	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Subtracted		208.52	171.595	36.925
	VPS18	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	Divided	Low confidence	204.161	190.791	1.07008
117	ABRA	striated muscle activator of rho-dependent signaling. [refseq;acc:nm_139166]	Subtracted		225.495	211.529	13.966
	F13A1	coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- glutamine gamma-glutamyltransferase a chain) (transglutaminase a chain). [swissprot;acc:p00488]	Divided		226.395	211.713	1.06935
	HMG20A	high-mobility group 20a. [refseq;acc:nm_018200]	Subtracted	High confidence	208.588	171.778	36.81
	NEURL	neuralized-like. [refseq;acc:nm_004210]	Divided		332.326	266.948	1.24491
118	NDUFA12	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]			284.753	228.934	1.24382
	OSR1	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	Subtracted		274.027	237.79	36.237
	SPOCK1	testican-1 precursor (spock protein). [swissprot;acc:q08629]		Low confidence	220.254	234.111	13.857
	TGM1	protein-glutamine gamma-glutamyltransferase k (ec 2.3.2.13) (transglutaminase k) (tgase k) (tgk) (tg(k)) (transglutaminase 1) (epidermal tgase). [swissprot;acc:p22735]	Divided		226.395	211.713	1.06935
119	ADIPOR2	adiponectin receptor 2. [refseq;acc:nm_024551]	Subtracted	High confidence	281.582	246.371	35.211
	NDUFS4	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	Divided		318.982	259.004	1.23157
	SLC11A1	natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279]		Low confidence	225.666	211.107	1.06897
	SPOCK2	testican-2 precursor. [swissprot;acc:q92563]	Subtracted		220.222	234.047	13.825
120	no value	nanos (fragment). [sptrembl;acc:q8wy41]			203.66	217.479	13.819
	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	Divided		203.016	189.965	1.0687
	KCND2	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]		High confidence	269.278	327.709	1.21699
	TIA1	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	Subtracted		227.199	192.715	34.484
121	CTH	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	Divided		269.254	327.655	1.2169
	DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]		Low confidence	203.007	189.985	1.06854
	TIAL1	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	Subtracted	High confidence	227.202	192.823	34.379
	VPS33A	vacuolar protein sorting 33a (hvps33a). [swissprot;acc:q96ax1]		Low confidence	203.914	190.189	13.725
122	no value	nanos (fragment). [sptrembl;acc:q8wy41]	Divided		203.66	217.479	1.06785
	COPS3	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	Subtracted	High confidence	199.949	234.187	34.238
	KCND3	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	Divided		269.248	327.642	1.21688
	VPS18	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	Subtracted	Low confidence	204.161	190.791	13.37
123	DVL3	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	Divided		202.96	190.094	1.06768
	KCND1	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]		High confidence	269.23	327.601	1.21681
	SNRPD1	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	Subtracted		227.032	193.056	33.976
	STRN	striatin. [swissprot;acc:o43815]		Low confidence	214.085	200.796	13.289
124	DAZAP1	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]			220.268	206.997	13.271
	HMG20B	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Divided	High confidence	208.52	171.595	1.21519
	PSEN2	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Subtracted		285.684	252.234	33.45
	SLC11A2	natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281]	Divided	Low confidence	224.763	210.566	1.06742
125	B9D1	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]			213.243	227.616	1.0674
	HMG20A	high-mobility group 20a. [refseq;acc:nm_018200]		High confidence	208.588	171.778	1.21429
	PROM1	prominin-like protein 1 precursor (antigen ac133) (cd133 antigen). [swissprot;acc:o43490]	Subtracted	Low confidence	220.268	206.997	13.271
	SKP1A	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]		High confidence	285.684	252.234	33.45

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.